• Investigating causal relations between sleep traits and risk of breast cancer in women: Mendelian randomisation study 

      Richmond, Rebecca C.; Anderson, Emma L.; Dashti, Hassan S.; Jones, Samuel E.; Lane, Jacqueline M.; Strand, Linn B; Brumpton, Ben Michael; Rutter, Martin K.; Wood, Andrew R.; Straif, Kurt; Relton, Caroline L.; Munafò, Marcus; Frayling, Timothy M.; Martin, Richard M.; Saxena, Richa; Weedon, Michael N.; Lawlor, Debbie A.; Smith, George Davey (Peer reviewed; Journal article, 2019)
      Objective To examine whether sleep traits have a causal effect on risk of breast cancer. Design Mendelian randomisation study. Setting UK Biobank prospective cohort study and Breast Cancer Association Consortium ...
    • Investigating how the accuracy of teacher expectations of pupil performance relate to socioeconomic and genetic factors 

      Barry, Ciarrah-Jane Shannon; Davies, Neil Martin; Morris, Tim T. (Peer reviewed; Journal article, 2022)
      Teacher expectations of pupil ability can influence educational progression, impacting subsequent streaming and exam level. Systematic discrepancies between teacher expectations of pupil achievement may therefore have a ...
    • Investigating the causal effect of maternal vitamin B12 and folate levels on offspring birthweight 

      Moen, Gunn-Helen; Beaumont, Robin N.; Grarup, Niels; Sommer, Christine; Shields, Beverley M.; Lawlor, Debbie A.; Freathy, Rachel M.; Evans, David M.; Warrington, Nicole Maree (Peer reviewed; Journal article, 2021)
      Background Lower maternal serum vitamin B12 (B12) and folate levels have been associated with lower offspring birthweight, in observational studies. The aim of this study was to investigate whether this relationship is ...
    • Investigating the causal effect of smoking on hay fever and asthma: A Mendelian randomization meta-analysis in the CARTA consortium 

      Skaaby, Tea; Taylor, Amy E; Jacobsen, Rikke K.; Paternoster, Lavinia; Thuesen, Betina H.; Ahluwalia, Tarunveer S.; Larsen, Sofus C.; Zhou, Ang; Wong, Andrew; Gabrielsen, Maiken Elvestad; Bjørngaard, Johan Håkon; Flexeder, Claudia; Männistö, Satu; Hardy, Rebecca; Kuh, Diana; Barry, Sarah J.; Møllehave, Line Tang; Cerqueira, Charlotte; Friedrich, Nele; Bonten, Tobias N.; Noordam, Raymond; Mook-Kanamori, Dennis O.; Taube, Christian; Jessen, Leon E.; McConnachie, Alex; Sattar, Naveed; Upton, Mark N.; McSharry, Charles; Bønnelykke, Klaus; Bisgaard, Hans; Schulz, Holger; Strauch, Konstantin; Meitinger, Thomas; Peters, Annette; Grallert, Harald; Nohr, Ellen A.; Kivimäki, Mika; Kumari, Meena; Völker, Uwe; Nauck, Matthias; Völzke, Henry; Power, Chris; Hyppönen, Elina; Hansen, Torben; Jørgensen, Torben; Pedersen, Oluf; Salomaa, Veikko; Grarup, Niels; Langhammer, Arnulf; Romundstad, Pål Richard; Skorpen, Frank; Kaprio, Jaakko; Munafò, Marcus R.; Linneberg, Allan (Journal article; Peer reviewed, 2017)
      Observational studies on smoking and risk of hay fever and asthma have shown inconsistent results. However, observational studies may be biased by confounding and reverse causation. Mendelian randomization uses genetic ...
    • Investigating the causal interplay between sleep traits and risk of acute myocardial infarction: a Mendelian randomization study 

      Arora, Nikhil; Bhatta, Laxmi; Skarpsno, Eivind Schjelderup; Dalen, Håvard; Åsvold, Bjørn Olav; Brumpton, Ben Michael; Richmond, Rebecca C.; Strand, Linn Beate (Peer reviewed; Journal article, 2023)
      Background Few studies have investigated the joint effects of sleep traits on the risk of acute myocardial infarction (AMI). No previous study has used factorial Mendelian randomization (MR) which may reduce confounding, ...
    • Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium 

