Browsing Institutt for klinisk og molekylær medisin by Title

Now showing items 993-1012 of 2008

    • Invasive properties of cancer - a treatment target?: In vitro studies in human prostate cancer cell lines 

      Skogseth, Haakon R. (Doktoravhandlinger ved NTNU, 1503-8181; 2006:215, Doctoral thesis, 2007)

    • Investigating optimal β-cell-preserving treatment in latent autoimmune diabetes in adults: Results from a 21-month randomized trial 

      Hals, Ingrid Kathrin; Fleiner, Hanne Fiskvik; Reimers, Nina; Astor, Marianne; Filipsson, Karin; Ma, Zuheng; Grill, Valdemar Erik Robert; Björklund, Anneli (Peer reviewed; Journal article, 2019)
      Aims To compare outcomes of glucagon‐stimulated C‐peptide tests (GSCTs) in people with latent autoimmune diabetes in adults (LADA) after a 21‐month intervention with either insulin or the dipeptidyl peptidase‐4 inhibitor ...

    • Investigating the causal effect of smoking on hay fever and asthma: A Mendelian randomization meta-analysis in the CARTA consortium 

      Skaaby, Tea; Taylor, Amy E; Jacobsen, Rikke K.; Paternoster, Lavinia; Thuesen, Betina H.; Ahluwalia, Tarunveer S.; Larsen, Sofus C.; Zhou, Ang; Wong, Andrew; Gabrielsen, Maiken Elvestad; Bjørngaard, Johan Håkon; Flexeder, Claudia; Männistö, Satu; Hardy, Rebecca; Kuh, Diana; Barry, Sarah J.; Møllehave, Line Tang; Cerqueira, Charlotte; Friedrich, Nele; Bonten, Tobias N.; Noordam, Raymond; Mook-Kanamori, Dennis O.; Taube, Christian; Jessen, Leon E.; McConnachie, Alex; Sattar, Naveed; Upton, Mark N.; McSharry, Charles; Bønnelykke, Klaus; Bisgaard, Hans; Schulz, Holger; Strauch, Konstantin; Meitinger, Thomas; Peters, Annette; Grallert, Harald; Nohr, Ellen A.; Kivimäki, Mika; Kumari, Meena; Völker, Uwe; Nauck, Matthias; Völzke, Henry; Power, Chris; Hyppönen, Elina; Hansen, Torben; Jørgensen, Torben; Pedersen, Oluf; Salomaa, Veikko; Grarup, Niels; Langhammer, Arnulf; Romundstad, Pål Richard; Skorpen, Frank; Kaprio, Jaakko; Munafò, Marcus R.; Linneberg, Allan (Journal article; Peer reviewed, 2017)
      Observational studies on smoking and risk of hay fever and asthma have shown inconsistent results. However, observational studies may be biased by confounding and reverse causation. Mendelian randomization uses genetic ...

    • Investigating the missing data mechanism in quality of life outcomes: a comparison of approaches 

      Fielding, S; Fayers, Peter; Ramsay, CR (Journal article; Peer reviewed, 2009)
      Background: Missing data is classified as missing completely at random (MCAR), missing at random (MAR) or missing not at random (MNAR). Knowing the mechanism is useful in identifying the most appropriate analysis. The ...

    • Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium 

      Taylor, Amy E; Fluharty, Meg; Bjørngaard, Johan Håkon; Gabrielsen, Maiken Elvestad; Skorpen, Frank; Marioni, Riccardo R.; Campbell, A.; Engmann, J; Mirza, Saira Saeed; Loukola, A.; Laatikainen, Tiina; Partonen, Timo; Kaakinen, Marika; Ducci, Francesca; Cavadino, Alana; Husemoen, Lise Lotte N; Ahluwalia, Tarunveer Singh; Jacobsen, Rikke Kart; Skaaby, Tea; Ebstrup, Jeanette Frost; Mortensen, Erik Lykke; Minica, Camelia C; Vink, Jacqueline; Willemsen, Gonneke; Marques-Vidal, Pedro; Dale, Caroline E; Amuzu, Antoinette; Lennon, Lucy; Lahti, J; Palotie, Aarno; Räikkönen, K; Wong, Andrew; Paternoster, Lavinia; Wong, Angelita Pui-Yee; Horwood, L John; Murphy, Michael; Johnstone, Elaine; Kennedy, Martin A; Pausova, Zdenka; Paus, Tomas; Ben-Shlomo, Yoav; Nohr, Ellen A; Kuh, Diana; Kivimaki, Mika; Eriksson, Johan G; Morris, Richard W; Casas, Juan Pablo; Preisig, Martin; Boomsma, Dorret I; Linneberg, Allan; Power, Chris; Hypponen, Elina; Veijola, J; Järvelin, Marjo-Riitta; Korhonen, T.; Tiemeier, H; Kumari, Meena; Porteous, David J.; Hayward, Caroline; Romundstad, Pål Richard; Smith, George Davey; Munafo, Marcus R (Journal article; Peer reviewed, 2014)
      Objectives: To investigate whether associations of smoking with depression and anxiety are likely to be causal, using a Mendelian randomisation approach. Design: Mendelian randomisation meta-analyses using a genetic ...

    • Investigating the Role of PRL-3 and Targeting PHGDH in Multiple Myeloma 

      Elsaadi, Samah (Doctoral theses at NTNU;2020:378, Doctoral thesis, 2020)
      Myelomatose er en hematologisk kreftsykdom som skyldes klonal ekspansjon av plasmaceller som infiltrerer beinmargen. Til tross for fremskritt innen behandlingen av myelomatose, er sykdommen fortsatt uhelbredelig. Artiklene ...

    • Investigation of an outbreak caused by antibiotic susceptible Klebsiella oxytoca in a neonatal intensive care unit in Norway 

      Rønning, Torunn Gresdal; Ås, Christina Gabrielsen; Støen, Ragnhild; Bergh, Kåre; Afset, Jan Egil; Holte, Mari Sagli; Radtke, Andreas (Journal article; Peer reviewed, 2018)
      Abstract Aim Klebsiella spp. have been stated to be the most frequent cause of neonatal intensive care unit (NICU) outbreaks. We report an outbreak of Klebsiella oxytoca in a NICU at a tertiary care hospital in Norway ...

    • Investigation of changes in immunostimulatory properties of clinical Mycobacterium avium strains over time of infection 

      Dietrich, Markus (Master thesis, 2013)

    • Investigation of properties and classification of human transcription factors 

      Bahrami, Shahram (Doctoral theses at NTNU;2016:243, Doctoral thesis, 2016)
      Studier av egenskaper og klassifisering av humane transkripsjonsfaktorer Egenskaper og funksjonen av ulike celler bestemmes gjennom regulering av genuttrykket, og en rekke ulike mekanismer er aktive i den enkelte ...

    • Investigation of the long-term sustainability of changes in appetite after weight loss 

      Nymo, Siren; Coutinho, Silvia dos Santos Ribeiro F; Vestbostad, I.; Kulseng, Bård Eirik; Martins, Catia; Truby, Helen; Rehfeld, Jens Frederik (Journal article; Peer reviewed, 2018)
      Background/Objective Diet-induced weight loss (WL) leads to a compensatory increase in appetite and changes in the plasma concentration of appetite-regulating hormones are likely to play a role. Whether these changes are ...

    • Investigations of immunogenic, allergenic and adjuvant properties of Cry1Ab protein after intragastric exposure in a food allergy model in mice 

      Andreassen, Monica; Bøhn, Thomas; Wikmark, Odd-Gunnar; Bodin, Johanna; Traavik, Terje; Løvik, Martinus; Nygaard, Unni Cecilie (Journal article; Peer reviewed, 2016-05-04)
      Background: In genetically modified (GM) crops there is a risk that the inserted genes may introduce new allergens and/or adjuvants into the food and feed chain. The MON810 maize, expressing the insecticidal Cry1Ab toxin, ...

    • Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice 

      Yang, Hang; Qi, Haili; Ren, Jingli; Cui, Jing; Li, Zhenfeng; Waldum, Helge; Guanglin, Cui (Journal article; Peer reviewed, 2014)
      Nuclear factor-kappaB (NF-κB)/interleukin (IL-6) pathway links chronic inflammation to colitis associated cancer (CAC). In this study, we examined the dynamic temporal changes of the NF-κB/IL-6 pathway during the procession ...

