Blar i Institutt for klinisk og molekylær medisin på tittel
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Determination of anti-anisakis simplex antibodies and relationship with αβ and γδ lymphocyte subpopulations in patients with Crohn's Disease
(Journal article; Peer reviewed, 2017)Background The etiology of Crohn’s disease (CD) is still unknown although new theories are based on defects in innate immunity. We have previously shown a decrease in γδ T cells in CD patients. Previous studies have shown ... -
Developing quantitative imaging of Akt activation in tissue sections
(Master thesis, 2012)The PI3K/mTOR pathway regulates fundamental cellular processes such as proliferation, growth, metabolism and autophagy. PI3K signalling is often constitutively activated in cancer cells and tumours. Chemical inhibitors ... -
Development and aging of cortical thickness correspond to genetic organization patterns
(Journal article; Peer reviewed, 2015)There is a growing realization that early life influences have lasting impact on brain function and structure. Recent research has demon- strated that genetic relationships in adults can be used to parcellate the cortex ... -
Development and course of chronic pain over 4 years in the general population: The HUNT pain study
(Journal article; Peer reviewed, 2018)Background Epidemiological studies of chronic pain frequently report high prevalence estimates. However, there is little information about the development and natural course of chronic pain. Methods We followed a ... -
Development and course of chronic widespread pain: the role of time and pain characteristics (the HUNT pain study)
(Journal article; Peer reviewed, 2019)Chronic widespread pain (CWP) is common and associated with loss of functioning and health. Subjects with chronic nonwidespread pain (CnWP) are at increased risk of developing CWP, but few studies have described the nature ... -
Development and Optimization of a Screen for Determining Reduced Sensitivity to the Antimicrobial Peptide Betatide in 4,000 Non-Essential Single Gene Knockouts of Escherichia coli
(Master thesis, 2022)Abstract will be available on 2075-07-01 -
Development and Validation of a Deep Learning Method to Predict Cerebral Palsy From Spontaneous Movements in Infants at High Risk
(Peer reviewed; Journal article, 2022)Importance Early identification of cerebral palsy (CP) is important for early intervention, yet expert-based assessments do not permit widespread use, and conventional machine learning alternatives lack validity. Objective ... -
The development and validation of a high-capacity serological assay for celiac disease
(Peer reviewed; Journal article, 2022)Background The aim of the present study was to develop and clinically validate a high-throughput assay for serum IgA and IgG antibodies against transglutaminase-2 (TG2) and to determine appropriate assay cut-offs for ... -
Development and validation of a prediction model for incident hand osteoarthritis in the HUNT study
(Peer reviewed; Journal article, 2020)Objective To develop and externally validate prediction models for incident hand osteoarthritis (OA) in a large population-based cohort of middle aged and older men and women. Design We included 17,153 men and 18,682 ... -
Development and Validation of the Both Hands Assessment for Children With Bilateral Cerebral Palsy
(Journal article; Peer reviewed, 2017)Aims: To develop a hand function test for children with bilateral cerebral palsy (CP) measuring bimanual performance, including quantification of possible asymmetry of hand use. Method: The Both Hands Assessment (BoHA) ... -
Development of a Biosensor Concept to Detect the Production of Cluster-Specific Secondary Metabolites
(Journal article; Peer reviewed, 2017)Genome mining of actinomycete bacteria aims at the discovery of novel bioactive secondary metabolites that can be developed into drugs. A new repressor-based biosensor to detect activated secondary metabolite biosynthesis ... -
Development of a CRISPR/Cas9 knockout-complementation system for application in HIV host dependency factor analysis.
(Master thesis, 2020)Over the past two decades, substantial research has produced a vast array of HIV treatments. However, the rapid mutation rate of the virus has lead to high drug resistance against the treatments. To combat the rapid mutations ... -
Development of a deep inspiration breath-hold system for radiotherapy utilizing a laser distance measurer
(Journal article; Peer reviewed, 2017)Deep inspiration breath‐hold (DIBH) is a technique for treating left‐sided breast cancer (LSBC). In modern radiotherapy, one of the main aims is to exclude the heart from the beam aperture with an individualized beam design ... -
Development of a rapid and simplified protocol for direct bacterial identification from positive blood cultures by using matrix assisted laser desorption ionization time-of- flight mass spectrometry.
(Peer reviewed; Journal article, 2015)Background Bloodstream infections represent serious conditions carrying a high mortality and morbidity rate. Rapid identification of microorganisms and prompt institution of adequate antimicrobial therapy is of utmost ... -
Development of a Spectral Library for the Discovery of Altered Genomic Events in Mycobacterium avium Associated With Virulence Using Mass Spectrometry-Based Proteogenomic Analysis
(Peer reviewed; Journal article, 2023)Mycobacterium avium is one of the prominent disease-causing bacteria in humans. It causes lymphadenitis, chronic and extrapulmonary, and disseminated infections in adults, children, and immunocompromised patients. M. avium ... -
Development of a tailored microfluidic platform with improved electrical signal detection for in vitro studies of neural networks and neural network pathology
(Master thesis, 2020)Menneskets nervesystem utgjør verdens mest avanserte evolusjonære maskineri. Gjennom dets høyst intrikate arkitektur og beregningsevner kontrollerer det oppgaver så funksjonelt forskjellige som muskelbevegelser og lagring ... -
Development of an Effective Method for Studying Pancreatic Cancer: Formation of Spheroids in 3D Culture
(Master thesis, 2021)Pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDAC), is a highly fatal malignancy and the tumor microenvironment plays an important role in its tumorigenesis. The improvement of treatment methods has ... -
Development of an improved pathway analysis - The FunHop story
(Doctoral theses at NTNU;2022:212, Doctoral thesis, 2022)Norsk sammendrag Arbeidet som presenteres i denne avhandlingen omhandler metabolisme i prostatakreft, hovedsakelig i form av bruk og forbedring av analyse av biologiske spor. En stor del av oppgaven handler om utvikling ... -
Development of bimanual performance in young children with cerebral palsy
(Journal article; Peer reviewed, 2018)Aim To describe the development of bimanual performance among young children with unilateral or bilateral cerebral palsy (CP). Method A population‐based sample of 102 children (53 males, 49 females), median age 28.5 ... -
Development of EirV3 - a computer-based tool for patient reported outcome measures in cancer
(Journal article; Peer reviewed, 2017)Purpose Immediate transfer of patient-reported outcome measures (PROMs) for use in medical consultations is facilitated by electronic assessments. We aimed to describe the rationale and development of Eir version 3 (EirV3), ...