      Taylor, Amy E; Fluharty, Meg; Bjørngaard, Johan Håkon; Gabrielsen, Maiken Elvestad; Skorpen, Frank; Marioni, Riccardo R.; Campbell, A.; Engmann, J; Mirza, Saira Saeed; Loukola, A.; Laatikainen, Tiina; Partonen, Timo; Kaakinen, Marika; Ducci, Francesca; Cavadino, Alana; Husemoen, Lise Lotte N; Ahluwalia, Tarunveer Singh; Jacobsen, Rikke Kart; Skaaby, Tea; Ebstrup, Jeanette Frost; Mortensen, Erik Lykke; Minica, Camelia C; Vink, Jacqueline; Willemsen, Gonneke; Marques-Vidal, Pedro; Dale, Caroline E; Amuzu, Antoinette; Lennon, Lucy; Lahti, J; Palotie, Aarno; Räikkönen, K; Wong, Andrew; Paternoster, Lavinia; Wong, Angelita Pui-Yee; Horwood, L John; Murphy, Michael; Johnstone, Elaine; Kennedy, Martin A; Pausova, Zdenka; Paus, Tomas; Ben-Shlomo, Yoav; Nohr, Ellen A; Kuh, Diana; Kivimaki, Mika; Eriksson, Johan G; Morris, Richard W; Casas, Juan Pablo; Preisig, Martin; Boomsma, Dorret I; Linneberg, Allan; Power, Chris; Hypponen, Elina; Veijola, J; Järvelin, Marjo-Riitta; Korhonen, T.; Tiemeier, H; Kumari, Meena; Porteous, David J.; Hayward, Caroline; Romundstad, Pål Richard; Smith, George Davey; Munafo, Marcus R (Journal article; Peer reviewed, 2014)
      Objectives: To investigate whether associations of smoking with depression and anxiety are likely to be causal, using a Mendelian randomisation approach. Design: Mendelian randomisation meta-analyses using a genetic ...
    • Investigating the relationship between non-occupational pesticide exposure and metabolomic biomarkers 

      Palaniswamy, Saranya; Abass, Khaled; Rysä, Jaana; Grimalt, Joan O.; Odland, Jon Øyvind; Rautio, Arja; Järvelin, Marjo-Riitta (Journal article; Peer reviewed, 2023)
      The relationship between pesticide exposures and metabolomics biomarkers is not well understood. We examined the changes in the serum metabolome (early biomarkers) and the metabolic pathways associated with various pesticide ...
    • Involvement of service user representatives on a healthcare organizational level at Norwegian Healthy Life Centres: A qualitative study exploring health professionals' experiences 

      Sagsveen, Espen; Rise, Marit By; Westerlund, Heidi; Grønning, Kjersti; Bratås, Ola (Peer reviewed; Journal article, 2023)
      Background The involvement of service user representatives in planning, delivering, and evaluating health care services is regarded as essential in Healthy Life Centres (HLCs) to ensure high-quality services. However, ...
    • Ipilimumab in a real-world population: A prospective Phase IV trial with long-term follow-up 

      Aamdal, Elin; Jacobsen, Kari Dolven; Straume, Oddbjørn; Kersten, Christian; Herlofsen, Oluf; Karlsen, Jarle; Hussain, Israr; Amundsen, Anita; Dalhaug, Astrid; Nyakas, Marta Sølvi; Schuster, Cornelia; Hagene, Kirsten Thorin; Holmsen, Kjersti; Russnes, Hege Elisabeth Giercksky; Skovlund, Eva; Kaasa, Stein; Aamdal, Steinar; Kyte, Jon A.; Guren, Tormod Kyrre (Peer reviewed; Journal article, 2021)
      Ipilimumab was the first treatment that improved survival in advanced melanoma. Efficacy and toxicity in a real-world setting may differ from clinical trials, due to more liberal eligibility criteria and less intensive ...
    • Is chronic low back pain a risk factor for diabetes? The Nord-Trøndelag Health Study 

      HEUCH, INGRID; Heuch, Ivar; Hagen, Knut; Sørgjerd, Elin Pettersen; Åsvold, Bjørn Olav; Zwart, John-Anker (Journal article; Peer reviewed, 2018)
      Objective The purpose of this study was to examine the risk of diabetes associated with the presence or absence of chronic low back pain, considering both cross-sectional and cohort data. Research design and methods ...
    • Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis 

      Anderson, Emma L.; Richmond, Rebecca C.; Jones, Samuel E.; Hemani, Gibran; Wade, Kaitlin H; Dashti, Hassan S.; Lane, Jaqueline; Wang, Heming; Saxena, Richa; Brumpton, Ben Michael; Korologou-Linden, Roxanna; Nielsen, Jonas Bille; Åsvold, Bjørn Olav; Abecasis, Goncalo; Coulthard, Elizabeth; Kyle, Simon D.; Beaumont, Robin N.; Tyrell, Jessica; Frayling, Timothy M; Munafo, Marcus R; Wood, Andrew R; Ben-Shlomo, Yoav; Howe, Laura D; Lawlor, Deborah A.; Weedon, Michael N; Smith, George Davey (Peer reviewed; Journal article, 2020)
      Background It is established that Alzheimer’s disease (AD) patients experience sleep disruption. However, it remains unknown whether disruption in the quantity, quality or timing of sleep is a risk factor for the onset ...
    • Is empiric proton pump inhibition in patients with symptoms of extraesophageal gastroesophageal reflux justified? 

