Browsing Institutt for klinisk og molekylær medisin by Author "Aas, Per Arne"

Now showing items 1-18 of 18

    • AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature 

      Pettersen, Henrik Sahlin; Galashevskaya, Anastasia; Doseth, Berit; Sousa, Mirta; Sarno, Antonio; Visnes, Torkild; Aas, Per Arne; Liabakk, Nina-Beate; Slupphaug, Geir; Sætrom, Pål; Kavli, Bodil Merete; Krokan, Hans Einar (Journal article; Peer reviewed, 2014)
      tThe most common mutations in cancer are C to T transitions, but their origin has remained elusive.Recently, mutational signatures of APOBEC-family cytosine deaminases were identified in many com-mon cancers, suggesting ...

    • ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA 

      Wollen, Kristian Lied; Hagen, Lars; Vågbø, Cathrine Broberg; Rabe, Renana; Iveland, Tobias Solli; Aas, Per Arne; Sharma, Animesh; Sporsheim, Bjørnar; Erlandsen, Hilde O.; Palibrk, Vuk; Bjørås, Magnar; Fonseca, Davi de Miranda; Mosammaparast, Nima; Slupphaug, Geir (Peer reviewed; Journal article, 2021)
      Background: Reversible enzymatic methylation of mammalian mRNA is widespread and serves crucial regulatory functions, but little is known to what degree chemical alkylators mediate overlapping modifcations and whether cells ...

    • Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression 

      Montaldo, Nicola Pietro; Bordin, Diana Lilian; Brambilla, Alessandro; Rösinger, Marcel; Martin, Sarah Fordyce; Bjørås, Karine Øian; Bradamante, Stefano; Aas, Per Arne; Furrer, Antonia; Olsen, Lene Christin; Kunath, Nicolas; Otterlei, Marit; Sætrom, Pål; Bjørås, Magnar; Samson, Leona D.; van Loon, Barbara (Journal article; Peer reviewed, 2019)
      Base excision repair (BER) initiated by alkyladenine DNA glycosylase (AAG) is essential for removal of aberrantly methylated DNA bases. Genome instability and accumulation of aberrant bases accompany multiple diseases, ...

    • An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells 

      Sousa, Mirta; Zub, Kamila Anna; Aas, Per Arne; Hanssen-Bauer, Audun; Demirovic, Aida; Sarno, Antonio; Tian, Erming; Liabakk, Nina-Beate; Slupphaug, Geir (Journal article; Peer reviewed, 2013)
      Alterations in checkpoint and DNA repair pathways may provide adaptive mechanisms contributing to acquired drug resistance. Here, we investigated the levels of proteins mediating DNA damage signaling and -repair in RPMI8226 ...

    • Backbone 1H, 13C and 15N chemical shift assignment of full-length human uracil DNA glycosylase UNG2 

      Buchinger, Edith; Wiik, Siv Åshild; Kusnierczyk, Anna; Rabe, Renana; Aas, Per Arne; Kavli, Bodil Merete; Slupphaug, Geir; Aachmann, Finn Lillelund (Journal article; Peer reviewed, 2017)
      Human uracil N-glycosylase isoform 2—UNG2 consists of an N-terminal intrinsically disordered regulatory domain (UNG2 residues 1–92, 9.3 kDa) and a C-terminal structured catalytic domain (UNG2 residues 93–313, 25.1 kDa). ...

    • A fast, low-cost, robust and high-throughput method for viral nucleic acid isolation based on NAxtra magnetic nanoparticles 

      Ravlo, Erlend; Sousa, Mirta; Andresen, Lise Lima; Holberg-Petersen, Mona; Klundby, Ingvild; Aas, Per Arne; Hagen, Lars; Erlandsen, Sten Even; Fossum, Janne; Ali, Zeeshan; Sharma, Anuvansh; Ottesen, Vegar; Bandyopadhyay, Sulalit; Bjørås, Magnar (Peer reviewed; Journal article, 2023)
      The year of 2020 was profoundly marked by a global pandemic caused by a strain of coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19). ...

