Browsing Institutt for nevromedisin og bevegelsesvitenskap by Title
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Genetic architecture of subcortical brain structures in 38,851 individuals
(Journal article, 2019)Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus ... -
Genetic studies of LRRK2 and PINK1 in Parkinson's disease
(Doktoravhandlinger ved NTNU, 1503-8181; 2007:48, Doctoral thesis, 2007)Background and objectives Parkinson’s disease (PD) is a common neurodegenerative disorder affecting 1% of the elderly. The disease causes a significant burden of illness and cost to society. The causes of PD have remained ... -
Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer's pathophysiology and susceptibility
(Journal article; Peer reviewed, 2015)Background Alzheimer’s disease is a neurodegenerative disorder in which extracellular deposition of β-amyloid (Aβ) oligomers causes synaptic injury resulting in early memory loss, altered homeostasis, accumulation of ... -
Genetics and Molecular Pathways in Parkinson's disease and Parkinsonism
(Doctoral theses at NTNU;2018:36, Doctoral thesis, 2018)In this thesis I used a wide range of genetic methodologies and biological strategies to unravel the genetic bases of parkinsonian disorders and their clinical relevance. First, in Paper I, we present the discovery of a ... -
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk
(Journal article; Peer reviewed, 2019)Alzheimer’s disease (AD) is highly heritable and recent studies have identified over 20 disease-associated genomic loci. Yet these only explain a small proportion of the genetic variance, indicating that undiscovered loci ... -
Gir ACE-hemmere og angiotensinreseptorantagonister økt risiko for alvorlig covid-19?
(Peer reviewed; Journal article, 2020)Hypertensjon og diabetes mellitus er risikofaktorer for alvorlig covid-19. Det er blitt reist spørsmål om hvorvidt denne assosiasjonen er relatert til bruk av ACE-hemmere og angiotensin II-reseptorblokkere. -
Gir styrketrening av kne- og hoftemuskulatur med bevegelsesrestriksjoner større bedring av smerte og funksjon enn styrketrening av kne- og hoftemuskulatur uten bevegelsesrestriksjoner for individer med patellofemoralt smertesyndrom?
(Bachelor thesis, 2020)Hensikt: Se om styrketrening av kne- og hoftemuskulatur med bevegelsesrestriksjoner gir større bedring av smerte og funksjon enn styrketrening av kne- og hoftemuskulatur uten bevegelsesrestriksjoner for individer med ... -
Glia-neuron interactions underlie state transitions to generalized seizures
(Journal article; Peer reviewed, 2019)Brain activity and connectivity alter drastically during epileptic seizures. The brain networks shift from a balanced resting state to a hyperactive and hypersynchronous state. It is, however, less clear which mechanisms ... -
Glial activation and inflammation along the Alzheimer's disease continuum
(Journal article; Peer reviewed, 2019)Background Neuronal and glial cell interaction is essential for synaptic homeostasis and may be affected in Alzheimer’s disease (AD). We measured cerebrospinal fluid (CSF) neuronal and glia markers along the AD continuum, ... -
Glial-Neuronal Interactions in Animal Models of Neurological Disorders that Primarily Affect Children
(Doktoravhandlinger ved NTNU, 1503-8181; 2013:17, Doctoral thesis, 2013) -
Glial-neuronal interactions in experimental brain disorders
(Doktoravhandlinger ved NTNU, 1503-8181; 2005:137, Doctoral thesis, 2005)When [1-13C]glucose and [1,2- 13C]acetate are given simultaneously, information of astrocytic and neuronal metabolism can be obtained in the same animal. This is because acetate is exclusively taken up by astrocytes, while ... -
Glioblastoma Segmentation: Comparison of Three Different Software Packages
(Journal article; Peer reviewed, 2016)To facilitate a more widespread use of volumetric tumor segmentation in clinical studies, there is an urgent need for reliable, user-friendly segmentation software. The aim of this study was therefore to compare three ... -
Global, regional, and national burden of migraine and tension-type headache, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016
(Journal article; Peer reviewed, 2018)Background Through the Global Burden of Diseases, Injuries, and Risk Factors (GBD) studies, headache has emerged as a major global public health concern. We aimed to use data from the GBD 2016 study to provide new estimates ... -
Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016
(Journal article; Peer reviewed, 2019)Background: Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is ... -
Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015
(Journal article; Peer reviewed, 2016)Background: Healthy life expectancy (HALE) and disability-adjusted life-years (DALYs) provide summary measures of health across geographies and time that can inform assessments of epidemiological patterns and health system ... -
Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.
(Journal article; Peer reviewed, 2018)Background How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, ... -
Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015
(Journal article; Peer reviewed, 2016)Background Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological transition in many countries ... -
Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
(Journal article; Peer reviewed, 2017)BACKGROUND: As mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of ... -
Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
(Journal article; Peer reviewed, 2018)Background: The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) includes a comprehensive assessment of incidence, prevalence, and years lived with disability (YLDs) for 354 causes in 195 countries ... -
Glutamate and GABA: Major Players in Neuronal Metabolism
(Doktoravhandlinger ved NTNU, 1503-8181; 2007:39, Doctoral thesis, 2007)Disturbance of neuronal metabolism has implications for a number of neurological and psychiatric conditions, and enhanced knowledge of this is important in developing new methods for treating such disorders. The present ...