• Longitudinal study of the effect of a 5-year exercise intervention on structural brain complexity in older adults. A Generation 100 substudy 

      Pani, Jasmine; Marzi, Chiara; Stensvold, Dorthe; Wisløff, Ulrik; Håberg, Asta; Diciotti, Stefano (Peer reviewed; Journal article, 2022)
      Physical inactivity has been identified as an important risk factor for dementia. High levels of cardiorespiratory fitness (CRF) have been shown to reduce the risk of dementia. However, the mechanism by which exercise ...
    • Longitudinal trajectories of functional recovery after hip fracture 

      Dakhil, Shams; Saltvedt, Ingvild Tina; Saltyte Benth, Jurate; Thingstad, Anne Pernille Mæhle; Watne, Leiv; Wyller, Torgeir Bruun; Helbostad, Jorunn Hege Lægdheim; Frihagen, Frede; Johnsen, Lars Gunnar; Taraldsen, Kristin (Peer reviewed; Journal article, 2023)
      Background There is limited evidence regarding predictors of functional trajectories after hip fracture. We aimed to identify groups with different trajectories of functional recovery the first year after hip fracture, ...
    • Long‐term changes in self‐reported sleep quality and risk of chronic musculoskeletal pain: The HUNT Study 

      Skarpsno, Eivind S.; Nilsen, Tom Ivar Lund; Hagen, Knut; Mork, Paul Jarle (Peer reviewed; Journal article, 2021)
      We examined the association between long‐term (~10 years) changes in self‐reported sleep quality and risk of any chronic musculoskeletal pain and chronic widespread pain. The study comprised data on 6,033 people who ...
    • Long‐term efficacy and safety of biosimilar infliximab (CT‐P13) after switching from originator infliximab: Open‐label extension of the NOR‐SWITCH trial 

      Goll, Guro Løvik; Jørgensen, Kristin Kaasen; Sexton, Joseph; Olsen, Inge Christoffer; Bolstad, Nils; Haavardsholm, Espen A.; Lundin, Knut Erik Aslaksen; Tveit, Kåre Steinar; Lorentzen, Merete; Berset, Ingrid Prytz; Fevang, Bjørg-Tilde Svanes; Kalstad, Synnøve; Ryggen, Kristin; Warren, David; Klaasen, Rolf; Asak, Øivind Wessel; Baigh, Somyeh; Blomgren, Ingrid; Brenna, Øystein; Bruun, Trude J; Dvergsnes, Katrine; Frigstad, Svein Oskar; Myrnes, Inger; Hatten, Ingvild Helgheim; Huppertz-Hauss, Gert; Henriksen, Magne; Hoie, Sunniva S.; Krogh, Jan Reidar; Midtgard, Irina P.; Mielnik, Pawel; Moum, Bjørn; Noraberg, Geir; Poyan, Armin; Prestegård, Ulf; Rashid, Haroon Ur; Strand, Eldri Kveine; Skjetne, Kristine; Seeberg, Kathrine; Torp, Roald; Ystrøm, Carl Magnus; Vold, Cecilia; Zettel, Camilla C.; Waksvik, Kenneth; Gulbrandsen, Bjørn; Hagfors, Jon; Mørk, Cato; Jahnsen, Jørgen; Kvien, Tore Kristian (Journal article; Peer reviewed, 2019)
      Background and objectives The 52‐week, randomized, double‐blind, noninferiority, government‐funded NOR‐SWITCH trial demonstrated that switching from infliximab originator to less expensive biosimilar CT‐P13 was not ...
    • Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity 

      Hotz, Adriana L.; Jamali, Ahmed; Rieser, Nicolas N.; Niklaus, Stephanie; Aydin, Ecem; Myren-Svelstad, Sverre; Lalla, Laetitia Noelle Patricia; Jurisch-Yaksi, Nathalie; Yaksi, Emre; Neuhauss, Stephan C.F. (Peer reviewed; Journal article, 2021)
      Astroglial excitatory amino acid transporter 2 (EAAT2, GLT-1, and SLC1A2) regulates the duration and extent of neuronal excitation by removing glutamate from the synaptic cleft. Hence, an impairment in EAAT2 function could ...
    • Loss or mislocalization of aquaporin-4 affects diffusion properties and intermediary metabolism in gray matter of mice 

