Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 749-768 of 2008
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Genetic Variation/Evolution and Differential Host Responses Resulting from In-Patient Adaptation of Mycobacterium avium
(Journal article; Peer reviewed, 2019)Members of the Mycobacterium avium complex (MAC) are characterized as nontuberculosis mycobacteria and are pathogenic mainly in immunocompromised individuals. MAC strains show a wide genetic variability, and there is growing ... -
Genmodifisert maislinje MON810. Uttalelse fra Faggruppe for genmodifiserte organismer i Vitenskapskomiteen for mattrygghet 09.11.07
(VKM Report;, Research report, 2007) -
Genome-wide analysis of the oxyntic proliferative isthmus zone reveals ASPM as a possible gastric stem/progenitor cell marker overexpressed in cancer.
(Journal article; Peer reviewed, 2015)The oxyntic proliferative isthmus zone contains the main stem/progenitor cells that provide for physiological renewal of the distinct mature cell lineages in the oxyntic epithelium of the stomach. These cells are also ... -
Genome-wide association scan identifies a risk locus for preeclampsia on 2q14, near the inhibin, beta B gene
(Journal article; Peer reviewed, 2012)Elucidating the genetic architecture of preeclampsia is a major goal in obstetric medicine. We have performed a genome-wide association study (GWAS) for preeclampsia in unrelated Australian individuals of Caucasian ancestry ... -
Genome-wide association study identifies multiple susceptibility loci for multiple myeloma
(Peer reviewed; Journal article, 2016)Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power ... -
Genome-wide microRNA screening in Nile tilapia reveals pervasive isomiRs’ transcription, sex-biased arm switching and increasing complexity of expression throughout development
(Journal article; Peer reviewed, 2018)MicroRNAs (miRNAs) are key regulators of gene expression in multicellular organisms. The elucidation of miRNA function and evolution depends on the identification and characterization of miRNA repertoire of strategic ... -
Genome-wide Phenotypic Profiling Identifies and Categorizes Genes Required for Mycobacterial Low Iron Fitness
(Journal article; Peer reviewed, 2019)Iron is vital for nearly all living organisms, but during infection, not readily available to pathogens. Infectious bacteria therefore depend on specialized mechanisms to survive when iron is limited. These mechanisms make ... -
Genome-Wide Profile of Pleural Mesothelioma versus Parietal and Visceral Pleura: The emerging Gene Portrait of the Mesothelioma Phenotype
(Journal article; Peer reviewed, 2009) -
Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation
(Journal article; Peer reviewed, 2017)Sertoli cells have dual roles during the cells’ lifetime. In the juvenile mammal, Sertoli cells proliferate and create the structure of the testis, and during puberty they cease to proliferate and take on the adult role ... -
Genotoxic assessment of the metabolite M-11 of mepanipyrim, the active ingredient in the plant protection product FRUPICA SC. Opinion of the Panel on Plant Protection Products of the Norwegian Scientific Committee for Food Safety
(VKM Report;, Research report, 2015)The VKM Panel for plant protection products considered Frupica SC in a meeting on 25.11.2010, and found the active ingredient problematic with regard to carcinogenic effects and possible genotoxicity. M11 is a metabolite ... -
Geriatric assessment is superior to oncologists’ clinical judgement in identifying frailty
(Journal article; Peer reviewed, 2017)Background: Frailty is a syndrome associated with increased vulnerability and an important predictor of outcomes in older cancer patients. Systematic assessments to identify frailty are seldom applied, and oncologists’ ... -
Gestational Diabetes in Europe
(Master thesis, 2009) -
Gestational weight gain outside the Institute of Medicine recommendations and adverse pregnancy outcomes: analysis using individual participant data from randomised trials
(Journal article; Peer reviewed, 2019)Background:High Body Mass Index (BMI) and gestational weight gain (GWG) affect an increasing number ofpregnancies. The Institute of Medicine (IOM) has issued recommendations on the optimal GWG for womenaccording to their ... -
Global Assessment of Mycobacterium avium subsp. hominissuis Genetic Requirement for Growth and Virulence
(Journal article; Peer reviewed, 2019)Nontuberculous mycobacterial infections caused by the opportunistic pathogen Mycobacterium avium subsp. hominissuis (MAH) are currently receiving renewed attention due to increased incidence combined with difficult treatment. ... -
Glomerular abundance of complement proteins characterized by proteomic analysis of laser-captured microdissected glomeruli associates with progressive disease in IgA nephropathy
(Journal article; Peer reviewed, 2017)Background The clinical course of IgA nephropathy (IgAN) is variable and complement activation may predict prognosis. The present study investigated whether glomerular abundance of complement proteins associates with ... -
Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer
(Journal article; Peer reviewed, 2019)Introduction Glutaminase inhibitors target cancer cells by blocking the conversion of glutamine to glutamate, thereby potentially interfering with anaplerosis and synthesis of amino acids and glutathione. The drug CB-839 ... -
gp130 in late osteoblasts and osteocytes is required for PTH-induced osteoblast differentiation
(Journal article; Peer reviewed, 2014)Parathyroid hormone (PTH) treatment stimulates osteoblast differentiation and bone formation, and is the only currently approved anabolic therapy for osteoporosis. In cells of the osteoblast lineage, PTH also stimulates ... -
Granulocyte and monocyte CD11b expression during plasma separation is dependent on complement factor 5 (C5) – an ex vivo study with blood from a C5‐deficient individual
(Journal article, 2018)The aim of the study was to investigate the role of complement factor 5 (C5) in reactions elicited by plasma separation using blood from a C5‐deficient (C5D) individual, comparing it to C5‐deficient blood reconstituted ... -
GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients
(Journal article; Peer reviewed, 2019)Background In breast cancer, activation of bone morphogenetic protein (BMP) signaling and elevated levels of BMP-antagonists have been linked to tumor progression and metastasis. However, the simultaneous upregulation of ... -
Growth and survival of follicular and diffuse large B cell lymphoma cells: the role of toll-like receptors and their ligands, IL-21, BMP-4 and BMP-6
(Master thesis, 2010)The main purpose of this thesis was to characterize the expression of toll-like receptors (TLRs) and to investigate the role of TLR-induced responses in growth and survival of follicular lymphoma (FL) and diffuse large ...