Blar i Institutt for klinisk og molekylær medisin på tittel

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    • Complement lectin pathway protein levels reflect disease activity in juvenile idiopathic arthritis: A longitudinal study of the Nordic JIA cohort 

      Glerup, Mia; Thiel, Steffen; Rypdal, Veronika Gjertsen; Arnstad, Ellen Dalen; Ekelund, Maria; Peltoniemi, Suvi; Aalto, Kristiina; Rygg, Marite; Nielsen, Susan; Fasth, Anders; Berntson, Lillemor; Nordal, Ellen Berit; Herlin, Troels (Journal article; Peer reviewed, 2019)
      Background To determine the serum levels of the lectin pathway proteins early in the disease course and 17 years after disease onset and to correlate the protein levels to markers of disease activity in participants ...

    • Complement ratios C3bc/C3 and sC5b-9/C5 do not increase the sensitivity of detecting acute complement activation systemically 

      Thomas, Anub Mathew; Chaban, Viktoriia; Pischke, Soeren; Orrem, Hilde Lang; Bosnes, Vidar; Sunde, Kjetil; Seljeflot, Ingebjørg; Lundqvist, Christofer; Nakstad, Espen Rostrup; Andersen, Geir Øystein; Schjalm, Camilla; Mollnes, Tom Eirik; Barratt-Due, Andreas (Peer reviewed; Journal article, 2021)
      Background Complement activation plays an important pathogenic role in numerous diseases. The ratio between an activation product and its parent protein is suggested to be more sensitive to detect complement activation ...

    • Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism 

      Arbore, Giuseppina; West, Erin; Rahman, Jubayer; Le Friec, Gaelle; Niyonzima, Nathalie; Mehdi, Pirooznia; Ilker, Tunc; Polychronis, Pavlidis; Nicholas, Powell; Li, Yuesheng; Liu, Poching; Servais, Aude; Couzi, Lionel; Fremeaux-Bacchi, Veronique; Placais, Leo; Ferraro, Alastair; Walsh, Patrick R.; Kavanagh, David; Afzali, Behdad; Lavender, Paul; Lachmann, Helen J.; Kemper, Claudia (Journal article; Peer reviewed, 2018)
      The induction of human CD4+ Th1 cells requires autocrine stimulation of the complement receptor CD46 in direct crosstalk with a CD4+ T cell-intrinsic NLRP3 inflammasome. However, it is unclear whether human cytotoxic CD8+ ...

    • Completeness and correctness of cerebral palsy diagnoses in two health registers: implications for estimating prevalence 

      Hollung, Sandra Julsen; Vik, Torstein; Wiik, Robert; Bakken, Inger Johanne; Andersen, Guro Lillemoen (Journal article; Peer reviewed, 2017)
      Aim To assess completeness and correctness of cerebral palsy (CP) diagnoses in the Cerebral Palsy Register of Norway (CPRN) and the Norwegian Patient Register (NPR), and to estimate CP prevalence. Method Among 747 883 ...

    • Completion surgery vs. primary TME for early rectal cancer: a national study 

      Lossius, William J; Stornes, Tore; Myklebust, Tor Åge; Endreseth, Birger Henning; Wibe, Arne (Journal article; Peer reviewed, 2021)
      Purpose While local excision by transanal endoscopic microsurgery (TEM) or transanal minimally invasive surgery (TAMIS) is an option for low-risk early rectal cancers, inaccuracies in preoperative staging may be revealed ...

    • Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform 

      Berges, Natalia; Nawaz, Meh Sameen; Dahl, Tuva Børresdatter; Hagen, Lars; Bjørås, Magnar; Lærdahl, Jon Kristen; Alseth, Ingrun (Journal article; Peer reviewed, 2019)
      Endonuclease V (ENDOV) is a ribonuclease with affinity for inosine which is the deamination product of adenosine. The genomes of most organisms, including human, encode ENDOV homologs, yet knowledge about in vivo functions ...