    • Genetic and molecular functional characterization of variants within TNFSF13B, a positional candidate preeclampsia susceptibility gene on 13q 

      Fenstad, Mona Høysæter; Johnson, Matthew; Roten, Linda Tømmerdal; Aas, Per Arne; Forsmo, Siri; Klepper, Kjetil; East, Christine; Abraham, Lawrence j.; Blangero, John; Brennecke, Shaun P.; Austgulen, Rigmor; Moses, Eric K (Journal article; Peer reviewed, 2010)
      Background: Preeclampsia is a serious pregnancy complication, demonstrating a complex pattern of inheritance. The elucidation of genetic liability to preeclampsia remains a major challenge in obstetric medicine. We have ...

    • Identification and Tracking of Antiviral Drug Combinations 

      Ianevski, Aleksandr; Yao, Rouan; Biza, Svetlana; Zusinaite, Eva; Mannik, Andres; Kivi, Gaily; Planken, Anu; Kurg, Kristiina; Tombak, Eva-Maria; Ustav, Mart Jr; Shtaida, Nastassia; Kulesskiy, Evgeny; Jo, Eunji; Yang, Jaewon; Lysvand, Hilde; Løseth, Kirsti; Oksenych, Valentyn; Aas, Per Arne; Tenson, Tanel; Vitkauskienė, Astra; Windisch, Marc P; Fenstad, Mona H.; Nordbø, Svein Arne; Ustav, Mart; Bjørås, Magnar; Kainov, Denis (Peer reviewed; Journal article, 2020)
      Combination therapies have become a standard for the treatment for HIV and hepatitis C virus (HCV) infections. They are advantageous over monotherapies due to better efficacy, reduced toxicity, as well as the ability to ...

    • Joint changes in RNA, RNA polymerase II, and promoter activity through the cell cycle identify non-coding RNAs involved in proliferation 

      Hegre, Siv Anita; Samdal, Helle; Klima, Antonin; Stovner, Endre Bakken; Nørsett, Kristin Gabestad; Liabakk, Nina-Beate; Olsen, Lene Christin; Chawla, Konika; Aas, Per Arne; Sætrom, Pål (Peer reviewed; Journal article, 2021)
      Proper regulation of the cell cycle is necessary for normal growth and development of all organisms. Conversely, altered cell cycle regulation often underlies proliferative diseases such as cancer. Long non-coding RNAs ...

    • Macromolecular maintenance in human cells : repair of uracil in DNA and methylations in DNA and RNA 

      Aas, Per Arne (Dissertations at the Faculty of Medicine, 0805-7680; 243, Doctoral thesis, 2004)
      In all known organisms, except some viruses, genetic information is contained in the form of DNA. Although genetically relatively stable, DNA is subject to continuous damage from the external- and cellular environment. ...

    • Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells. 

      Zub, Kamila Anna; Sousa, Mirta; Sarno, Antonio; Sharma, Animesh; Demirovic, Aida; Rao, Shalini; Young, Clifford; Aas, Per Arne; Ericsson, Ida; Sundan, Anders; Jensen, Ole Nørregaard; Slupphaug, Geir (Journal article; Peer reviewed, 2015)
      Alkylating agents are widely used chemotherapeutics in the treatment of many cancers, including leukemia, lymphoma, multiple myeloma, sarcoma, lung, breast and ovarian cancer. Melphalan is the most commonly used chemotherapeutic ...

    • NAxtra magnetic nanoparticles for low-cost, efficient isolation of mammalian DNA and RNA 

      Starheim, Eirin Johannessen; Ravlo, Erlend; Schjølberg, Jørn-Ove; Solvang, Vanessa; Wang, Wei; Scrimgeour, Nathan Robert; Manaf, Adeel; Erlandsen, Sten Even; Aas, Per Arne; Hagen, Lars; Sousa, Mirta; Bjørås, Magnar (Peer reviewed; Journal article, 2023)
      A cost-effective, viral nucleic acid (NA) isolation kit based on NAxtra magnetic nanoparticles was developed at the Norwegian University of Science and Technology in response to the shortage of commercial kits for isolation ...

    • OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation 

      Yang, Mingyi; Lin, Xiaolin; Segers, Filip; Suganthan, Rajikala; Hildrestrand, Gunn Annette; Rinholm, Johanne Egge; Aas, Per Arne; Sousa, Mirta; Holm, Sverre; Bolstad, Nils; Warren, David; Berge, Rolf Kristian; Johansen, Rune Forstrøm; Yndestad, Arne; Kristiansen, Elise; Klungland, Arne; Gomez, Luisa Fernanda Luna; Eide, Lars; Halvorsen, Bente; Aukrust, Pål; Bjørås, Magnar (Peer reviewed; Journal article, 2020)
      Oxidation resistance gene 1 (OXR1) protects cells against oxidative stress. We find that male mice with brain-specific isoform A knockout (Oxr1A−/−) develop fatty liver. RNA sequencing of male Oxr1A−/− liver indicates ...

    • Potential Antiviral Options against SARS-CoV-2 Infection. Viruses. 

      Ianevski, Aleksandr; Yao, Rouan; Fenstad, Mona H.; Biza, Svetlana; Zusinaite, Eva; Reisberg, Tuuli; Lysvand, Hilde; Løseth, Kirsti; Landsem, Veslemøy Malm; Fossum, Janne; Erlandsen, Sten Even; Aas, Per Arne; Hagen, Lars; Pettersen, Caroline Hild; Tenson, Tanel; Afset, Jan Egil; Nordbø, Svein Arne; Bjørås, Magnar; Kainov, Denis; Oksenych, Valentyn (Peer reviewed; Journal article, 2020)
      As of June 2020, the number of people infected with severe acute respiratory coronavirus 2 (SARS-CoV-2) continues to skyrocket, with more than 6.7 million cases worldwide. Both the World Health Organization (WHO) and United ...

    • Robust DNA repair in PAXX-deficient mammalian cells 

      Dewan, Alisa Elinsdatter; Xing, Mengtan; Lundbæk, Marie Benner; Gago-Fuentes, Raquel; Beck, Carole; Aas, Per Arne; Liabakk, Nina-Beate; Sæterstad, Siri; Khac Thanh Phong, Chau; Kavli, Bodil Merete; Oksenych, Valentyn (Journal article; Peer reviewed, 2018)
      To ensure genome stability, mammalian cells employ several DNA repair pathways. Nonhomologous DNA end joining (NHEJ) is the DNA repair process that fixes double-strand breaks throughout the cell cycle. NHEJ is involved in ...

    • RPA2 winged-helix domain facilitates UNG-mediated removal of uracil from ssDNA; implications for repair of mutagenic uracil at the replication fork 

      Kavli, Bodil Merete; Iveland, Tobias Solli; Buchinger, Edith; Hagen, Lars; Liabakk, Nina-Beate; Aas, Per Arne; Obermann, Tobias Sebastian; Aachmann, Finn Lillelund; Slupphaug, Geir (Journal article; Peer reviewed, 2021)
      Uracil occurs at replication forks via misincorporation of deoxyuridine monophosphate (dUMP) or via deamination of existing cytosines, which occurs 2-3 orders of magnitude faster in ssDNA than in dsDNA and is 100% miscoding. ...

    • Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is upregulated during DNA replication 

      Diaz, Javier Pena; Hegre, Siv Anita; Anderssen, Endre; Aas, Per Arne; Mjelle, Robin; Gilfillan, Gregor Duncan; Lyle, Robert; Drabløs, Finn; Krokan, Hans Einar; Sætrom, Pål (Journal article; Peer reviewed, 2013)

    • Uracil-DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil 

      Sarno, Antonio; Lundbæk, Marie Benner; Liabakk, Nina-Beate; Aas, Per Arne; Mjelle, Robin; Hagen, Lars; Sousa, Mirta; Krokan, Hans Einar; Kavli, Bodil Merete (Journal article; Peer reviewed, 2019)
      UNG is the major uracil-DNA glycosylase in mammalian cells and is involved in both error-free base excision repair of genomic uracil and mutagenic uracil-processing at the antibody genes. However, the regulation of UNG in ...