Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 3010-3029 av 3415
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T cell subsets in bronchoalveolar lavage fluid in sarcoidosis and other diffuse parenchymal lung diseases
(Doctoral thesis at NTNU;2015:49, Doctoral thesis, 2015)Slimhinnen i luftveiene og lungene er kontinuerlig eksponert for partikler, støv og en stor mengde mikrober fra omgivelsene. Ufarlige mikrober og partikler fjernes med minst mulig betennelsesreaksjon i vevet, slik at ... -
T.M. Gundem og medarbeidere svarer
(Journal article; Peer reviewed, 2020) -
T1 bladder cancer in Norway: treatment and survival
(Peer reviewed; Journal article, 2020)Aim: Evaluation of treatment and survival of pT1 stage (T1) bladder cancer (BC) patients diagnosed with transitional cell carcinoma of the urinary bladder in Norway. Material and methods: According to the Cancer Registry ... -
Tailored microfluidic platforms for advanced neurobiology, neuroengineering and electrophysiology
(Doctoral theses at NTNU;2019:135, Doctoral thesis, 2019) -
TAK1-inhibitors did not reduce disease burden in a Vκ*MYC model of multiple myeloma
(Peer reviewed; Journal article, 2022)Objective Multiple myeloma is a haematological malignancy characterized by proliferation of monoclonal plasma cells in the bone marrow. Development of resistance and minimal residual disease remain challenging in the ... -
Tar pasienter legemidler som forskrevet?
(Master thesis, 2009) -
Targeted correlative light and electron microscopy in the study of host-pathogen interactions
(Doktoravhandlinger ved NTNU;2018:89, Doctoral thesis, 2018)Abstract Tuberculosis (TB) and HIV are the two deadliest infectious diseases in the world today. 1,8 million people died from TB in 2015, 400.000 of which were HIV positive. Drug resistant TB strains are rapidly spreading, ... -
Targeted Next Generation sequencing identified novel gene variants involved in hereditary colorectal cancer
(Master thesis, 2015)cancer (CRC) is one of the most common types of cancer both worldwide and in Norway. Risk factors and mechanisms contributing to the disease are among dietary and lifestyle and somatic and inherited mutations. CRC is ... -
Targeted next-generation sequencing identified novel mismatch repair risk-variants involved in hereditary colorectal cancer
(Master thesis, 2015)Colorectal cancer (CRC) is the third most common malignancy worldwide, with over 1 million new cases annually. Around 30% of cases are believed to be familial with causal genetic alterations. However, fewer than 10% of ... -
Targeted next-generation sequencing of 22 mismatch repair genes identifies Lynch syndrome families
(Peer reviewed; Journal article, 2016)Causative germline mutations in mismatch repair (MMR ) genes can only be identified in ~50% of families with a clinical diagnosis of the inherited colorectal cancer (CRC ) syndrome hereditary nonpolyposis colorectal cancer ... -
Targeted sequencing of genes associated with the mismatch repair pathway in patients with endometrial cancer
(Peer reviewed; Journal article, 2020)Germline variants inactivating the mismatch repair (MMR) genes MLH1, MSH2, MSH6 and PMS2 cause Lynch syndrome that implies an increased cancer risk, where colon and endometrial cancer are the most frequent. Identification ... -
Targeting a therapeutically relevant concentration of alendronate for in vitro studies on osteoblasts
(Peer reviewed; Journal article, 2022)Objective Bisphosphonates like alendronate mainly exert their effects on osteoclasts. However, osteoblasts are also affected, but exposed to a much lower concentration in vivo than the osteoclasts. Given that the effects ... -
Targeting FKBP12 potentiates bone morphogenetic protein signaling in multiple myeloma cells
(Master thesis, 2019)Abstract Background Multiple myeloma (MM) is a malignancy of terminally differentiated plasma cells. Although new treatments approved in the last decades have improved patient outcomes considerably, most patients relapse ... -
Targeting OGG1 arrests cancer cell proliferation by inducing replication stress
(Peer reviewed; Journal article, 2020)Abstract Altered oncogene expression in cancer cells causes loss of redox homeostasis resulting in oxidative DNA damage, e.g. 8-oxoguanine (8-oxoG), repaired by base excision repair (BER). PARP1 coordinates BER and relies ... -
Targeting phosphoglycerate dehydrogenase in multiple myeloma
(Peer reviewed; Journal article, 2021)Background: Multiple myeloma (MM) is a hematological malignancy characterized by the clonal expansion of plasma cells in the bone marrow. To date, this disease is still incurable and novel therapeutic approaches are required. ... -
Targeting Proliferating Cell Nuclear Antigen and Its Protein Interactions Induces Apoptosis in Multiple Myeloma Cells
(Journal article; Peer reviewed, 2013)Multiple myeloma is a hematological cancer that is considered incurable despite advances in treatment strategy during the last decade. Therapies targeting single pathways are unlikely to succeed due to the heterogeneous ... -
Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy
(Journal article, 2019)Receptor tyrosine kinases (RTKs), such as HER2 and/or EGFR are important therapeutic targets in multiple cancer cells. Low and/or short response to targeted therapies are often due to activation of compensatory signaling ... -
Targeting translesion synthesis by inhibiting protein interactions of the DNA sliding clamps
(Doctoral theses at NTNU;2019:354, Doctoral thesis, 2019) -
Tarmfloraen - på helsa løs
(Journal article, 2015) -
Teacher-student approach for lung tumor segmentation from mixed-supervised datasets
(Journal article; Peer reviewed, 2022)Purpose Cancer is among the leading causes of death in the developed world, and lung cancer is the most lethal type. Early detection is crucial for better prognosis, but can be resource intensive to achieve. Automating ...