Blar i Institutt for klinisk og molekylær medisin på forfatter "Salvesen, Øyvind"
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Angiogenesis and radiological tumor growth in patients with glioblastoma
Mikkelsen, Vilde Elisabeth; Stensjøen, Anne Line; Granli, Unn Sophie; Berntsen, Erik Magnus; Salvesen, Øyvind; Solheim, Ole; Torp, Sverre Helge (Journal article; Peer reviewed, 2018)Background The preoperative growth of human glioblastomas (GBMs) has been shown to vary among patients. In animal studies, angiogenesis has been linked to hypoxia and faster growth of GBM, however, its relation to the ... -
Boys and girls differ in symptoms and neurodevelopmental outcome after perinatal metabolic acidosis, a population-based study
Hafström, Maria; Salvesen, Øyvind; Kjellmer, Ingemar (Peer reviewed; Journal article, 2018)Aim To evaluate sex differences in infants born at term with metabolic acidosis with regard to perinatal health and symptomatology, and developmental outcome. Methods From a population-based cohort of infants born at ... -
Bronchoalveolar lavage fluid IFN- γ + Th17 cells and regulatory T cells in pulmonary sarcoidosis
Tøndell, Anders; Moen, Torolf; Børset, Magne; Salvesen, Øyvind; Rø, Anne Dorthea; Sue-Chu, Malcolm (Journal article; Peer reviewed, 2014)In sarcoidosis, increased Th17 cell fractions have been reported in bronchoalveolar lavage fluid, and elevated numbers of Th17 cells producing IFN-𝛾 have been observed in peripheral blood. The balance between Th1, Th17, ... -
Caesarean section performed by medical doctors and associate clinicians in Sierra Leone
van Duinen, Aalke Johan; Kamara, Michael M.; Hagander, Lars; Ashley, Thomas; Koroma, Alimamy Philip; Leather, Andy J.M.; Elhassein, Mohammed; Darj, Elisabeth; Salvesen, Øyvind; Wibe, Arne; Bolkan, Håkon Angell (Journal article; Peer reviewed, 2019)Background Many countries lack sufficient medical doctors to provide safe and affordable surgical and emergency obstetric care. Task‐sharing with associate clinicians (ACs) has been suggested to fill this gap. The aim ... -
Comparative effectiveness of microdecompression and laminectomy for central lumbar spinal stenosis: Study protocol for an observational study
Nerland, Ulf Skule; Jakola, Asgeir Store; Solheim, Ole; Weber, Clemens; Rao, Vidar; Lønne, Greger; Solberg, Tore; Salvesen, Øyvind; Carlsen, Sven Magnus; Nygaard, Øystein Petter; Gulati, Sasha (Journal article; Peer reviewed, 2014)Introduction: This observational study is designed to test the equivalence between the clinical effectiveness of microdecompression and laminectomy in the surgical treatment of central lumbar spinal stenosis. Lumbar spinal ... -
Correlation Between Digital and Manual Determinations of Ki-67/MIB-1 Proliferative Indices in Human Meningiomas
Pham, Duc-Tien; Skaland, Ivar; Winther, Theo L.; Salvesen, Øyvind; Torp, Sverre Helge (Peer reviewed; Journal article, 2019)Objective. Proliferative activity in tumor tissues is assessed as the percentage of Ki-67/MIB-1-positive cells, or the proliferative index (PI). The PI is routinely assessed manually. However, the subjectivity of manual ... -
Dietary Intake in Early Pregnancy and Glycemia in Late Pregnancy among Women with Obesity
Garnæs, Kirsti Krohn; Elvebakk, Trude; Salvesen, Øyvind; Stafne, Signe Nilssen; Mørkved, Siv; Salvesen, Kjell Å; Moholdt, Trine (Peer reviewed; Journal article, 2021)Women with obesity have increased risk for hyperglycemia during pregnancy, with negative health consequences for mother and child. We aimed to investigate adherence to nutritional recommendations in early pregnancy and to ... -
