• A complement C3–Specific nanobody for modulation of the alternative cascade identifies the C-Terminal domain of C3b as functional in C5 convertase activity 

      Pedersen, Henrik; Jensen, Rasmus K.; Jensen, Jens Magnus B.; Fox, Rachel; Pedersen, Dennis V.; Olesen, Heidi G.; Hansen, Annette G.; Christiansen, Dorte; Mazarakis, Sofia M.M.; Lojek, Neal; Hansen, Pernille; Gadeberg, Trine A.F.; Zarantonello, Alessandra; Laursen, Nick S.; Mollnes, Tom Eirik; Johnson, Matthew B.; Stevens, Beth; Thiel, Steffen; Andersen, Gregers R. (Peer reviewed; Journal article, 2020)
      The complement system is an intricate cascade of the innate immune system and plays a key role in microbial defense, inflammation, organ development, and tissue regeneration. There is increasing interest in developing ...
    • Heme Interferes With Complement Factor I-Dependent Regulation by Enhancing Alternative Pathway Activation 

      Gerogianni, Alexandra; Dimitrov, Jordan D.; Zarantonello, Alessandra; Poillerat, Victoria; Chonat, Satheesh; Sandholm, Kerstin; McAdam, Karin E.; Ekdahl, Kristina N.; Mollnes, Tom Eirik; Mohlin, Camilla; Roumenina, Lubka T.; Nilsson, Per (Peer reviewed; Journal article, 2022)
      Hemolysis, as a result of disease or exposure to biomaterials, is characterized by excess amounts of cell-free heme intravascularly and consumption of the protective heme-scavenger proteins in plasma. The liberation of ...