Blar i Institutt for klinisk og molekylær medisin på tittel

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    • Dissecting the roles of ASPM and Clusterin in gastric oxyntic mucosa - from immature stem cells to metaplastic chief cells 

      Vange, Pål (Doctoral theses at NTNU;2018:289, Doctoral thesis, 2018)
      Gastric cancer is the third most common cause of cancer-related mortality worldwide. Increased understanding of initiation of gastric carcinogenesis and development of tools that enable early diagnosis are of critical ...

    • Distance, accessibility and costs. Decision-making During Childbirth in Rural Sierra Leone: a Qualitative Study 

      Treacy, Laura; Bolkan, Håkon Angell; Sagbakken, Mette (Journal article; Peer reviewed, 2018)
      Sierra Leone has one of the highest maternal mortality ratios in the world. Efforts to reduce maternal mortality have included initiatives to encourage more women to deliver at health facilities. Despite the introduction ...

    • Distinct First Trimester Cytokine Profiles for Gestational Hypertension and Preeclampsia 

      Tangerås, Line Haugstad; Austdal, Marie; Skråstad, Ragnhild; Salvesen, Kjell Å; Austgulen, Rigmor; Bathen, Tone Frost; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2015)
      Objective—Gestational hypertension and preeclampsia involve dysregulated maternal inflammatory responses to pregnancy, but whether such responses differ between the disorders has not been determined. We aimed to investigate ...

    • Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases. 

      de Jesus, Adriana Almeida; Hou, Yangfeng; Brooks, Stephen; Malle, Louise; Biancotto, Angelique; Huang, Yan; Calvo, Katherine R.; Marrero, Bernadette; Moir, Susan; Oler, Andrew J.; Deng, Zuoming; Sanchez, Gina A. Montealegre; Ahmed, Amina; Allenspach, Eric; Srabshahi, Bita; Behrens, Edward M.; Benseler, Susanne; Berzrodnik, Liliana; Bout-Tabaku, Sharon; Brescia, AnneMarie; Brown, Diane; Burnham, Jon M.; Caldirola, Maria Soledad; Carrasco, Ruy; Chan, Alice; Cimaz, Rolando; Dancey, Paul; Dare, Jason; DeGuzman, Marietta; Dimitriades, Victoria; Ferguson, Ian; Ferguson, Polly J.; Finn, Laura; Gattorno, Marco; Grom, Alexei; Hanson, Eric P.; Hashkes, Philip; Hedrich, Christian M.; Herzog, Ronit; Horneff, Gerd; Jerath, Rita; Kessler, Elizabeth; Kim, Hanna; Kingsbury, Daniel J.; Laxer, Ronald M; Lee, Pui Y.; Lee-Kirsch, Min Ae; Lewandowski, Laura; Li, Suzanne; Lilleby, Vibke; Mammadova, Vafa; Moorthy, Lakshmi N.; Nasrullayeva, Gulnara M.; O'Neill, Kathleen; Onel, Karen; Ozen, Seza; Pan, Nancy; Pillet, Pascal; Piotto, Daniela G. P.; Punaro, Marilynn G.; Reiff, Andreas; Reinhardt, Adam L.; Rider, Lisa G.; Rivas-Chacon, Rafael; Ronis, Tova; Rosen-Wolff, Angela; Roth, Johannes; Ruth, Natasha Mckerran; Rygg, Marite; Schmeling, Heinrike; Schulert, Grant; Scott, Christiaan; Seminario, Gisella; Schulman, Andrew; Sivaraman, Vidya; Son, Mary Beth; Stepanovskiy, Yuriy; Stringer, Elizabeth; Taber, Sara; Terreri, Maria Teresa; Tifft, Cynthia J; Torgerson, Troy R.; Tosi, Laura; Royen-Kerkhof, Annet Van; Muskardin, Theresa Wampler; Canna, Scott W.; Goldbach-Mansky, Raphaela (Peer reviewed; Journal article, 2020)
      BACKGROUND. Undifferentiated systemic autoinflammatory diseases (USAIDs) present diagnostic and therapeutic challenges. Chronic interferon (IFN) signaling and cytokine dysregulation may identify diseases with available ...

