Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 941-960 of 3426
-
Effect of Spinal Cord Burst Stimulation vs Placebo Stimulation on Disability in Patients With Chronic Radicular Pain After Lumbar Spine Surgery: A Randomized Clinical Trial
(Peer reviewed; Journal article, 2022)Importance: The use of spinal cord stimulation for chronic pain after lumbar spine surgery is increasing, yet rigorous evidence of its efficacy is lacking. Objective: To investigate the efficacy of spinal cord burst ... -
Effect of supervised exercise training during pregnancy on neonatal and maternal outcomes among overweight and obese women. Secondary analyses of the ETIP trial: A randomised controlled trial
(Journal article; Peer reviewed, 2017)Background Maternal obesity associates with complications during pregnancy and childbirth. Our aim was to investigate if exercise during pregnancy in overweight/obese women could influence birth weight or other neonatal ... -
The effect of supplementation with low doses of a cod protein hydrolysate on satiety hormones and inflammatory biomarkers in adults with metabolic syndrome: A randomized, double-blind study
(Peer reviewed; Journal article, 2020)Metabolic syndrome (MetS) is characterised by metabolic abnormalities that increase the risk of developing type 2 diabetes mellitus and cardiovascular disease. Altered levels of circulating ghrelin, several adipokines and ... -
Effect of the anticoagulant, storage time and temperature of blood samples on the concentrations of 27 multiplex assayed cytokines - Consequences for defining reference values in healthy humans
(Journal article; Peer reviewed, 2017)Cytokines are potentially useful biomarkers of sepsis and other inflammatory conditions. Many cytokines can be released by leukocytes and platelets after sampling. The sampling and processing techniques are consequently ... -
Effect of Vitamin D3 Supplementation in the First 2 Years of Life on Psychiatric Symptoms at Ages 6 to 8 Years: A Randomized Clinical Trial
(Peer reviewed; Journal article, 2023)Importance Vitamin D is associated with neurodevelopment, but causality, critical windows, and potentials for modification remain unknown. Objective To determine the impact of high-dose (1200 IU) vs standard-dose (400 ... -
Effect on mother and child of eculizumab given before caesarean section in a patient with severe antiphospholipid syndrome
(Journal article; Peer reviewed, 2017)Rationale: Antiphospholipid syndrome (APS) in pregnancy may trigger the life-threatening catastrophic antiphospholipid syndrome (CAPS). Complement activation is implicated in the pathogenesis, and inhibition of complement ... -
Effectiveness of a group-based Diabetes Prevention Education Program (DiPEP) in a population with pre-diabetes: a cluster randomised controlled trial in Nepal
(Journal article; Peer reviewed, 2023)Background Although several lifestyle intervention studies have been conducted in low/middle-income countries, there were no such studies in Nepal. Therefore, a group-based culturally tailored Diabetes Prevention Education ... -
Effectiveness of laxatives in elderly - a cross sectional study in nursing homes
(Journal article; Peer reviewed, 2011)Background Laxatives are efficient drugs, but the effectiveness has been questioned. In nursing homes, the prevalence of constipation is high and laxatives are commonly used drugs. The aims of the study were to assess the ... -
Effects of a Cod Protein Hydrolysate Supplement on Symptoms, Gut Integrity Markers and Fecal Fermentation in Patients with Irritable Bowel Syndrome
(Journal article; Peer reviewed, 2019)Peptides from fish may beneficially affect several metabolic outcomes, including gut health and inflammation. The effect of fish peptides in subjects with irritable bowel syndrome (IBS) has not previously been investigated, ... -
Effects of a fall prevention program in elderly: A pragmatic observational study in two orthopedic departments
(Journal article; Peer reviewed, 2019)Purpose: Falls are a common adverse event experienced by elderly in hospitals. This study assessed the effects of a fall prevention program on the rate of fallers, the patient safety culture, and patient-perceived ... -
Effects of Adrenaline on maternal and fetal fentanyl absorption in epidural analgesia: a randomized trial
(Journal article; Peer reviewed, 2018)Background The combination of low‐dose local anesthesia and lipophilic opioids such as fentanyl is established as a standard solution for labor epidural analgesia. Fentanyl increases efficacy, but may have negative effects ... -
Effects of age and gender on the serum levels of clozapine, olanzapine, risperidone, and quetiapine
(Journal article; Peer reviewed, 2017)Objective To investigate serum concentrations of second-generation antipsychotics in relation to age and gender in a population ranging from 18 to 100 years. Method Results from a routine therapeutic drug monitoring ... -
Effects of antenatal diet and physical activity on maternal and fetal outcomes: Individual patient data meta-analysis and health economic evaluation
(Journal article; Peer reviewed; Research report, 2017)Abstract Background Diet- and physical activity-based interventions in pregnancy have the potential to alter maternal and child outcomes. Objectives To assess whether or not the effects of diet and lifestyle ... -
Effects of APIM-containing peptides on the regulation of the PI3K/Akt and MEK/ERK pathways
(Master thesis, 2013)PI3K/Akt and MEK/ERK pathways are important cellular signaling system which controls many vital cellular processes, including cell survival, proliferation, differentiation and migration. These pathways are often deregulated ... -
Effects of bone morphogenetic proteins, hepatocyte growthfactor and interleukin-21 in multiple myeloma
(Doktoravhandlinger ved NTNU, 1503-8181; 2006:4, Doctoral thesis, 2006)The studies presented in this thesis answer some questions, but also raise new questions which should be explored in future studies. The bone marrow microenvironment is a complex system, and is difficult to study in vitro. ... -
Effects of Budesonide on the Intestinal Epithelium: Studies using IBD patient-derived Colonoids
(Master thesis, 2021)Bakgrunn: Tarmepitelcellene er etter hvert anerkjent som en viktig faktor i sykdomsbildet til inflammatoriske tarmsykdom (IBD). Det tradisjonelle anti-inflammatoriske steroid- legemiddelet budesonid er mye brukt i behandling ... -
Effects of cPLA2a inhibition in the MDA-MB-468 cell model system for basal-like breast cancer and/or triple negative breast cancer
(Master thesis, 2016)Basal-like breast cancer (BLBC) is a highly aggressive breast cancer sub-type and represents ~15% of all breast cancers. BLBC are often associated with early age of onset, early relapse and poor overall survival in contrast ... -
Effects of cPLA2α inhibition in the MDAMB-468 cell model system for basal-like breast cancer and/or triple negative breast cancer
(Master thesis, 2016)Basal-like breast cancer (BLBC) is a highly aggressive breast cancer sub-type and represents ~15% of all breast cancers. BLBC are often associated with early age of onset, early relapse and poor overall survival in contrast ... -
Effects of current parenteral nutrition treatment on health-related quality of life, physical function, nutritional status, survival and adverse events exclusively in patients with advanced cancer: A systematic literature review
(Journal article; Peer reviewed, 2019)Background: The aim was to evaluate the effects of current parenteral nutrition (PN) treatment on clinical outcomes in patients with advanced cancer. Methods: This review was conducted according to the PRISMA guidelines ... -
Effects of doxorubicin on cell death and the transcriptome in human AC16 cardiomyocytes
(Master thesis, 2022)Bakgrunn: Kreft og hjarte- og karsjukdom er leiande dødsårsaker i verda. Doxorubicin er mykje nytta som cellegift i kreftbehandling, men utvikling av kardiotoksisitet avgrensar bruken. Faktorar som bidreg til doxorubicin-indusert ...