      Pavlin, Tina; Nagelhus, Erlend Arnulf; Brekken, Christian; Eyjolfsson, Elvar M.; Thoren, Anna; Haraldseth, Olav; Sonnewald, Ursula; Ottersen, Ole Petter; Håberg, Asta (Journal article; Peer reviewed, 2017)
      The first aim of this study was to determine how complete or perivascular loss of aquaporin-4 (AQP4) water channels affects membrane permeability for water in the mouse brain grey matter in the steady state. Time-dependent ...
    • Low Back Pain With Persistent Radiculopathy; the Clinical Role of Genetic Variants in the Genes SOX5, CCDC26/GSDMC and DCC 

      Lie, Marie; Pedersen, Linda Margareth; Heuch, Ingrid; Winsvold, Bendik K S; Gjerstad, Johannes; Hasvik, Eivind Olay; Nygaard, Øystein Petter; Grotle, Margreth; Matre, Dagfinn; Zwart, John Anker Henrik; Nilsen, Kristian Bernhard (Peer reviewed; Journal article, 2022)
      In a recently published genome-wide association study (GWAS) chronic back pain was associated with three loci; SOX5, CCDC26/GSDMC and DCC. This GWAS was based on a heterogeneous sample of back pain disorders, and it is ...
    • Low bone mineral density is a significant risk factor for low-energy distal radius fractures in middle-aged and elderly men: A case-control study 

      Øyen, Jannike; Rohde, Gudrun Elin; Hochberg, Marc C.; Johnsen, Villy; Haugeberg, Glenn (Journal article; Peer reviewed, 2011)
      Background: In general there is a lack of data on osteoporosis and fracture in men; this also includes low-energy distal radius fractures. The objectives of this study were to examine BMD and identify factors associated ...
    • Low grade albuminuria as a risk factor for subtypes of stroke - the HUNT Study in Norway 

      Horn, Jens; Romundstad, Solfrid; Ellekjær, Hanne; Janszky, Imre; Horn, Julie (Peer reviewed; Journal article, 2020)
      Background and purpose Albuminuria is a marker for endothelial dysfunction and knowledge on its association with stroke and stroke subtypes are limited. Methods Corresponding data from 7261 participants of the ...
    • Low Grade Gliomas in Eloquent Locations – Implications for Surgical Strategy, Survival and Long Term Quality of Life 

      Jakola, Asgeir S; Unsgård, Geirmund; Myrmel, Kristin Smistad; Kloster, Roar; Torp, Sverre Helge; Lindal, Sigurd; Solheim, Ole (Journal article; Peer reviewed, 2012)
      Background: Surgical management of suspected LGG remains controversial. A key factor when deciding a surgical strategy is often the tumors’ perceived relationship to eloquent brain regions Objective: To study the association ...
    • Lower limb muscle fatigue during walking in children with cerebral palsy 

      Eken, Maaike M.; Brændvik, Siri Merete; Bardal, Ellen Marie; Houdijk, Han; Dallmeijer, Annet J.; Roeleveld, Karin (Journal article; Peer reviewed, 2018)
      Aim To investigate whether more prominent signs of muscle fatigue occur during self‐paced walking in children with cerebral palsy (CP) compared to typically developing peers. Method In this case–control study, 13 ...
    • Lower Limb Transtibial Prosthetic Socket Transversal Rotation Resistance – Comparison of Five Different Suspension Systems in a Mock Limb 

      Modalsli, Eivind; Tan, Alex; Bakke, Marie Langnes; Roeleveld, Karin; Eikevåg, Sindre Wold; Kohtala, Sampsa; Aasland,Knut Einar; Steinert, Martin (Master thesis, 2021)
      SAMMENDRAG Introduksjon. Komfort og stabilitet er viktige faktorer ved tilvirkning av protesehylse til amputasjonsstumpen hos personer med amputasjon av underekstremiteten og påvirkes av trykk, forskyvning og friksjon. ...
    • Lower regulatory frequency for postural control in patients with fibromyalgia and chronic fatigue syndrome 

      Rasouli, Omid; Vasseljen, Ottar; Fors, Egil A; Lorås, Håvard; Stensdotter, Ann-Katrin (Journal article; Peer reviewed, 2018)
      As many similar symptoms are reported in fibromyalgia (FM) and chronic fatigue syndrome (CFS), underlying defcits may potentially also be similar. Postural disequilibrium reported in both conditions may thus be explained ...
    • Lower-Grade Gliomas: An Epidemiological Voxel-Based Analysis of Location and Proximity to Eloquent Regions 

