Blar i Institutt for klinisk og molekylær medisin på tittel

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    • Cytokine profiling as a measure of immunological development and deviation throughout pregnancy in healthy women and women with PCOS 

      Stokkeland, Live Marie Tobiesen (Doctoral theses at NTNU;2022:183, Doctoral thesis, 2022)
      Norsk sammendrag Cytokinprofilering som mål på immunologiske forandringer gjennom svangerskapet hos friske kvinner og kvinner med PCOS Mors immunsystem tilpasser seg gjennom de ulike fasene av svangerskapet for å sikre ...

    • Cytokine responses, microbial aetiology and short-term outcome in community-acquired pneumonia 

      Siljan, William Ward; Holter, Jan Cato; Nymo, Ståle Haugset; Husebye, Einar; Ueland, Thor; Aukrust, Pål; Mollnes, Tom Eirik; Heggelund, Lars (Journal article; Peer reviewed, 2017)
      Background The inflammatory response to community-acquired pneumonia (CAP) is orchestrated through activation of cytokine networks and the complement system. We examined the association of multiple cytokines and the ...

    • Cytokines in Relation to Motor Activity in an Acute Psychiatric Population 

      Larsen, Jeanette Brun; Stunes, Astrid Kamilla; Iversen, Valentina Cabral; Vaaler, Arne; Reitan, Solveig Merete Klæbo (Peer reviewed; Journal article, 2019)
      Background: Deviations in motor activity are important clinical features of several psychiatric disorders in an acute state. Immune activity is associated with several psychiatric disorders and may affect motor activity. ...

    • Cytomegalovirus antibody status at 17 - 18 weeks of gestation and preeclampsia: a case-control study of pregnant women in Norway 

      Strand, Kristin Melheim; Odland, Maria Lisa; Iversen, Ann-Charlotte; Nordbø, Svein Arne; Vik, Torstein; Austgulen, Rigmor (Journal article; Peer reviewed, 2012)
      Objective To assess the association between maternal cytomegalovirus (CMV) antibodies in mid-pregnancy and preeclampsia. Design Nested case–control study. Setting Pregnancies registered in the Norwegian Mother and ...

    • Cytosolic Phospholipase A2 Alpha Regulates TLR Signaling and Migration in Metastatic 4T1 Cells 

      Tunset, Hanna Maja; Feuerherm, Astrid Jullumstrø; Selvik, Linn-Karina M.; Johansen, Berit; Moestue, Siver Andreas (Journal article; Peer reviewed, 2019)
      Metastatic disease is the leading cause of death in breast cancer patients. Disrupting the cancer cell’s ability to migrate may be a strategy for hindering metastasis. Cytosolic phospholipase A2 α (cPLA2α), along with ...

    • Cytosolic scaffold functions of PCNA 

      Olaisen, Camilla (Doctoral theses at NTNU;2017:203, Doctoral thesis, 2017)
      PCNA som et plattform-protein i cytosol Kroppen vår består av millioner av celler som alle stammer fra en enkelt celle. For hver celledeling må arvestoffet, DNA-et, kopieres feilfritt i et samarbeid mellom mange ulike ...

    • Cytotoxic Effect on Human Myeloma Cells and Leukemic Cells by the Agaricus blazei Murill Based Mushroom Extract, Andosan™ 

      Tangen, Jon-Magnus; Holien, Toril; Mirlashari, Mohammad Reza; Misund, Kristine; Hetland, Geir (Journal article; Peer reviewed, 2017)
      Agaricus blazei Murill is an edible mushroom of the Basidiomycetes family, which has been found to contain a number of compounds with antitumor properties, such as proteoglycans and ergosterol. In the present investigation, ...

    • Cytotoxicity and effect on wound re-epithelialization after topical administration of tranexamic acid 

      Eikebrokk, Tuva; Vassmyr, Brita; Ausen, Kjersti; Gravastrand, Caroline S.; Spigset, Olav; Pukstad, Brita (Journal article; Peer reviewed, 2019)
      Background Topical administration of tranexamic acid (TXA) reduces bleeding from surgical wounds similarly to intravenous use, but with negligible risk of adverse systemic events. Topical use is expanding, but is ...

    • Cytotoxicity and repair of uracil and 5-fluorouracil in DNA 

      Pettersen, Henrik Sahlin (Doktoravhandlinger ved NTNU, 1503-8181; 2011:95, Doctoral thesis, 2011)
      Cytotoksisitet og reparasjon av uracil og 5-fluorouracil i DNA Vårt arvemateriale (gener) er organisert i 23 kromosompar, som det finnes fullstendige kopier av i storparten av våre celler. Hvert kromosom består av en lang ...

    • Cytotoxicity of poly(Alkyl cyanoacrylate) nanoparticles 

      Sulheim, Einar; Iversen, Tore Geir; To, Vu; Klinkenberg, Geir; Sletta, Håvard; Schmid, Ruth; Hatletveit, Anne Rein; Wågbø, Ane Marit; Sundan, Anders; Skotland, Tore; Sandvig, Kirsten; Mørch, Ýrr Asbjørg (Journal article; Peer reviewed, 2017)
      Although nanotoxicology has become a large research field, assessment of cytotoxicity is often reduced to analysis of one cell line only. Cytotoxicity of nanoparticles is complex and should, preferentially, be evaluated ...

    • Dansk embryologikompendium 

      Stridsklev, Solhild (Peer reviewed; Journal article, 2021)
      Kompendiet er først og fremst rettet mot medisinstudenter, men kan leses av alle med interesse for feltet eller ønske om en kort repetisjon av embryologien. Det er kortfattet og nærmest stikkordspreget, i A4-størrelse og ...