    • The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants 

      Rio-Machin, Ana; Villiamy, Tom; Hug, Nele; Walne, Amanda; Tawana, Kiran; Cardoso, Shirleny; Ellison, Alicia; Pontikos, Nikolas; Wang, Jun; Tummala, Hemanth; Al Seraihi, Ahad Fahad H.; Alnajar, Jenna; Bewicke-Copley, Findlay; Barnett, Michael; Armes, Hannah; Bloor, Adrian; Bödör, Csabo; Bowen, David; Fenaux, Pierre; Green, Andrew; Hallahan, Andrew; Hjorth-Hansen, Henrik; Hossein, Upal; Killick, Sally; Lawson, Sarah; Layton, Mark; Male, Alison M.; Marsh, Judith; Mehta, Priyanka; Mous, Rogier; Nomdedéu, Josep F.; Owen, Carolyn; Pavlu, Jiri; Payne, Elspeth; Protheroe, Rachel E.; Preudhomme, Claude; Pujol-Moix, Nuria; Renneville, Aline; Russell, Nigel; Saggar, Anand; Sciuccati, Gabriela; Taussig, David; Toze, Cynthia; Uyttebroeck, Anne; Vandenberghe, Peter; Schlegelberger, Brigitte; Ripperger, Tim; Steinemann, Doris; Wu, John; Mason, Joanne; Page, Paula; Akiki, Susanna; Reay, Kim; Cavenagh, Jamie D.; Plagnol, Vincent; Caceres, Javier F.; Fitzgibbon, Jude; Dokal, Inderjeet (Peer reviewed; Journal article, 2020)
      The inclusion of familial myeloid malignancies as a separate disease entity in the revised WHO classification has renewed efforts to improve the recognition and management of this group of at risk individuals. Here we ...

    • Compo: composite motif discovery using discrete models 

      Sandve, Geir Kjetil; Abul, Osman; Drabløs, Finn (Journal article; Peer reviewed, 2008)
      Background: Computational discovery of motifs in biomolecular sequences is an established field, with applications both in the discovery of functional sites in proteins and regulatory sites in DNA. In recent years there ...

    • Comprehensive mismatch repair gene panel identifies variants in patients with Lynch-like syndrome 

      Xavier, Alexandre; Olsen, Maren Fridtjofsen; Lavik, Liss Ane; Johansen, Jostein; Singh, Ashish Kumar; Sjursen, Wenche; Scott, Rodney J.; Talseth-Palmer, Bente Anita (Journal article; Peer reviewed, 2019)
      AbstractBackground: Lynch‐like syndrome (LLS) represents around 50% of the patients fulfilling the Amsterdam Criteria II/revised Bethesda Guidelines, characterized by a strong family history of Lynch Syndrome (LS) ...

    • Comprehensive protocols for culturing and molecular biological analysis of IBD patient-derived colon epithelial organoids 

      Gopalakrishnan, Shreya; Bakke, Ingunn; Hansen, Marianne Dore; Skovdahl, Helene Kolstad; Granlund, Atle van Beelen; Sandvik, Arne Kristian; Bruland, Torunn (Journal article; Peer reviewed, 2023)

    • Comprehensive small RNA-sequencing of primary myeloma cells identifies miR-105-5p as a predictor of patient survival 

      Aass, Kristin Roseth; Nedal, Tonje Marie Vikene; Bouma, Siri Anshushaug; Tryggestad, Synne Stokke; Haukås, Einar; Slørdahl, Tobias Schmidt; Waage, Anders; Standal, Therese; Mjelle, Robin (Journal article; Peer reviewed, 2022)

    • Comprehensive transcriptomic analyses of tissue, serum, and serum exosomes from hepatocellular carcinoma patients 

      Mjelle, Robin; Dima, Simona O.; Bacalbasa, Nicolae; Chawla, Konika; Sorop, Andrei; Cucu, Dana; Herlea, Vlad; Sætrom, Pål; Popescu, Irinel (Journal article; Peer reviewed, 2019)
      Background The expression of microRNAs (miRNAs) is a promising prognostic and diagnostic tool in hepatocellular carcinoma (HCC). Here we performed small RNA sequencing (sRNA-seq) of tissue, serum and serum exosomes to ...