      Gómez Vecchio, Tomás; Neimantaite, Alice; Corell, Alba; Bartek, Jiri; Jensdottir, Margret; Reinertsen, Ingerid; Solheim, Ole; Jakola, Asgeir S. (Peer reviewed; Journal article, 2021)
      Background: Glioma is the most common intra-axial tumor, and its location relative to critical areas of the brain is important for treatment decision-making. Studies often report tumor location based on anatomical taxonomy ...
    • LRRTM3 Interacts with APP and BACE1 and Has Variants Associating with Late-Onset Alzheimer's Disease (LOAD) 

      Lincoln, Sarah; Allen, Mariet; Cox, Claire L.; Walker, Louise P.; Malphrus, Kimberly; Qiu, Yishu; Nguyen, Thuy; Rowley, Christopher; Kouri, Naomi; Crook, Julia; Pankratz, V. Shane; Younkin, Samuel; Younkin, Linda; Carrasquillo, Minerva; Zou, Fang Geng; Abdul-Hay, Samer O.; Springer, Wolfdieter; Sando, Sigrid Botne; Aasly, Jan; Barcikowska, Maria; Wszolek, Zbigniew K.; Lewis, Jada M.; Dickson, Dennis; Graff-Radford, Neil R.; Petersen, Ronald C.; Eckman, Elizabeth; Younkin, Steven G.; Ertekin-Taner, Nilüfer (Journal article; Peer reviewed, 2013)
      Leucine rich repeat transmembrane protein 3 (LRRTM3) is member of a synaptic protein family. LRRTM3 is a nested gene within α-T catenin (CTNNA3) and resides at the linkage peak for late-onset Alzheimer’s disease (LOAD) ...
    • Lumbar spinal stenosis, assessing failure and worsening after surgery. Identifying predictive factors with critical use of data from a national spine registry (NORspine) 

      Alhaug, Ole Kristian (Doctoral theses at NTNU;2023:210, Doctoral thesis, 2023)
      Norsk sammendrag Spinal stenose er en vanlig lidelse som skyldes trang ryggmargskanal og karakteriseres av smerter i rygg og bein og redusert gangfunksjon. Operasjon er ofte nødvendig og spinal stenose er den hyppigste ...
    • Lumbar total disc replacement: predictors for long-term outcome 

      Furunes, Håvard; Hellum, Christian; Brox, Jens Ivar; Rossvoll, Ivar; Espeland, Ansgar; Berg, Linda; Brøgger, Helga Maria; Småstuen, Milada C; Storheim, Kjersti (Journal article; Peer reviewed, 2017)
      Purpose We aimed to identify patient characteristics associated with favourable long-term outcomes after lumbar total disc replacement (TDR). Methods We analysed a cohort of 82 patients with degenerative disc and ...
    • Lydforhold i videregående skoler 

      Bårdsen, Marianne; Årvåg, Ida Beyer; Fjølstad, Jørgen (Bachelor thesis, 2019)
      “Lydforhold i videregående skoler” er oppgavens tittel. Å høre er en forutsetning for å lære. Gode akustiske forhold er viktig for læring, og spesielt i skolen er gode lydforhold svært viktig da innlæringen i stor grad ...
    • Machine learning algorithms performed no better than regression models for prognostication in traumatic brain injury 

      Gravesteijn, BY; Nieboer, Daan; Ercole, Ari; Lingsma, Hester F; Nelson, David; Van Calster, Ben; Steyerberg, Ewout W; Andelic, Nada; Anke, Audny; Frisvold, Shirin; Helseth, Eirik; Røe, Cecilie; Røise, Olav; Skandsen, Toril; Vik, Anne (Peer reviewed; Journal article, 2020)
      Objective We aimed to explore the added value of common machine learning (ML) algorithms for prediction of outcome for moderate and severe traumatic brain injury. Study Design and Setting We performed logistic regression ...
    • A Machine Learning Classifier for Detection of Physical Activity Types and Postures During Free-Living 

      Bach, Kerstin; Kongsvold, Atle Austnes; Bårdstu, Hilde Bremseth; Bardal, Ellen Marie; Kjærnli, Håkon Slåtten; Herland, Sverre; Logacjov, Aleksej; Mork, Paul Jarle (Journal article; Peer reviewed, 2021)
      Accelerometer-based measurements of physical activity types are commonly used to replace self-reports. To advance the field, it is desirable that such measurements allow accurate detection of key daily physical activity ...