Disulfiram repurposing combined with nutritional copper supplement as add-on to chemotherapy in recurrent glioblastoma (DIRECT): Study protocol for a randomized controlled trial
Jakola, Asgeir S.; Werlenius, Katja; Mudaisi, Munila; Hylin, Sofia; Kinhult, Sara; bartek, Jiri Jr.; Salvesen, Øyvind; Carlsen, Sven Magnus; Strandeus, Michael; Lindskog, Magnus; Lofgren, David; Rydenhaug, Bertil; Carstam, Louise; Gulati, Sasha; Solheim, Ole; Bartek, Jiri; Solheim, Tora Skeidsvoll (Journal article; Peer reviewed, 2018)Background: Disulfiram (DSF) is a well-tolerated, inexpensive, generic drug that has been in use to treat alcoholism since the 1950s. There is now independent preclinical data that supports DSF as an anticancer agent, and ... -
Effect of a multifaceted educational program for care staff concerning fecal incontinence in nursing home patients: Study protocol of a cluster randomized controlled trial
Blekken, Lene Elisabeth; Vinsnes, Anne Guttormsen; Gjeilo, Kari Hanne; Mørkved, Siv; Salvesen, Øyvind; Norton, Christine; Nakrem, Sigrid (Journal article; Peer reviewed, 2015)Background Fecal incontinence has a high prevalence in the older population, which cannot be explained by comorbidity or the anatomical or psychological changes of aging alone. Fecal incontinence leads to a high economic ... -
Effect of intranasal oxytocin on alcohol withdrawal syndrome: A randomized placebo-controlled double-blind clinical trial
Melby, Katrine; Gråwe, Rolf W.; Aamo, Trond Oskar; Salvesen, Øyvind; Spigset, Olav (Peer reviewed; Journal article, 2019)Background In a pilot study, intranasal oxytocin was demonstrated to reduce the benzodiazepine dose needed to relieve withdrawal symptoms during alcohol detoxification. The aim of the present study was to compare the ... -
The effect of preoperative pelvic floor muscle training on urinary and colorectal-anal distress in women undergoing pelvic organ prolapse surgery—a randomized controlled trial
Mathew, Seema; Nyhus, Maria Øyasæter; Salvesen, Øyvind; Salvesen, Kjell Å; Stafne, Signe Nilssen; Volløyhaug, Ingrid (Peer reviewed; Journal article, 2021)Introduction and hypothesis Pelvic floor muscle training (PFMT) improves urinary incontinence and mild pelvic organ prolapse (POP). We aimed to investigate the effect of preoperative PFMT on urinary and colorectal-anal ... -
Effect of Spinal Cord Burst Stimulation vs Placebo Stimulation on Disability in Patients With Chronic Radicular Pain After Lumbar Spine Surgery: A Randomized Clinical Trial
Hara, Sozaburo; Andresen, Hege; Solheim, Ole; Carlsen, Sven Magnus; Sundstrøm, Terje; Lønne, Greger; Vangen-Lønne, Vetle; Taraldsen, Kristin; Tronvik, Erling Andreas; Øie, Lise Rystad; Gulati, Agnete Malm; Sagberg, Lisa Millgård; Jakola, Asgeir Store; Solberg, Tore; Nygaard, Øystein Petter; Salvesen, Øyvind; Gulati, Sasha (Peer reviewed; Journal article, 2022)Importance: The use of spinal cord stimulation for chronic pain after lumbar spine surgery is increasing, yet rigorous evidence of its efficacy is lacking. Objective: To investigate the efficacy of spinal cord burst ... -
Effect of supervised exercise training during pregnancy on neonatal and maternal outcomes among overweight and obese women. Secondary analyses of the ETIP trial: A randomised controlled trial
Garnæs, Kirsti Krohn; Nyrnes, Siri Ann; Salvesen, Kjell Å; Salvesen, Øyvind; Mørkved, Siv; Moholdt, Trine (Journal article; Peer reviewed, 2017)Background Maternal obesity associates with complications during pregnancy and childbirth. Our aim was to investigate if exercise during pregnancy in overweight/obese women could influence birth weight or other neonatal ... -