    • Computational Analysis of DNA Methylation and Gene Expression Patterns in Prostate Cancer 

      Rauluševičiūtė, Ieva (Master thesis, 2018)
      DNA methylation is an important contributor for prostate cancer development and progression. It has been studied experimentally for years, but, lately, high-throughput technologies are able to produce genome-wide DNA ...

    • Computational analysis of regulatory mechanism and interactions of microRNAs 

      Saito, Takaya (Doktoravhandlinger ved NTNU, 1503-8181; 2011:314, Doctoral thesis, 2011)
      For years, RNAs were thought to have only two broad functions in cells, transmitting information between DNA and protein as messenger RNA (mRNA), and playing structural, catalytic, information decoding roles in protein ...

    • Computational Analysis of Short Linear Motifs in the Spike Protein of SARS-CoV-2 Variants Provides Possible Clues into the Immune Hijack and Evasion Mechanisms of Omicron Variant 

      Soorajkumar, Anjana; Alakraf, Ebrahim; Uddin, Mohammed; Du Plessis, Stefan S.; Alsheikh-Ali, Alawi; Kandasamy, Richard Kumaran (Peer reviewed; Journal article, 2022)
      Short linear motifs (SLiMs) are short linear sequences that can mediate protein–protein interaction. Mimicking eukaryotic SLiMs to compete with extra- or intracellular binding partners, or to sequester host proteins is the ...

    • Computational Drug Repositioning and Experimental Validation of Ivermectin in Treatment of Gastric Cancer 

      Rabben, Hanne-Line; Andersen, Gøran Troseth; Ianevski, Aleksandr; Olsen, Magnus Kringstad; Kainov, Denis; Grønbech, Jon Erik; Wang, Timothy Cragin; Chen, Duan; Zhao, Chun-Mei (Peer reviewed; Journal article, 2021)
      Objective: The aim of the present study was repositioning of ivermectin in treatment of gastric cancer (GC) by computational prediction based on gene expression profiles of human and mouse model of GC and validations with ...

    • Computational Modeling of Motile Cilia-Driven Cerebrospinal Flow in the Brain Ventricles of Zebrafish Embryo 

      Salman, Huseyin Enes; Jurisch-Yaksi, Nathalie; Yalcin, Huseyin Cagatay (Peer reviewed; Journal article, 2022)
      Motile cilia are hair-like microscopic structures which generate directional flow to provide fluid transport in various biological processes. Ciliary beating is one of the sources of cerebrospinal flow (CSF) in brain ...

    • Computational tools for exploring peptide-membrane interactions in gram-positive bacteria 

      Kumar, Shreya; Balaya, Rex Devasahayam Arokia; Kanekar, Saptami; Raju, Rajesh; Prasad, Thottethodi Subrahmanya; Kandasamy, Richard Kumaran (Peer reviewed; Journal article, 2023)
      The vital cellular functions in Gram-positive bacteria are controlled by signaling molecules known as quorum sensing peptides (QSPs), considered promising therapeutic interventions for bacterial infections. In the bacterial ...

    • Computationally efficient familywise error rate control in genome‐wide association studies using score tests for generalized linear models 

      Halle, Kari Krizak; Bakke, Øyvind; Djurovic, Srdjan; Bye, Anja; Ryeng, Einar; Wisløff, Ulrik; Andreassen, Ole Andreas; Langaas, Mette (Peer reviewed; Journal article, 2020)
      In genetic association studies, detecting phenotype–genotype association is a primary goal. We assume that the relationship between the data—phenotype, genetic markers and environmental covariates—can be modeled by a ...

    • Computer-based video analysis identifies infants with absence of fidgety movements 

      Støen, Ragnhild; Songstad, Nils Thomas; Silberg, Inger Elisabeth; Fjørtoft, Toril Synnøve Larsso; Jensenius, Alexander Refsum; Adde, Lars (Journal article; Peer reviewed, 2017)
      Background: Absence of fidgety movements (FMs) at 3 months’ corrected age is a strong predictor of cerebral palsy (CP) in high-risk infants. This study evaluates the association between computer-based video analysis and ...