• Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism 

      Arbore, Giuseppina; West, Erin; Rahman, Jubayer; Le Friec, Gaelle; Niyonzima, Nathalie; Mehdi, Pirooznia; Ilker, Tunc; Polychronis, Pavlidis; Nicholas, Powell; Li, Yuesheng; Liu, Poching; Servais, Aude; Couzi, Lionel; Fremeaux-Bacchi, Veronique; Placais, Leo; Ferraro, Alastair; Walsh, Patrick R.; Kavanagh, David; Afzali, Behdad; Lavender, Paul; Lachmann, Helen J.; Kemper, Claudia (Journal article; Peer reviewed, 2018)
      The induction of human CD4+ Th1 cells requires autocrine stimulation of the complement receptor CD46 in direct crosstalk with a CD4+ T cell-intrinsic NLRP3 inflammasome. However, it is unclear whether human cytotoxic CD8+ ...
    • Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation 

      Niyonzima, Nathalie; Rahman, Jubayer; Kunz, Natalie; West, Erin; Freiwald, Tilo; Desai, Jigar V.; Merle, Nicolas; Gidon, Alexandre; Sporsheim, Bjørnar; Lionakis, Michail S.; Evensen, Kristin; Lindberg, Beate; Skagen, Karolina; Skjelland, Mona; Singh, Parul; Haug, Markus; Ruseva, Marieta M.; Kolev, Martin; Bibby, Jack; Marshall, Olivia; O’Brien, Brett; Deeks, Nigel; Afzali, Behdad; Clark, Richard J.; Woodruff, Trent M.; Pryor, Mylton; Yang, Zhi-Hong; Remaley, Alan T.; Mollnes, Tom Eirik; Hewitt, Stephen M.; Yan, Bingyu; Kazemian, Majid; Kiss, Mate G.; Binder, Christoph J.; Halvorsen, Bente; Espevik, Terje; Kemper, Claudia (Peer reviewed; Journal article, 2021)
      While serum-circulating complement destroys invading pathogens, intracellularly active complement, termed the “complosome,” functions as a vital orchestrator of cell-metabolic events underlying T cell effector responses. ...