• Klotho and GPLD-1: Predictive Biomarkers for Development of Alzheimer's Disease in Older Adults 

      Zaman, Ali (Master thesis, 2023)
      Bakgrunn: Alzheimers sykdom (AD) er en nevrodegenerativ sykdom og den vanligste formen for demens. I 2023 påvirker demens over 55 millioner mennesker globalt, og det er forventet å øke til 152 millioner innen 2050. Likevel ...
    • Knowledge Across Reference Frames: Cognitive Maps and Image Spaces 

      Bottini, Roberto; Doeller, Christian Fritz Andreas (Peer reviewed; Journal article, 2020)
      In human and non-human animals, conceptual knowledge is partially organized according to low-dimensional geometries that rely on brain structures and computations involved in spatial representations. Recently, two separate ...
    • Lack of sex-specific movement patterns in an alien species at its invasion front - consequences for invasion speed 

      Herfindal, Ivar; Melis, Claudia; Åhlén, Per-Arne; Dahl, Fredrik (Journal article; Peer reviewed, 2016)
      Efficient targeting of actions to reduce the spread of invasive alien species relies on understanding the spatial, temporal, and individual variation of movement, in particular related to dispersal. Such patterns may differ ...
    • Landmark-based spatial navigation across the human lifespan 

      Becu, Marcia Constance Noemi; Sheynikhovich, Denis; Ramanoël, Stephen; Tatur, Guillaume; Ozier-Lafontaine, Anthony; Authié, Colas N.; Sahel, José-Alain; Arleo, Angelo (Journal article; Peer reviewed, 2023)
    • Large-scale two-photon calcium imaging in freely moving mice 

      Zong, Weijian; Obenhaus, Horst-Andreas; Skytøen, Emilie; Eneqvist, Hanna; de Jong, Nienke Laura; Vale, Ruben Duque do; Rodrigues Jorge, Marina; Moser, May-Britt; Moser, Edvard Ingjald (Journal article; Peer reviewed, 2022)
      We developed a miniaturized two-photon microscope (MINI2P) for fast, high-resolution, multiplane calcium imaging of over 1,000 neurons at a time in freely moving mice. With a microscope weight below 3 g and a highly flexible ...
    • Latching dynamics as a basis for short-term recall 

      Ryom, Kwang Il; Boboeva, Vezha; Soldatkina, Oleksandra; Treves, Alessandro (Peer reviewed; Journal article, 2021)
      We discuss simple models for the transient storage in short-term memory of cortical patterns of activity, all based on the notion that their recall exploits the natural tendency of the cortex to hop from state to state—latching ...
    • Learning and representation of hierarchical concepts in hippocampus and prefrontal cortex 

      Theves, Stephanie; Neville, David A.; Fernández, Guillén; Doeller, Christian F. (Peer reviewed; Journal article, 2021)
      A key aspect of conceptual knowledge is that it can be flexibly applied at different levels of abstraction, implying a hierarchical organization. It is yet unclear how this hierarchical structure is acquired and represented ...
    • Learning functional connectivity in the under-sampled regime 

      Bulso, Nicola (Doctoral theses at NTNU;2020:128, Doctoral thesis, 2020)
      Læring funksjonell tilkobling i under-samplet regime Siden de første dagene har nevrovitenskap forsker merket at den elektriske aktiviteten til noen nevroner i hjernen korrelerer med spesifikke trekk i den ekstern verden. ...
    • Learning with unknowns: analyzing biological data in the presence of hidden variables 

      Battistin, Claudia; Dunn, Benjamin Adric; Roudi, Yasser (Journal article, 2017)
      Despite our improved ability to probe biological systems at a higher spatio-temporal resolution, the high dimensionality of the biological systems often prevents sufficient sampling of the state space. Even with large scale ...
    • Life on the edge: Latching dynamics in a Potts neural network 

      Kang, Chol Jun; Naim, Michelangelo; Boboeva, Vezha; Treves, Alessandro (Journal article; Peer reviewed, 2017)
      We study latching dynamics in the adaptive Potts model network, through numerical simulations with randomly and also weakly correlated patterns, and we focus on comparing its slowly and fast adapting regimes. A measure, ...
    • Linking Structural MRI to Behavior and Real-World Emotional Experiences 

