• Characteristics of epigenetic aging across gestational and perinatal tissues 

      Dieckmann, Linda; Lahti-Pulkkinen, Marius; Kvist, Tuomas; Lahti, Jari; DeWitt, Peter E.; Cruceanu, Cristiana; Laivuori, Hannele; Sammallahti, Sara; Villa, Pia M.; Suomalainen-König, Sanna; Eriksson, Johan G.; Kajantie, Eero Olavi; Raikkönen, Katri; Binder, Elisabeth B.; Czamara, Darina (Peer reviewed; Journal article, 2021)
      Background: Epigenetic clocks have been used to indicate differences in biological states between individuals of same chronological age. However, so far, only few studies have examined epigenetic aging in newborns—especially ...
    • Genome-Wide Copy Number Variant and High-Throughput Transcriptomics Analyses of Placental Tissues Underscore Persisting Child Susceptibility in At-Risk Pregnancies Cleared in Standard Genetic Testing 

      Czamara, Darina; Cruceanu, Cristiana; Lahti-Pulkkinen, Marius; Dieckmann, Linda; Ködel, Maik; Sauer, Susann; Rex-Haffner, Monika; Sammallahti, Sara; Kajantie, Eero Olavi; Laivuori, Hannele; Lahti, Jari; Räikkönen, Katri; Binder, Elisabeth B. (Peer reviewed; Journal article, 2022)
      Several studies have shown that children from pregnancies with estimated first-trimester risk based on fetal nuchal translucency thickness and abnormal maternal serum pregnancy protein and hormone levels maintain a higher ...
    • Heavier smoking may lead to a relative increase in waist circumference: Evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium 

      Morris, Richard W.; Taylor, Amy E.; Fluharty, Meg E.; Bjørngaard, Johan Håkon; Åsvold, Bjørn Olav; Gabrielsen, Maiken Elvestad; Campbell, Archie; Marioni, Riccardo; Kumari, Meena; Korhonen, Tellervo; Männistö, Satu; Marques-Vidal, Pedro; Kaakinen, Marika; Cavadino, Alana; Postmus, Iris; Husemoen, Lise Lotte N.; Skaaby, Tea; Ahluwalia, Tarun Veer Singh; Treur, Jorien L.; Willemsen, Gonneke; Dale, Caroline; Wannamethee, S. Goya; Lahti, Jari; Palotie, Aarno; Räikkönen, Katri; McConnachie, Alex; Padmanabhan, Sandosh; Wong, Andrew; Dalgård, Christine; Paternoster, Lavinia; Ben-Shlomo, Yoav; Tyrrell, Jessica; Horwood, John; Fergusson, David M.; Kennedy, Martin A.; Nohr, Ellen A.; Christiansen, Lene; Kyvik, Kirsten Ohm; Kuh, Diana; Watt, Graham; Eriksson, Johan G.; Whincup, Peter H.; Vink, Jacqueline M.; Boomsma, Dorret I.; Smith, George Davey; Lawlor, Debbie; Linneberg, Allan; Ford, Ian; Jukema, J. Wouter; Power, Chris; Hyppönen, Elina; Jarvelin, Marjo-Riitta; Preisig, Martin; Borodulin, Katja; Kaprio, Jaakko; Kivimaki, Mika; Smith, Blair H.; Hayward, Caroline; Romundstad, Pål Richard; Sørensen, Thorkild I.A.; Munafo, Marcus R.; Sattar, Naveed (Journal article; Peer reviewed, 2015)
      Objectives: To investigate, using a Mendelian randomisation approach, whether heavier smoking is associated with a range of regional adiposity phenotypes, in particular those related to abdominal adiposity. Design: ...
    • Maternal exposure to childhood maltreatment and mental and behavioral disorders in children 

      Airikka, Aino; Lahti-Pulkkinen, Marius; Tuovinen, Soile; Heinonen, Kati; Lahti, Jari; Girchenko, Polina; Lähdepuro, Anna; Pyhälä, Riikka; Czamara, Darina; Villa, Pia; Laivuori, Hannele; Kajantie, Eero Olavi; Binder, Elisabeth B.; Räikkönen, Katri (Peer reviewed; Journal article, 2022)
      Exposure to maltreatment in childhood is associated with lifelong risk of mental and behavioral disorders. Whether the effects extend to the next generation remains unclear. We examined whether maternal exposure to childhood ...
    • Maternal haemoglobin levels in pregnancy and child DNA methylation: a study in the pregnancy and childhood epigenetics consortium 

      Ronkainen, Justiina; Heiskala, Anni; Vehmeijer, Florianne O.; Lowry, Estelle; Caramaschi, Doretta; Estrada Gutierrez, Guadalupe; Heiss, Jonathan A.; Hummel, Nadine; Keikkala, Elina; Kvist, Tuomas; Kupsco, Allison; Melton, Phillip E.; Pesce, Giancarlo; Soomro, Munawar Hussain; Vives-Usano, Marta; Baïz, Nour; Binder, Elisabeth B.; Czamara, Darina; Guxens, Mònica; Mustaniemi, Sanna; London, Stephanie J.; Rauschert, Sebastian; Vääräsmäki, Marja; Vrijheid, Martine; Ziegler, Anette-G.; Annesi-Maesano, Isabella; Bustamante, Mariona; Huang, Rae-Chi; Hummel, Sandra; Just, Allan C.; Kajantie, Eero Olavi; Lahti, Jari; Lawlor, Debbie A.; Räikkönen, Katri; Jarvelin, Marjo-Riitta; Felix, Janine F.; Sebert, Sylvain (Peer reviewed; Journal article, 2021)
      Altered maternal haemoglobin levels during pregnancy are associated with pre-clinical and clinical conditions affecting the fetus. Evidence from animal models suggests that these associations may be partially explained by ...
    • A polyepigenetic glucocorticoid exposure score at birth and childhood mental and behavioral disorders 

