Blar i Institutt for klinisk og molekylær medisin på forfatter "Ye, Jing"
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Assessing the Role of TDG in the Hippocampus-dependent Memory using Transgenic Mouse Models and rAAV Viral Tools
Døskeland, Dagny Sanden (Master thesis, 2022)Tymin DNA-glykosylase (TDG) er et enzym med viktige roller i genomisk reperasjon og epigenetisk regulering. Tiltredende bevis indikerer en viktig rolle for TDG i aktiv DNA-demetylering. DNA-methylering har en regulerende ... -
DNA repair enzyme NEIL3 enables a stable neural representation of space by shaping transcription in hippocampal neurons
Kunath, Nicolas; Bugaj, Anna Maria; Bigonah, Pegah; Fernandez Berrocal, Marion Silvana; Bjørås, Magnar; Ye, Jing (Peer reviewed; Journal article, 2021)DNA repair enzymes are essential for the maintenance of the neuronal genome and thereby proper brain functions. Emerging evidence links DNA repair to epigenetic gene regulation; however, its contribution to different ... -
Entorhinal fast-spiking speed cells project to the hippocampus
Ye, Jing; Witter, Menno; Moser, May-Britt; Moser, Edvard Ingjald (Journal article; Peer reviewed, 2018)The mammalian positioning system contains a variety of functionally specialized cells in the medial entorhinal cortex (MEC) and the hippocampus. In order for cells in these systems to dynamically update representations in ... -
Impact of NEIL3 on neuronal maturation and organization in the hippocampal formation (HF) and medial entorhinal cortex (MEC)
Vankova, Ana (Master thesis, 2019)DNA damage is proposed to be the reason for mutations to occur. Base excision repair (BER) is the main pathway utilized by the brain to repair oxidative DNA damage. Defects in BER have been linked to the development of ... -
The impact of the DNA glycosylase NEIL3 on neural coding of spatial learning and memory
Kunath, Nicolas (Doctoral theses at NTNU;2021:1, Doctoral thesis, 2021) -
A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment
Lin, Xiaolin; Wang, Wei; Yang, Mingyi; Damseh, Nadirah; Sousa, Mirta; Jacob, Fadi; lång, anna ulrika; Kristiansen, Elise; Pannone, Marco; Kissova, Miroslava; Almaas, Runar; Kusnierczyk, Anna; Siller, Richard; Shahrour, Maher; Al-Ashhab, Motee; Abu-Libdeh, Bassam; Tang, Wannan; Slupphaug, Geir; Elpeleg, Orly; Bøe, Stig Ove; Eide, Lars; Sullivan, Gareth John; Rinholm, Johanne Egge; Song, Hongjun; Ming, Guo-li; van Loon, Barbara; Edvardson, Simon; Ye, Jing; Bjørås, Magnar (Peer reviewed; Journal article, 2023)Background Oxidation Resistance 1 (OXR1) gene is a highly conserved gene of the TLDc domain-containing family. OXR1 is involved in fundamental biological and cellular processes, including DNA damage response, antioxidant ... -
NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice
Hildrestrand, Gunn Annette; Rolseth, Veslemøy; Kunath, Nicolas; Suganthan, Rajikala; Jensen, Vidar; Bugaj, Anna Maria; Fernandez Berrocal, Marion Silvana; SIkko, Sunniva Bøe; Vetlesen, Susanne; Kusnierczyk, Anna; Olsen, Ann-Karin Hardie; Gutzkow, Kristine Bjerve; Rowe, Alexander D.; Wang, Wei; Moldestad, Olve; Syrstad, Monika; Slupphaug, Geir; Eide, Lars; Klungland, Arne; Sætrom, Pål; Luna, Luisa; Ye, Jing; Scheffler, Katja; Bjørås, Magnar (Peer reviewed; Journal article, 2021)Oxidative DNA damage in the brain has been implicated in neurodegeneration and cognitive decline. DNA glycosylases initiate base excision repair (BER), the main pathway for oxidative DNA base lesion repair. NEIL1 and NEIL3 ... -
Parp3 promotes astrocytic differentiation through a tight regulation of Nox4-induced ROS and mTorc2 activation
Rodriguez-Vargas, José-Manuel; Martin-Hernandez, Kathline; Wang, Wei; Kunath, Nicolas; Suganthan, Rajikala; Amé, Jean-Christophe; Francisco, Javier Oliver Pozo; Ye, Jing; Bjørås, Magnar; Dantzer, Françoise (Peer reviewed; Journal article, 2020)Parp3 is a member of the Poly(ADP-ribose) polymerase (Parp) family that has been characterized for its functions in strand break repair, chromosomal rearrangements, mitotic segregation and tumor aggressiveness. Yet its ... -
The functional role of NEIL3 DNA glycosylase in the hippocampus
Heggedal, Mina (Master thesis, 2022)Tiltagende bevis tyder på at NEIL3 har viktige funksjoner i hjernen. Studier med gnagere har avslørt et diskret ekspresjonsmønster av NEIL3 i den subgranulære sonen av dentate gyrus og i den subventrikulære sonen av de ... -
The role of TDG-mediated DNA demethylation in the entorhinal-hippocampal spatial representation system
Innvær, Konstanse Skogøy (Master thesis, 2022)Hukommelsestap og kognitive svekkelser er ofte sett med aldring. Degenerasjonen sees ofte i sammenheng med epigenetisk endring, som i DNA metylering og demetylering. Flere studier som omhandler 5-hydroxymethylcytosine ...