    • Disulfiram repurposing combined with nutritional copper supplement as add-on to chemotherapy in recurrent glioblastoma (DIRECT): Study protocol for a randomized controlled trial 

      Jakola, Asgeir S.; Werlenius, Katja; Mudaisi, Munila; Hylin, Sofia; Kinhult, Sara; bartek, Jiri Jr.; Salvesen, Øyvind; Carlsen, Sven Magnus; Strandeus, Michael; Lindskog, Magnus; Lofgren, David; Rydenhaug, Bertil; Carstam, Louise; Gulati, Sasha; Solheim, Ole; Bartek, Jiri; Solheim, Tora Skeidsvoll (Journal article; Peer reviewed, 2018)
      Background: Disulfiram (DSF) is a well-tolerated, inexpensive, generic drug that has been in use to treat alcoholism since the 1950s. There is now independent preclinical data that supports DSF as an anticancer agent, and ...

    • Divalent ligand-monovalent molecule binding 

      Janssen, Mathijs Adriaan; Stenmark, Harald; Carlson, Andreas (Peer reviewed; Journal article, 2021)
      Simultaneous binding of a divalent ligand to two identical monovalent molecules is a widespread phenomenon in biology and chemistry. Here, we describe how two such monovalent molecules B bind to a divalent ligand AA to ...

    • Divergent Regulation of Decidual Oxidative-Stress Response by NRF2 and KEAP1 in Preeclampsia with and without Fetal Growth Restriction 

      Mundal, Siv Boon; Rakner, Johanne Johnsen; Silva, Gabriela; Gierman, Lobke; Austdal, Marie; Basnet, Purusotam; Elschot, Mattijs; Bakke, Siril Skaret; Ostrop, Jenny; Thomsen, Liv Cecilie Vestrheim; Moses, Eric; Acharya, Ganesh; Bjørge, Line; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2022)
      Utero-placental development in pregnancy depends on direct maternal–fetal interaction in the uterine wall decidua. Abnormal uterine vascular remodeling preceding placental oxidative stress and placental dysfunction are ...

    • Diverse functions of DNA glycosylases processing oxidative base lesions in brain 

      Scheffler, Katja; Bjørås, Karine Øian; Bjørås, Magnar (Peer reviewed; Journal article, 2019)
      Endogenous and exogenous oxidative agents continuously damage genomic DNA, with the brain being particularly vulnerable. Thus, preserving genomic integrity is key for brain health and neuronal function. Accumulation of DNA ...

    • Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain 

      Dgama, Percival Paul Menino; Qiu, Tao; Cosacak, Mehmet Ilyas; Rayamajhi, Dheeraj; Konac, Ahsen; Hansen, Jan Niklas; Ringers, Christa; Acuna Hinrichsen, Francisca Daniela; Hui, Subhra; Olstad, Emilie Willoch; Chong, Yan Ling; Lim, Charlton Kang An; Gupta, Astha; Ng, Chee Peng; Nilges, Benedikt S.; Kashikar, Nachiket; Wachten, Dagmar; Liebl, David; Kikuchi, Kazu; Kizil, Caghan; Yaksi, Emre; Roy, Sudipto; Jurisch-Yaksi, Nathalie (Peer reviewed; Journal article, 2021)
      Motile cilia defects impair cerebrospinal fluid (CSF) flow and can cause brain and spine disorders. The development of ciliated cells, their impact on CSF flow, and their function in brain and axial morphogenesis are not ...

    • Diversity in changes of HRQoL over a one-year period after radiotherapy in Norwegian breast cancer survivors – results of cluster analyses 

      Lazarewicz, Magdalena Anna; Wlodarczyk, Dorota; Lundgren, Steinar; Reidunsdatter, Randi Johansen (Journal article; Peer reviewed, 2019)
      Purpose The diversity in long-term changes in health-related quality of life (HRQoL) among breast cancer (BC) survivors is poorly understood. The aim of this study was to identify clusters of trajectories (subgroups of ...

    • Divulging a Pleiotropic Role of Succinate Receptor SUCNR1 in Renal Cell Carcinoma Microenvironment 

      Najm, Rania; Hachim, Mahmood Yaseen; Kandasamy, Richard Kumaran (Peer reviewed; Journal article, 2022)
      The succinate receptor, SUCNR1, has been attributed to tumor progression, metastasis, and immune response modulation upon its activation via the oncometabolite succinate. Nonetheless, little is known about the prognostic ...

    • DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates 

      Rasmussen, Erik; Vågbø, Cathrine Broberg; Münch, Daniel; Krokan, Hans Einar; Klungland, Arne; Amdam, Gro Vang; Dahl, John Arne (Journal article; Peer reviewed, 2016)
      Well-known epigenetic DNA modifications in mammals include the addition of a methyl group and a hydroxyl group to cytosine, resulting in 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) respectively. In contrast, ...

