• A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling 

      Nilsen, Nadra; Gregory I., Vladimer; Stenvik, Jørgen; Ørning, Mathias Pontus; Zeid-Kilani, Maria Vanessa; Bugge, Marit; Bergstrøm, Bjarte; Conlon, Joseph; Husebye, Harald; Amy, Hise; Fitzgerald, Katherine A.; Espevik, Terje; Lien, Egil (Journal article; Peer reviewed, 2015)
      Toll-like receptors (TLRs) are involved in sensing invading microbes by host innate immunity. TLR2 recognizes bacterial lipoproteins/lipopeptides, and lipopolysaccharide activates TLR4. TLR2 and TLR4 signal via the ...
    • Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation 

      Ørning, Mathias Pontus; Hoem, Kine Samseth; Coron, Abba Elizabeth; Skjåk-Bræk, Gudmund; Mollnes, Tom Eirik; Brekke, Ole Lars; Espevik, Terje; Rokstad, Anne Mari (Journal article; Peer reviewed, 2016)
      The inflammatory potential of 12 types of alginate-based microspheres was assessed in a human whole blood model. The inflammatory potential could be categorized from low to high based on the four main alginate microsphere ...
    • Bacterial secretion systems and regulation of inflammasome activation 

      Ratner, Dmitry; Ørning, Mathias Pontus; Lien, Egil (Journal article, 2017)
      Innate immunity is critical for host defenses against pathogens, but many bacteria display complex ways of interacting with innate immune signaling, as they may both activate and evade certain pathways. Gram‐negative ...
    • RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis 

      Zelic, Matija; Pontarelli, Fabrizio; Woodworth, Lisa; Zhu, Cheng; Mahan, Amy; Ren, Yi; LaMorte, Michael; Gruber, Ross; Keane, Aislinn; Loring, Pequita; Guo, Lilu; Xia, Tai-he; Zhang, Boyao; Ørning, Mathias Pontus; Lien, Egil; Degterev, Alexei; Hammond, Timothy; Ofengeim, Dimitry (Peer reviewed; Journal article, 2021)
    • Streptolysin O Induces the Ubiquitination and Degradation of Pro-IL-1β 

      Hancz, Dora; Westerlund, Elsa; Valfridsson, Christine; Aemero, Getachew Melkamu; Bastiat-Sempe, Benedicte; Ørning, Mathias Pontus; Lien, Egil; Wessels, Michael; Persson, Jenny (Journal article; Peer reviewed, 2019)
      Group A Streptococcus (GAS) is a common and versatile human pathogen causing a variety of diseases. One of the many virulence factors of GAS is the secreted pore-forming cytotoxin streptolysin O (SLO), which has been ...
    • The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation 

      Ratner, Dmitry; Ørning, Mathias Pontus; Proulx, MK; Wang, Donghai; Gavrilin, Mikhail; Wewers, Mark; Alnemri, Emad; Johnson, Peter; Lee, Bettina; Mecsas, Joan; Kayagaki, Nobuhiko; Goguen, JD; Lien, Egil (Journal article; Peer reviewed, 2016)
      Type III secretion systems (T3SS) are central virulence factors for many pathogenic Gram-negative bacteria, and secreted T3SS effectors can block key aspects of host cell signaling. To counter this, innate immune responses ...