    • Involvement of the ASC-1 complex in processing of methylated DNA and RNA 

      Rabe, Renana (Doctoral theses at NTNU;2018:83, Doctoral thesis, 2018)
      Den grunnleggende informasjon om organismene ligger lagret i DNA, som er en polymer sammensatt av fire ulike nitrogenbaser bundet til en sukkerfosfat ryggrad. Langs DNA-tråden ligger ulike gener, og baserekkefølgen innen ...

    • Iodine status and iodised salt consumption in portuguese school-aged children: The iogeneration study 

      Leite, Joao Costa; Keating, Elisa; Pestana, Diogo; Fernandes, Virginia Cruz; Maia, Maria Luz; Norberto, Sonia; Pinto, Edgar; Moreira-Rosario, Andre; Sintra, Diana; Moreira, Barbara; Costa, Ana; Silva, Sofia; Costa, Vera; Martins, Ines; Mendes, Francisca Castro; Queiros, Pedro; Peixoto, Bruno; Caldas, Jose Carlos; Guerra, Antonio; Fontoura, Manuel; Leal, Sandra; Moreira, Roxana; Carvalho, Irene Palmares; Lima, Rui Matias; Martins, Catia; Delerue-Matos, Cristina; Almeida, Agostinho; Azevedo, Luís; Calhau, Conceição (Journal article; Peer reviewed, 2017)
      The World Health Organization promotes salt iodisation to control iodine deficiency. In Portugal, the use of iodised salt in school canteens has been mandatory since 2013. The present study aimed to evaluate iodine status ...

    • IP-10 differentiates between active and latent tuberculosis irrespective of HIV status and declines during therapy 

      Wergeland, Ida; Pullar, Nadine Durema; Assmus, Jörg; Ueland, Thor; Tonby, Kristian; Feruglio, Siri; Kvale, Dag; Damås, Jan Kristian; Aukrust, Pål; Mollnes, Tom Eirik; Dyrhol-Riise, Anne Ma (Journal article; Peer reviewed, 2015)
      Objectives: Biomarkers for diagnosis and therapy efficacy in tuberculosis (TB) are requested. We have studied biomarkers that may differentiate between active and latent TB infection (LTBI), the influence of HIV infection ...

    • IQ, executive functions and brain findings in very low birth weight (VLBW) children and young adults 

      Sølsnes, Anne Elisabeth (Doctoral thesis at NTNU;2015:333, Doctoral thesis, 2015)
      IQ, eksekutive funksjoner og hjernefunn hos barn og unge voksne født prematurt med veldig lav fødselsvekt Medisinske fremskritt innen nyfødtmedisin har ført til økt overlevelsesrate av prematurt fødte barn de siste to ...

    • Iron oxide nanoparticles induce cytokine secretion in a complement-dependent manner in a human whole blood model 

      Wolf-Grosse, Susann; Rokstad, Anne Mari; Ali, Syed; Lambris, JD; Mollnes, Tom Eirik; Nilsen, Asbjørn Magne; Stenvik, Jørgen (Journal article; Peer reviewed, 2017)
      Abstract: Iron oxide nanoparticles (IONPs) are promising nanomaterials for biomedical applications. However, their inflammatory potential has not been fully established. Here, we used a lepirudin anti-coagulated human whole ...

    • Iron oxide nanoparticles modulate lipopolysaccharide-induced inflammatory responses in primary human monocytes 

      Grosse, Susann; Stenvik, Jørgen; Nilsen, Asbjørn Magne (Journal article; Peer reviewed, 2016)
      Co-stimulation of the immune system to more than one agent concomitantly is very common in real life, and considering the increasing use of engineered nanoparticles and nanomaterials, it is highly relevant to assess the ...

    • Irritable bowel syndrome in Norway 

      Vandvik, Per Olav (Doktoravhandlinger ved NTNU, 1503-8181; 2006:83, Doctoral thesis, 2006)

    • Irritable bowel syndrome in subjects with morbid obesity: Observational studies of patients at outpatient clinics 

      Aasbrenn, Martin (Doctoral theses at NTNU;2018:136, Doctoral thesis, 2018)