• Computational Drug Repositioning and Experimental Validation of Ivermectin in Treatment of Gastric Cancer 

      Rabben, Hanne-Line; Andersen, Gøran Troseth; Ianevski, Aleksandr; Olsen, Magnus Kringstad; Kainov, Denis; Grønbech, Jon Erik; Wang, Timothy Cragin; Chen, Duan; Zhao, Chun-Mei (Peer reviewed; Journal article, 2021)
      Objective: The aim of the present study was repositioning of ivermectin in treatment of gastric cancer (GC) by computational prediction based on gene expression profiles of human and mouse model of GC and validations with ...
    • Neural signaling modulates metabolism of gastric cancer 

      Rabben, Hanne-Line; Andersen, Gøran Troseth; Olsen, Magnus Kringstad; Øverby, Anders; Ianevski, Aleksandr; Kainov, Denis; Wang, Timothy Cragin; Lundgren, Steinar; Grønbech, Jon Erik; Chen, Duan; Zhao, Chun-Mei (Peer reviewed; Journal article, 2021)
      Tumors comprise cancer cells and the associated stromal and immune/inflammatory cells, i.e., tumor microenvironment (TME). Here, we identify a metabolic signature of human and mouse model of gastric cancer and show that ...
    • Translational Research on Gastric Cancer – Pharmacological Validations of Metabolism-Based Treatments 

      Rabben, Hanne-Line (Doctoral theses at NTNU;2022:66, Doctoral thesis, 2022)
      Bakgrunn/mål: Metabolsk reprogrammering er et kjennetegn for kreft og et lovende område for nyutvikling av kreftbehandling. Magekreft er den femte mest vanlige kreftformen på verdensbasis, og er den tredje dødeligste blant ...
    • Vagotomy and Gastric Tumorigenesis 

      Rabben, Hanne-Line; Zhao, Chun-Mei; Hayakawa, Yoku; Wang, Timothy C.; Chen, Duan (Journal article, 2016)
      Vagotomy reduces gastric acid secretion and was therefore introduced as a surgical treatment for peptic ulcers in the 1970s. Later, it was replaced by acid reducing medication, such as histamine type 2 (H2) receptor ...