      Suarez, Anna; Lahti, Jari; Lahti-Pulkkinen, Marius; Girchenko, Polina; Czamara, Darina; Arloth, Janine; Malmberg, Anni LK.; Hämäläinen, Esa; Kajantie, Eero Olavi; Laivuori, Hannele; Villa, Pia M.; Reynolds, Rebecca M.; Provençal, Nadine; Binder, Elisabeth B.; Räikkönen, Katri (Peer reviewed; Journal article, 2020)
      Background Maternal depression and anxiety during pregnancy may enhance fetal exposure to glucocorticoids (GCs) and harm neurodevelopment. We tested whether a novel cross-tissue polyepigenetic biomarker indicative of in ...
    • Positive maternal mental health during pregnancy and mental and behavioral disorders in children: A prospective pregnancy cohort study 

      Lähdepuro, Anna; Lahti-Pulkkinen, Marius; Pyhälä, Riikka; Tuovinen, Soile; Lahti, Jari; Heinonen, Kati; Laivuori, Hannele; Villa, Pia M.; Reynolds, Rebecca M.; Kajantie, Eero Olavi; Girchenko, Polina; Räikkönen, Katri (Journal article; Peer reviewed, 2022)
    • A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation 

      Li, Shaobo; Spitz, Natalia; Ghantous, Akram; Abrishamcar, Sarina; Reimann, Brigitte; Marques, Irene; Silver, Matt J.; Aguilar-Lacasaña, Sofía; Kitaba, Negusse; Rezwan, Faisal I.; Röder, Stefan; Sirignano, Lea; Tuhkanen, Johanna; Mancano, Giulia; Sharp, Gemma C.; Metayer, Catherine; Morimoto, Libby; Stein, Dan J.; Zar, Heather J.; Alfano, Rossella; Nawrot, Tim; Wang, Congrong; Kajantie, Eero Olavi; Keikkala, Elina; Mustaniemi, Sanna; Ronkainen, Justiina; Sebert, Sylvain; Silva, Wnurinham; Vääräsmäki, Marja; Jaddoe, Vincent W. V.; Bernstein, Robin M.; Prentice, Andrew M.; Cosin-Tomas, Marta; Dwyer, Terence; Håberg, Siri Eldevik; Herceg, Zdenko; Magnus, Maria Christine; Munthe-Kaas, Monica Cheng; Page, Christian Magnus; Völker, Maja; Gilles, Maria; Send, Tabea; Witt, Stephanie; Zillich, Lea; Gagliardi, Luigi; Richiardi, Lorenzo; Czamara, Darina; Räikkönen, Katri; Chatzi, Lida; Vafeiadi, Marina; Arshad, S. Hasan; Ewart, Susan; Plusquin, Michelle; Felix, Janine F.; Moore, Sophie E.; Vrijheid, Martine; Holloway, John W.; Karmaus, Wilfried; Herberth, Gunda; Zenclussen, Ana; Streit, Fabian; Lahti, Jari; Hüls, Anke; Hoang, Thanh T.; London, Stephanie J.; Wiemels, Joseph L. (Peer reviewed; Journal article, 2024)
      Higher birth order is associated with altered risk of many disease states. Changes in placentation and exposures to in utero growth factors with successive pregnancies may impact later life disease risk via persistent DNA ...
    • The relationship between health-related quality of life and melancholic depressive symptoms is modified by brain insulin receptor gene network 

      Selenius, Jannica S.; Silveira, Patricia P.; Salonen, Minna K; Kautiainen, Hannu; von Bonsdorff, Mikaela; Kajantie, Eero Olavi; Lahti, Jari; Eriksson, Johan G.; Wasenius, N. S. (Peer reviewed; Journal article, 2021)
      To investigate whether expression-based polygenic risk scores for the insulin receptor gene network (ePRS-IRs) modifiy the association between type of depressive symptoms and health-related quality of life (HRQoL). This ...
    • Reliability of a novel approach for reference-based cell type estimation in human placental DNA methylation studies 

      Dieckmann, Linda; Cruceanu, Cristiana; Lahti-Pulkkinen, Marius; Lahti, Jari; Kvist, Tuomas; Laivuori, Hannele; Sammallahti, Sara; Villa, Pia M.; Suomalainen-König, Sanna; Rancourt, Rebecca C.; Plagemann, Andreas; Henrich, Wolfgang; Eriksson, Johan G.; Kajantie, Eero Olavi; Entringer, Sonja; Braun, Thorsten; Räikkönen, Katri; Binder, Elisabeth B.; Czamara, Darina (Peer reviewed; Journal article, 2022)
      The placenta is a central organ during early development, influencing trajectories of health and disease. DNA methylation (DNAm) studies of human placenta improve our understanding of how its function relates to disease ...