      Fossmark, Reidar; Ness-Jensen, Eivind; Sørdal, Øystein Finset (Peer reviewed; Journal article, 2023)
      Background The prevalence of gastroesophageal reflux disease (GERD) has had a marked increase in Western countries with a paralleling interest in extraesophageal (EE) manifestations of GERD, including laryngopharyngeal ...
    • Is having asthma associated with an increased risk of dying from cardiovascular disease? A prospective cohort study of 446 346 Taiwanese adults 

      Strand, Linn B; Tsai, Min Kuang; Wen, Chi Pang; Chang, Shu-Sen; Brumpton, Ben Michael (Journal article; Peer reviewed, 2018)
      Objectives A significant proportion of cardiovascular disease (CVD) cannot be explained by well-known risk factors such as high cholesterol, hypertension and diabetes. One potential novel risk factor for CVD is asthma. We ...
    • Is individual practice in an immersive and interactive virtual reality application non-inferior to practicing with traditional equipment in learning systematic clinical observation? A randomized controlled trial 

      Berg, Helen; Steinsbekk, Aslak (Peer reviewed; Journal article, 2020)
      Background The aim was to investigate if individual self-practice of the ABCDE approach (Airways, Breathing, Circulation, Disability, Exposure) in an immersive and interactive virtual reality (VR) application gave ...
    • Is intracranial volume a risk factor for IDH-mutant low-grade glioma? A case-control study 

      Sagberg, Lisa Millgård; Fyllingen, Even Hovig; Hansen, Tor Ivar; Strand, Per Sveino; Håvik, Aril Løge; Sundstrøm, Terje; Corell, Alba; Jakola, Asgeir Store; Salvesen, Øyvind; Solheim, Ole (Peer reviewed; Journal article, 2022)
      Purpose Risk of cancer has been associated with body or organ size in several studies. We sought to investigate the relationship between intracranial volume (ICV) (as a proxy for lifetime maximum brain size) and risk of ...
    • Is more frequent physical therapy associated with increased gross motor improvement in children with cerebral palsy? A national prospective cohort study 

      Størvold, Gunfrid Vinje; Jahnsen, Reidun; Evensen, Kari Anne Indredavik; Bratberg, Grete Helen (Journal article; Peer reviewed, 2018)
      Purpose: To investigate the association between physical therapy frequency and gross motor improvement in children with cerebral palsy (CP). Materials and methods: This is a prospective cohort study of 442 children aged ...
    • Is physical activity maintenance from adolescence to young adulthood associated with reduced CVD risk factors, improved mental health and satisfaction with life: the HUNT Study, Norway 

      Rangul, Vegar; Bauman, Adrian; Holmen, Turid Lingaas; Midthjell, Kristian (Journal article; Peer reviewed, 2012)
      Background Little is known about the effect maintaining physical activity throughout adolescence has on cardiovascular risk factors and health status in early adulthood. This ten-year prospective longitudinal study ...
    • Is police investigation of rape biased by characteristics of victims? 

      Vik, Bjarte Frode; Rasmussen, Kirsten; Schei, Berit; Hagemann, Cecilie Therese (Peer reviewed; Journal article, 2020)
      Aim To explore differences in police investigations between cases of rape against women with and without vulnerability factors. Methods Retrospective, descriptive study of cases of rape against women ≥16 years of age. ...
    • Is smoking heaviness causally associated with alcohol use? A Mendelian randomization study in four European cohorts 

      Taylor, Michelle; Rode, Line; Bjørngaard, Johan Håkon; Taylor, Amy E.; Bojesen, Stig E.; Åsvold, Bjørn Olav; Gabrielsen, Maiken Elvestad; Lewis, Glyn; Nordestgaard, Børge G.; Romundstad, Pål Richard; Hickman, Matthew; Munafò, Marcus R. (Journal article; Peer reviewed, 2018)
      Background Observational studies have shown that tobacco and alcohol use co-occur, but it is not clear whether this relationship is causal. Methods Using data from the Avon Longitudinal Study of Parents and Children ...
    • Is the Disease Burden from COPD in Norway Falling off? A Study of Time Trends in Three Different Data Sources 

      Melbye, Hasse; Helgeland, Jon; Karlstad, Øystein; Ariansen, Inger; Langhammer, Arnulf; Wisløff, Torbjørn; Nafstad, Per; Nystad, Wenche (Peer reviewed; Journal article, 2020)
      Background: Less smoking should lead to fewer COPD cases. We aimed at estimating time trends in the prevalence and burden of COPD in Norway from 2001 to 2017. Methods: We used pre-bronchodilator spirometry and other health ...