• Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT 

      Dabo, Stephanie; Maillard, Patrick; Rodriguez, Milagros Collados; Hansen, Marianne Dore; Mazouz, Sabrina; Bigot, Donna-Joe; Tible, Marion; Janvier, Geneviève; Helynck, Oliver; Cassonnet, Patricia; Jacob, Yves; Bellalou, Jacques; Gatignol, Anne; Patel, Rekha C; Hugon, Jacques; Munier-Lehmann, Hélène; Meurs, Eliane F. (Journal article; Peer reviewed, 2017)
      PKR is a cellular kinase involved in the regulation of the integrative stress response (ISR) and pro-inflammatory pathways. Two N-terminal dsRNA Binding Domains (DRBD) are required for activation of PKR, by interaction ...