Effects of supervised exercise training during pregnancy on psychological well-being among overweight and obese women: secondary analyses of the ETIP-trial, a randomised controlled trial
Garnæs, Kirsti Krohn; Helvik, Anne-Sofie; Stafne, Signe Nilssen; Mørkved, Siv; Salvesen, Kjell Å; Salvesen, Øyvind; Moholdt, Trine (Journal article; Peer reviewed, 2019)Objectives Women with high body mass index (BMI) have increased risk for symptoms of anxiety and depression during pregnancy and postpartum. In this prespecified secondary analysis from the exercise training in pregnancy ... -
Evaluation of a surgical task sharing training programme's logbook system in Sierra Leone
Svendsen, Øyvind Veel; Helgerud, C; van Duinen, Aalke Johan; Salvesen, Øyvind; George, Peter M.; Bolkan, Håkon Angell (Journal article; Peer reviewed, 2019)Background Personal logbooks are universally applied for monitoring and evaluation of surgical trainees; however, the quality and accuracy of such logbooks in low income countries (LICs) are poorly examined. Logbooks ... -
Exercise training during pregnancy reduces circulating insulin levels in overweight/obese women postpartum: secondary analysis of a randomised controlled trial (the ETIP trial)
Garnæs, Kirsti Krohn; Mørkved, Siv; Salvesen, Kjell Å; Salvesen, Øyvind; Moholdt, Trine (Journal article; Peer reviewed, 2018)Background The primary aim was to investigate if supervised exercise training during pregnancy could reduce postpartum weight retention (PPWR) three months after delivery in overweight and obese women. We also measured ... -
Feasibility and accuracy of point-of-care pocket-size ultrasonography performed by medical students
Andersen, Garrett Newton; Viset, Annja Torlaug; Mjølstad, Ole Christian; Salvesen, Øyvind; Dalen, Håvard; Haugen, Bjørn Olav (Journal article; Peer reviewed, 2014)Background Point-of-care ultrasound performed by clinicians is a useful supplement in the treatment and assessment of patients. We aimed to investigate whether medical students with minimal training were able to successfully ... -
Fetal growth and birth anthropometrics in metformin exposed offspring born to mothers with PCOS
Hjorth-Hansen, Anna; Salvesen, Øyvind; Hanem, Liv Guro Engen; Eggebø, Torbjørn Moe; Salvesen, Kjell Å; Vanky, Eszter; Ødegård, Rønnaug (Journal article; Peer reviewed, 2017)Context Metformin is used in an attempt to reduce pregnancy complications associated with polycystic ovary syndrome (PCOS). Little is known about the effect of metformin on fetal development and growth. Objectives To ... -
The histological representativeness of glioblastoma tissue samples
Mikkelsen, Vilde Elisabeth; Solheim, Ole; Salvesen, Øyvind; Torp, Sverre Helge (Peer reviewed; Journal article, 2020)Background Glioblastomas (GBMs) are known for having a vastly heterogenous histopathology. Several studies have shown that GBMs can be histologically undergraded due to sampling errors of small tissue samples. We sought ... -
Improving reproductive function in women with polycystic ovary syndrome with high-intensity interval training (IMPROV-IT): study protocol for a two-centre, three-armed randomised controlled trial.
Kiel, Ida Almenning; Lionett, Sofie Buurgaard; Parr, Evelyn B.; Jones, Helen; Røset, Maria Aurora Hernandez; Salvesen, Øyvind; Vanky, Eszter; Moholdt, Trine (Journal article; Peer reviewed, 2020)Introduction Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age and the leading cause of anovulatory infertility. Women with PCOS have a 15-fold higher prevalence of infertility, ...