    • Dasatinib induces fast and deep responses in newly diagnosed chronic myeloid leukaemia patients in chronic phase: Clinical results from a randomised phase-2 study (NordCML006) 

      Hjorth-Hansen, Henrik; Stenke, Leif; Söderlund, Stina; Dreimane, Arta; Ehrencrona, Hans; Gedde-Dahl, Thobias; Gjertsen, Bjørn Tore; Höglund, Martin; Koskenvesa, Perttu; Lotfi, Kourosh; Majeed, Mohammed Waleed; Markevärn, Berit; Ohm, Lotta; Olsson-Strömberg, Ulla; Remes, Kari; Suominen, Merja; Simonsson, Bengt; Porkka, Kimmo; Mustjoki, Satu; Richter, Johan (Journal article, 2015)
      We randomised 46 newly diagnosed patients with chronic myeloid leukaemia (median age 56) to receive dasatinib 100 mg QD or imatinib 400 mg QD and report outcome as an intention-to-treat analysis with 36 months follow-up. ...

    • Decidual and placental NOD1 is associated with inflammation in normal and preeclamptic pregnancies 

      Rakner, Johanne Johnsen; Silva, Gabriela; Mundal, Siv Boon; Thaning, Astrid Josefin; Elschot, Mattijs; Ostrop, Jenny; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Gierman, Lobke; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2021)
      Introduction: Inflammation is a normal physiological process that increases to harmful levels in preeclampsia. It affects the interaction between maternal immune cells and fetal trophoblasts at both sites of the maternal-fetal ...

    • Decidual gene expression analysis: Endoplasmic reticulum stressand oxidative stress asprobable major events in thepatho physiology of preeclampsia 

      Løset, Mari; Mundal, Siv Boon (Master thesis, 2009)

    • Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations 

      Boer, Cindy G.; Hatzikotoulas, Konstantinos; Southam, Lorraine; Stefánsdóttir, Lilja; Almeida, Rodrigo Coutinho de; Zhang, Yanfei; Wu, Tian T.; Zheng, Jie; Hartley, April; Teder-Laving, Maris; Skogholt, Anne Heidi; Terao, Chikashi; Zengini, Eleni; Alexiadis, George; Barysenka, Andrei; Bjornsdottir, Gyda; Gabrielsen, Maiken Elvestad; Gilly, Arthur; Ingvarsson, Thorvaldur; Johnsen, Marianne Bakke; Jonsson, Helgi; Kloppenburg, Margreet; Luetge, Almut; Lund, Sigrun H; Magi, Reedik; Mangino, Massimo; Nelissen, Rob G.H.H.; Shivakumar, Manu; Steinberg, Julia; Takuwa, Hiroshi; Thomas, Laurent; Tuerlings, Margo; Babis, George C.; Cheung, Jason Pui Yin; Kang, Jae Hee; Kraft, Peter; Lietman, Steven A.; Samartzis, Dino; Slagboom, P. Eline; Stefansson, Kari; Thorsteinsdottir, Unnur; Tobias, Jonathan H.; Uitterlinden, André G.; Winsvold, Bendik K S; Zwart, John Anker Henrik; Smith, George Davey; Sham, Pak Chung; Thorleifsson, Gudmar; Hveem, Kristian; Zeggini, Eleftheria (Peer reviewed; Journal article, 2021)
      Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated ...

    • Deciphering role of succinate in metabolic rewiring of innate immunity 

      Sabbir, Ahmed (Master thesis, 2021)
      Succinate is the anionic form of succinic acid, which is produced during adenosine triphosphate (ATP) synthesis via the tricarboxylic acid (TCA) cycle. In a biological system, succinate can be found in two forms. One is ...

    • Deciphering the pathomolecular mechanisms underlying thoracic aortic aneurysm formation in syndromic patients 

      Pulli, Hanna Riina Elina (Master thesis, 2022)
      A thoracic aortic aneurysm (TAA) is local dilatation that occurs in the major blood vessel from which blood flows to the aorta. In the worst case, weakened dilation can lead to rupture. Clinical decision making for the ...

    • Decoding the Metabolic Reprogramming Underlying Toll-like Receptor Signaling 

      Kim, Hera (Doctoral theses at NTNU;2021:297, Doctoral thesis, 2021)

    • Decrease in use of manual vacuum aspiration in postabortion care in Malawi: A cross-sectional study from three public hospitals, 2008-2012 

      Odland, Maria Lisa; Rasmussen, Hanne; Jacobsen, Geir Wenberg; Kafulafula, UK; Chamanga, P; Odland, Jon Øyvind (Journal article; Peer reviewed, 2014)
      Objectives: To investigate the use of manual vacuum aspiration in postabortion care in Malawi between 2008–2012. Methods: A retrospective cross-sectional study was done at the referral hospital Queen Elisabeth Central ...

    • Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity 

      Castela, Inês; Morais, Juliana; Barreiros-Mota, Inês; Silvestre, Marta P.; Marques, Cláudia; Rodrigues, Catarina; Ismael, Shámila; Araújo, João R; Ângelo-Dias, Miguel; Martins, Catarina; Borrego, Luís Miguel; Monteiro, Rosário; dos Santos Ribeiro F. Coutinho, Silvia; Calhau, Conceição; Alho Letra Martins, Catia Patricia; Faria, Ana; Pestana, Diogo; Teixeira, Diana (Journal article; Peer reviewed, 2023)
      Adiponectin/leptin ratio, triacylglycerols, and waist-to-hip ratio explained almost half of HOMA-IR variance in the context of obesity. This study provides evidence to support adipose tissue dysfunction as a central feature ...