Blar i Institutt for klinisk og molekylær medisin på tittel
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Eculizumab treatment during pregnancy does not affect the complement system activity of the newborn
(Journal article; Peer reviewed, 2015)Eculizumab is a humanized IgG2/4 chimeric anti-complement C5 antibody used to treat patients with paroxysmal nocturnal hemoglobinuria (PNH) or atypical hemolytic uremic syndrome. The aim of this study was to evaluate whether ... -
Eculizumab-C5 complexes express a C5a neoepitope in vivo: Consequences for interpretation of patient complement analyses
(Journal article; Peer reviewed, 2017)The complement system has obtained renewed clinical focus due to increasing number of patients treated with eculizumab, a monoclonal antibody inhibiting cleavage of C5 into C5a and C5b. The FDA approved indications are ... -
Editorial: Protection and healing in the digestive system and other tissues: Novel factors, mechanisms, and pharmaceutical targets
(Peer reviewed; Journal article, 2022) -
Edmonton Frail Scale predicts mortality in older patients with cancer undergoing radiotherapy-A prospective observational study
(Peer reviewed; Journal article, 2023)Background: Several screening tools are developed to identify frailty in the increasing number of older patients with cancer. Edmonton Frail Scale (EFS) performs well in geriatric settings but is less studied in oncology. ... -
Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: A double-blind cross-over trial
(Journal article; Peer reviewed, 2018)The increased prevalence of lifestyle diseases, such as the metabolic syndrome and type 2 diabetes mellitus (T2DM), calls for more knowledge on dietary treatments targeting the specific metabolic pathways involved in these ... -
Effect of a ketogenic diet on pain and quality of life in patients with lipedema: The LIPODIET pilot study
(Peer reviewed; Journal article, 2021)Background Lipedema is an underdiagnosed condition in women, characterized by a symmetrical increase in subcutaneous adipose tissue (SAT) in the lower extremities, sparing the trunk. The lipedema SAT has been found to be ... -
Effect of a multifaceted educational program for care staff concerning fecal incontinence in nursing home patients: Study protocol of a cluster randomized controlled trial
(Journal article; Peer reviewed, 2015)Background Fecal incontinence has a high prevalence in the older population, which cannot be explained by comorbidity or the anatomical or psychological changes of aging alone. Fecal incontinence leads to a high economic ... -
Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-ST-elevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial
(Journal article; Peer reviewed, 2016)Aims Interleukin-6 (IL-6) contributes to atherosclerotic plaque destabilization and is involved in myocardial injury during ischaemia–reperfusion. Interleukin-6 is therefore a potential therapeutic target in myocardial ... -
Effect of acoustic cluster therapy (ACT®) combined with chemotherapy in a patient-derived xenograft mouse model of pancreatic cancer
(Peer reviewed; Journal article, 2022)Pancreatic ductal adenocarcinomas respond poorly to chemotherapy, in part due to the dense tumor stroma that hinders drug delivery. Ultrasound (US) in combination with microbubbles has previously shown promise as a means ... -
Effect of Acoustic Radiation Force on the Distribution of Nanoparticles in Solid Tumors.
(Peer reviewed; Journal article, 2020)Acoustic radiation force (ARF) might improve the distribution of nanoparticles (NPs) in tumors. To study this, tumors growing subcutaneously in mice were exposed to focused ultrasound (FUS) either 15 min or 4 h after the ... -
Effect of Aerobic Exercise Intensity on Energy Expenditure and Weight Loss in Severe Obesity-A Randomized Controlled Trial
(Peer reviewed; Journal article, 2021)Objective This study aimed to compare the effects of two aerobic exercise programs of different intensities on energy expenditure. Methods This was a single‐center randomized controlled trial of patients with severe obesity ... -
Effect of DHA on growth of two human colon cancer cell lines - the role of ER stress and unfolded protein response
(Master thesis, 2014)Docosahexaenoic acid (DHA; 22:6n-3) is an essential omega-3 polyunsaturated fatty acid important to human health. DHA has been shown to have anticancer properties by reducing cancer cell proliferation, inducing apoptosis ... -
Effect of Disulfiram and Copper Plus Chemotherapy vs Chemotherapy Alone on Survival in Patients with Recurrent Glioblastoma: A Randomized Clinical Trial
(Peer reviewed; Journal article, 2023)Importance Disulfiram has demonstrated broad antitumoral effect in several preclinical studies. One of the proposed indications is for the treatment of glioblastoma. Objective To evaluate the efficacy and safety of ... -
The effect of glucagon on local subcutaneous blood flow in non-diabetic volunteers; a proof-of-concept study
(Peer reviewed; Journal article, 2022)Introduction Glucagon and insulin are the two most important hormones for glucose metabolism and have been incorporated in the dual-hormonal artificial pancreas, a device for automated glucose regulation for people with ... -
Effect of High-Dose vs Standard-Dose Vitamin D Supplementation on Neurodevelopment of Healthy Term Infants: A Randomized Clinical Trial
(Peer reviewed; Journal article, 2021)Importance Vitamin D may be important for neurodevelopment. The optimal daily dose of vitamin D for early brain development is not known. Objectives To test whether a higher (1200 IU) vs standard (400 IU) dose of ... -
Effect of intranasal oxytocin on alcohol withdrawal syndrome: A randomized placebo-controlled double-blind clinical trial
(Peer reviewed; Journal article, 2019)Background In a pilot study, intranasal oxytocin was demonstrated to reduce the benzodiazepine dose needed to relieve withdrawal symptoms during alcohol detoxification. The aim of the present study was to compare the ... -
The effect of intranasal oxytocin on processing emotional stimuli during alcohol withdrawal: A randomized placebo-controlled double-blind clinical trial
(Peer reviewed; Journal article, 2022)Alcohol dependence is associated with difficulties in processing emotional stimuli, which can lead to interpersonal problems. The neuropeptide oxytocin has been shown to modulate the processing of emotional stimuli, however, ... -
Effect of photodynamic therapy using hexyl aminolevulinate and Amphinex – in vitro and in vivo studies
(Master thesis, 2011)Photodynamic therapy (PDT) is based on administration of photosensitizers (PS) which preferentially accumulates in tumor cells, followed by exposure of light that excites PS molecules and generation of singlet oxygen or ... -
Effect of physical exercise on muscle mass and strength in cancer patients during treatment : A systematic review
(Journal article; Peer reviewed, 2013)Cancer treatment and its side effects may cause muscle wasting. Physical exercise has the potential to increase muscle mass and strength and to improve physical function in cancer patients undergoing treatment. A systematic ...