Browsing Institutt for samfunnsmedisin og sykepleie by Journals "PLoS Genetics"
Now showing items 1-10 of 10
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A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium
(Journal article; Peer reviewed, 2011) -
Age-of-onset information helps identify 76 genetic variants associated with allergic disease
(Peer reviewed; Journal article, 2020)Risk factors that contribute to inter-individual differences in the age-of-onset of allergic diseases are poorly understood. The aim of this study was to identify genetic risk variants associated with the age at which ... -
Assortative mating and within-spouse pair comparisons
(Peer reviewed; Journal article, 2021)Spousal comparisons have been proposed as a design that can both reduce confounding and estimate effects of the shared adulthood environment. However, assortative mating, the process by which individuals select phenotypically ... -
Common variants show predicted polygenic effects on height in the tails of the distribution, except in extremely short individuals
(Journal article; Peer reviewed, 2011)Common genetic variants have been shown to explain a fraction of the inherited variation for many common diseases and quantitative traits, including height, a classic polygenic trait. The extent to which common variation ... -
Estimating indirect parental genetic effects on offspring phenotypes using virtual parental genotypes derived from sibling and half sibling pairs
(Peer reviewed; Journal article, 2020)Indirect parental genetic effects may be defined as the influence of parental genotypes on offspring phenotypes over and above that which results from the transmission of genes from parents to their children. However, given ... -
Evaluating indirect genetic effects of siblings using singletons
(Peer reviewed; Journal article, 2022)Estimating effects of parental and sibling genotypes (indirect genetic effects) can provide insight into how the family environment influences phenotypic variation. There is growing molecular genetic evidence for effects ... -
Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults
(Journal article; Peer reviewed, 2017)Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and ... -
Polygenic and socioeconomic risk for high body mass index: 69 years of follow-up across life
(Peer reviewed; Journal article, 2022)Genetic influences on body mass index (BMI) appear to markedly differ across life, yet existing research is equivocal and limited by a paucity of life course data. We thus used a birth cohort study to investigate differences ... -
Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers
(Journal article; Peer reviewed, 2014)We previously used a single nucleotide polymorphism (SNP) in the CHRNA5-A3-B4 gene cluster associated with heaviness of smoking within smokers to confirm the causal effect of smoking in reducing body mass index (BMI) in a ... -
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
(Journal article; Peer reviewed, 2015)Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and ...