      Jain, Avneesh (Master thesis, 2023)
      I kjernen av menneskelig erkjennelse ligger kompleksiteten av assosiasjoner til hjerne-atferd, hvor den ene påvirker den andre gjennom livet. Selv om det er komplisert å feste egenskaper med ett enkelt område av interesse, ...
    • Local projections of layer Vb-to-Va are more prominent in lateral than in medial entorhinal cortex 

      Ohara, Shinya; Blankvoort, Stefan; Nair Raveendran, Rajeevkumar; Nigro, Maximiliano Jose; Nilssen, Eirik Stamland; Kentros, Clifford; Witter, Menno (Peer reviewed; Journal article, 2021)
      The entorhinal cortex, in particular neurons in layer V, allegedly mediate transfer of information from the hippocampus to the neocortex, underlying long-term memory. Recently, this circuit has been shown to comprise a ...
    • Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity 

      Hotz, Adriana L.; Jamali, Ahmed; Rieser, Nicolas N.; Niklaus, Stephanie; Aydin, Ecem; Myren-Svelstad, Sverre; Lalla, Laetitia Noelle Patricia; Jurisch-Yaksi, Nathalie; Yaksi, Emre; Neuhauss, Stephan C.F. (Peer reviewed; Journal article, 2021)
      Astroglial excitatory amino acid transporter 2 (EAAT2, GLT-1, and SLC1A2) regulates the duration and extent of neuronal excitation by removing glutamate from the synaptic cleft. Hence, an impairment in EAAT2 function could ...
    • Lowering levels of reelin in entorhinal cortex layer II-neurons results in lowered levels of intracellular amyloid-β 

      Kobro-Flatmoen, Asgeir; Battistin, Claudia; Raveendran Nair, Rajeevkumar; Bjorkli, Christiana; Skender, Belma; Kentros, Clifford George; Gouras, Gunnar; Witter, Menno Peter (Peer reviewed; Journal article, 2023)
      Projection neurons in the anteriolateral part of entorhinal cortex layer II are the predominant cortical site for hyper-phosphorylation of tau and formation of neurofibrillary tangles in prodromal Alzheimer’s disease. A ...
    • A Machine Learning Approach to Investigate Fronto-Parietal Neural Ensemble Dynamics During Complex 

      Gheorghiu, Medorian; Ciuparu, Andrei; Mimica, Bartul; Whitlock, Jonathan; Mureşan, Raul (Chapter, 2020)
      Brain circuits exhibit very complex dynamics, where individual neurons fire action potentials determining coordinated activity patterns. During behavior, a multitude of brain areas are engaged in planning and execution. A ...
    • Magnetic field compensation coil design for magnetoencephalography 

      Kutschka, Hermann; Doeller, Christian Fritz Andreas; Haueisen, Jens; Maess, Burkhard (Peer reviewed; Journal article, 2021)
      Acknowledgements This project was supported by the Max Planck Society; and the Free State of Thuringia under 2018 IZN 004 cofinanced by the European Union under the European Regional Development Fund (ERDF); CFD’s research ...
    • Magnetic resonance-based eye tracking using deep neural networks 

      Frey, Markus; Nau, Matthias; Doeller, Christian F. (Journal article, 2021)
      Viewing behavior provides a window into many central aspects of human cognition and health, and it is an important variable of interest or confound in many functional magnetic resonance imaging (fMRI) studies. To make eye ...
    • Mapping sequence structure in the human lateral entorhinal cortex 

      Bellmund, Jacob Lukas Sarid; Deuker, Lorena; Doeller, Christian Fritz Andreas (Journal article; Peer reviewed, 2019)
      Remembering event sequences is central to episodic memory and presumably supported by the hippocampal-entorhinal region. We previously demonstrated that the hippocampus maps spatial and temporal distances between events ...
    • Mental search of concepts is supported by egocentric vector representations and restructured grid maps 

      Viganò, Simone; Bayramova, Rena; Döller, Christian Fritz Andreas; Bottini, Roberto (Peer reviewed; Journal article, 2023)
      The human hippocampal-entorhinal system is known to represent both spatial locations and abstract concepts in memory in the form of allocentric cognitive maps. Using fMRI, we show that the human parietal cortex evokes ...
    • Methods for studying the zebrafish brain: Past, present and future 

      Wyatt, Cameron; Bartoszek, Ewelina; Yaksi, Emre (Journal article; Peer reviewed, 2015)
      The zebrafish (Danio rerio) is one of the most promising new model organisms. The increasing popularity of this amazing small vertebrate is evident from the exponentially growing numbers of research articles, funded projects ...