Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 993-1012 of 1899
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Learning habits of medical students at the Norwegian University of Science and Technology, and the application of Serious Games in learning dermatovenereology
(Master thesis, 2017)Introduction The interest in so called “Serious Games” (SGs) in education has increased, with several new RCTs in just the last few years, but there is not yet a clear consensus as to the potential benefit of using Serious ... -
Learning the effects of psychotropic drugs during pregnancy using real-world safety data: a paradigm shift toward modern pharmacovigilance
(Peer reviewed; Journal article, 2018)The growing evidence on psychotropic drug safety in pregnancy has been possible thanks to the increasing availability of real-world data, i.e. data not collected in conventional randomised controlled trials. Use of these ... -
Legers erfaringer og vurderinger om hvordan kommunikasjon påvirker pasienters etterlevelse av legemiddelbruk
(Master thesis, 2019)Bakgrunn: Feilbruk av legemidler kan gi unødvendige bivirkninger, nedsatt livskvalitet og dødsfall. WHO rapporterte at 30-50 % av legemidler brukt ved kroniske sykdommer ikke tas som anbefalt. Å ha flere forskrivere har ... -
Legers påvirkning på pasienters etterlevelse av legemiddelbehandling - En spørreundersøkelse
(Master thesis, 2019)Bakgrunn: Lav etterlevelse av legemiddelbehandling er en stor utfordring og det kan føre til store utgifter for samfunnet ved at pasienter ikke opplever bedring av sin sykdomstilstand. Videre kan det føre til økt morbiditet ... -
Legumain is upregulated in acute cardiovascular events and associated with improved outcome – potentially related to anti-inflammatory effects on macrophages
(Peer reviewed; Journal article, 2019)Background and aims We have previously found increased levels of the cysteine protease legumain in plasma and plaques from patients with carotid atherosclerosis. This study further investigated legumain during acute ... -
Lenalidomide versus lenalidomide + dexamethasone prolonged treatment after second-line lenalidomide + dexamethasone induction in multiple myeloma
(Journal article; Peer reviewed, 2018)Lenalidomide (Len) plus dexamethasone (Dex) is approved for the treatment of relapsed or refractory multiple myeloma (RRMM). It is possible that single‐agent Len may be effective as prolonged treatment regimen in RRMM once ... -
Levator ani muscle injury and risk for urinary and fecal incontinence in parous women from a normal population, a cross-sectional study
(Journal article; Peer reviewed, 2019)Aims To study possible associations between levator ani muscle (LAM) injury and urinary incontinence (UI) and fecal incontinence (FI) and possible associations between bladder neck descent (BND), urethral funneling, and ... -
Life after adolescent and adult moderate and severe traumatic brain injury: self-reported executive, emotional, and behavioural function 2-5 years after injury
(Peer reviewed; Journal article, 2015)Survivors of moderate-severe Traumatic Brain Injury (TBI) are at risk for long-term cognitive, emotional, and behaviouralproblems. This prospective cohort study investigated self-reported executive, emotional, and behavioural ... -
Lifestyle behavior among lymphoma survivors after high-dose therapy with autologous hematopoietic stem cell transplantation, assessed by patient-reported outcomes
(Journal article; Peer reviewed, 2019)Introduction: High-dose therapy with autologous stem cell transplantation (HD-ASCT) is associated with an increased risk of late effects. Our aim was to assess lifestyle behavior and factors associated with unhealthy ... -
Limited microstructural and connectivity deficits despite subcortical volume reductions in school-aged children born preterm with very low birth weight.
(Journal article; Peer reviewed, 2015)Preterm birth and very low birth weight (VLBW, ≤ 1500 g) are worldwide problems that burden survivors with lifelong cognitive, psychological, and physical challenges. In this multimodal structural magnetic resonance imaging ... -
Lipid droplets hypertrophy: A crucial determining factor in insulin regulation by adipocytes
(Journal article; Peer reviewed, 2015)Lipid droplets (LDs) hypertrophy in adipocytes is the main cause of energy metabolic system dysfunction, obesity and its afflictions such as T2D. However, the role of adipocytes in linking energy metabolic disorders with ... -
Lipid droplets in hepatitis C virus-infected hepatocytes – exploring the role of TANK-binding kinase 1 and autophagy
(Master thesis, 2020)Hepatisk steatose defineres som opphoping av lipider i lipiddråper i hepatocytter, og er en betydelig årsak til levercirrhose og alvorlig leversykdom. Hepatitt C-virus (HCV) forårsaker steatose, men mekanismene som regulerer ... -
Lipocalin 2 imparts selective pressure on bacterial growth in the bladder and is elevated in women with urinary tract infection
(Journal article; Peer reviewed, 2014)Competition for iron is a critical component of successful bacterial infections, but the underlying in vivo mechanisms are poorly understood. We have previously demonstrated that lipocalin 2 (LCN2) is an innate immunity ... -
Lipocalin 2 is expressed in MLO-Y4 osteocytes and regulated by the peroxisome proliferator activated receptor α agonist fenofibrate.
(Master thesis, 2020)Background: Lipocalin 2 is highly expressed and secreted from osteoblasts in mice. Lately, bone-derived lipocalin 2 has been shown to suppress appetite by binding to the MC4R in hypothalamus. In the present study we wanted ... -
Localization of NG2 immunoreactive neuroglia cells in the rat locus coeruleus and their plasticity in response to stress
(Journal article; Peer reviewed, 2014)The locus coeruleus (LC) nucleus modulates adaptive behavioral responses to stress and dysregulation of LC neuronal activity is implicated in stress-induced mental illnesses. The LC is composed primarily of noradrenergic ... -
Long-term consequences of prematurity: Motor skills, mental health, health-related quality of life and white matter microstructure in young adults born preterm with very low birth weight
(Doctoral theses at NTNU;2017:207, Doctoral thesis, 2017)LANGTIDSKONSEKVENSER AV FOR TIDLIG FØDSEL Motoriske ferdigheter, psykisk helse, livskvalitet og integritet av hjernens hvite substans hos unge voksne født for tidlig med veldig lav fødselsvekt Barn som er født for ... -
Long-term follow-up of mental health, health-related quality of life and associations with motor skills in young adults born preterm with very low birth weight
(Journal article; Peer reviewed, 2016)Background: Being born with very low birth weight(VLBW:≤1500 g) is related to long-term disability and neurodevelopmental problems, possibly affecting mental health and health-related quality of life (HRQoL). However, ... -
Long-Term Incidence of Venous Thromboembolism in Cancer: The Scandinavian Thrombosis and Cancer Cohort
(Journal article; Peer reviewed, 2018)The risk of venous thromboembolism (VTE) in patients who survive the first years after a cancer diagnosis after the acute effects of disease and treatment in comparison to a similar background population has been sparsely ... -
Long-term outcomes in juvenile idiopathic arthritis: 18 years of follow-up in the population-based Nordic Juvenile Idiopathic Arthritis (JIA) cohort.
(Journal article; Peer reviewed, 2019)Objectives This study assessed the long‐term course, remission rate and disease burden in juvenile idiopathic arthritis (JIA) 18 years after disease onset in a population‐based setting from the early biologic era. Methods A ... -
Long-term results after surgical treatment for severe obesity
(Doctoral theses at NTNU;2020:199, Doctoral thesis, 2020)Ny kunnskap om utvikling av alvorlig fedme har erstattet oppfatningen av at av fedme er en individuell selvforskyldt tilstand med en forståelse av at fedme er en kronisk progressiv sykdom med sammensatte årsaksfaktorer. ...