    • DNA damage tolerance in human cells mediated by the APIM-containing proteins REV3L, HLTF, and SHPRH 

      Seelinger, Mareike (Doctoral theses at NTNU;2020:108, Doctoral thesis, 2020)

    • DNA excision repair of uracil and 5-fluorouracil in human cancercell lines 

      Visnes, Torkild (Doktoravhandlinger ved NTNU, 1503-8181; Doktoravhandlinger ved NTNU, 2009:260, Doctoral thesis, 2009)
      DNA er et tilsynelatende stabilt molekyl, som overføres så å si uten endringer fra unnfangelse til alderdom og fra generasjon til generasjon. Men arvestoffet vårt er ikke så uforanderlig som det kan se ut som. DNA kan ...

    • DNA glycosylase Neil2 contributes to genomic responses in the spleen during clinical prion disease 

      Scheffler, Katja; Jalland, Clara Maria Osnes; Benestad, Sylvie L.; Moldal, Torfinn; Ersdal, Cecilie; Gunnes, Gjermund; Suganthan, Rajikala; Bjørås, Magnar; Tranulis, Michael A. (Peer reviewed; Journal article, 2020)
      The DNA glycosylase Neil2 is a member of the base excision repair (BER) family of enzymes, which are important for repair of oxidative DNA damage. Specifically, Neil2 participates in repair of oxidized bases in single-stranded ...

    • DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development 

      Quiles-Jiménez, Ana M T; Gregersen, Ida; Segers, Filip; Skarpengland, Tonje; Kroustallaki, Pinelopi; Yang, Kuan; Kong, Xiang Yi; Lauritzen, Knut Husø; Olsen, Maria Belland; Karlsen, Tom Rune; Nyman, Tuula Anneli; Sagen, Ellen Lund; Bjerkeli, Vigdis; Suganthan, Rajikala; Nygård, Ståle; Scheffler, Katja; Prins, Jurriën; Van der Veer, Eric; Øgaard, Jonas; Fløisand, Yngvar; Jørgensen, Helle F.; Holven, Kirsten Bjørklund; Biessen, Erik A.L.; Nilsen, Hilde; Dahl, Tuva Børresdatter; Holm, Sverre; Bennett, Martin R.; Aukrust, Pål; Bjørås, Magnar; Halvorsen, Bente (Peer reviewed; Journal article, 2021)
      Background and aims Atherogenesis involves a complex interaction between immune cells and lipids, processes greatly influenced by the vascular smooth muscle cell (VSMC) phenotype. The DNA glycosylase NEIL3 has previously ...

    • DNA hypermethylation associated with upregulated gene expression in prostate cancer demonstrates the diversity of epigenetic regulation 

      Rauluseviciute, Ieva; Drabløs, Finn; Rye, Morten Beck (Journal article; Peer reviewed, 2020)
      Background Prostate cancer (PCa) has the highest incidence rates of cancers in men in western countries. Unlike several other types of cancer, PCa has few genetic drivers, which has led researchers to look for additional ...

    • DNA methylation changes in response to neoadjuvant chemotherapy are associated with breast cancer survival 

      Pedersen, Christine Aaserød; Cao, Maria Dung; Fleischer, Thomas; Rye, Morten Beck; Knappskog, Stian; Eikesdal, Hans Petter; Lønning, Per Eystein; Tost, Jörg; Kristensen, Vessela N.; Tessem, May-Britt; Giskeødegård, Guro F.; Bathen, Tone Frost (Peer reviewed; Journal article, 2022)
      Background Locally advanced breast cancer is a heterogeneous disease with respect to response to neoadjuvant chemotherapy (NACT) and survival. It is currently not possible to accurately predict who will benefit from the ...

    • DNA methylation data by sequencing: experimental approaches and recommendations for tools and pipelines for data analysis 

      Rauluseviciute, Ieva; Drabløs, Finn; Rye, Morten Beck (Journal article; Peer reviewed, 2019)
      Sequencing technologies have changed not only our approaches to classical genetics, but also the field of epigenetics. Specific methods allow scientists to identify novel genome-wide epigenetic patterns of DNA methylation ...

    • DNA methylation-based age acceleration observed in IDH wild-type glioblastoma is associated with better outcome-including in elderly patients 

      Bady, Pierre; Marosi, Christine; Weller, Michael; Grønberg, Bjørn Henning; Schultz, Henrik; Taphoorn, Martin J B; Gijtenbeek, Johanna M M; van den Bent, Martin J.; von Deimling, Andreas; Stupp, Roger; Malmström, Annika; Hegi, Monika E. (Peer reviewed; Journal article, 2022)
      Elderly patients represent a growing proportion of individuals with glioblastoma, who however, are often excluded from clinical trials owing to poor expected prognosis. We aimed at identifying age-related molecular differences ...