Vis enkel innførsel

dc.contributor.authorMoestue, Siver Andreas
dc.contributor.authorGribbestad, Ingrid S
dc.contributor.authorHansen, Rune
dc.date.accessioned2015-09-29T12:21:10Z
dc.date.accessioned2015-10-16T13:43:45Z
dc.date.available2015-09-29T12:21:10Z
dc.date.available2015-10-16T13:43:45Z
dc.date.issued2012
dc.identifier.citationInternational Journal of Molecular Sciences 2012, 13(6):6679-6697nb_NO
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/11250/2356389
dc.description.abstractMolecular targeting of contrast agents for ultrasound imaging is emerging as a new medical imaging modality. It combines advances in ultrasound technology with principles of molecular imaging, thereby allowing non-invasive assessment of biological processes in vivo. Preclinical studies have shown that microbubbles, which provide contrast during ultrasound imaging, can be targeted to specific molecular markers. These microbubbles accumulate in tissue with target (over) expression, thereby significantly increasing the ultrasound signal. This concept offers safe and low-cost imaging with high spatial resolution and sensitivity. It is therefore considered to have great potential in cancer imaging, and early-phase clinical trials are ongoing. In this review, we summarize the current literature on targets that have been successfully imaged in preclinical models using molecularly targeted ultrasound contrast agents. Based on preclinical experience, we discuss the potential clinical utility of targeted microbubbles.nb_NO
dc.language.isoengnb_NO
dc.publisherMDPInb_NO
dc.titleIntravascular Targets for Molecular Contrast-Enhanced Ultrasound Imagingnb_NO
dc.typeJournal articlenb_NO
dc.typePeer revieweden_GB
dc.date.updated2015-09-29T12:21:10Z
dc.source.volume13nb_NO
dc.source.journalInternational Journal of Molecular Sciencesnb_NO
dc.source.issue6nb_NO
dc.identifier.doi10.3390/ijms13066679
dc.identifier.cristin930433
dc.description.localcodeThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.nb_NO


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel