Blar i Institutt for klinisk og molekylær medisin på tittel
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Complement Activation in 22q11.2 Deletion Syndrome
(Peer reviewed; Journal article, 2020)The 22q11.2 deletion syndrome (22q11.2 del), also known as DiGeorge syndrome, is a genetic disorder with an estimated incidence of 1:3000 to 1:6000 births. These patients may suffer from affection of many organ systems ... -
Complement activation is a crucial pathogenic factor in catastrophic antiphospholipid syndrome.
(Journal article; Peer reviewed, 2016) -
Complement activation is associated with poor outcome after out-of-hospital cardiac arrest
(Peer reviewed; Journal article, 2021)Background Cardiopulmonary resuscitation after cardiac arrest initiates a whole-body ischemia-reperfusion injury, which may activate the innate immune system, including the complement system. We hypothesized that complement ... -
Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood
(Journal article; Peer reviewed, 2022) -
A complement C3–Specific nanobody for modulation of the alternative cascade identifies the C-Terminal domain of C3b as functional in C5 convertase activity
(Peer reviewed; Journal article, 2020)The complement system is an intricate cascade of the innate immune system and plays a key role in microbial defense, inflammation, organ development, and tissue regeneration. There is increasing interest in developing ... -
Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli-induced coagulation accompanied by Toll-like receptor 4.
(Journal article; Peer reviewed, 2018)There is a close cross‐talk between complement, Toll‐like receptors (TLRs) and coagulation. The role of the central complement component 5 (C5) in physiological and pathophysiological hemostasis has not, however, been fully ... -
Complement component C3 and the TLR co-receptor CD14 are not involved in angiotensin II induced cardiac remodelling
(Peer reviewed; Journal article, 2020)Inflammation is centrally involved in the development of cardiac hypertrophy and the processes of remodelling. The complement system and Toll-like receptor (TLR) family, two upstream arms of the innate immune system, have ... -
Complement component C5 and TLR molecule CD14 mediate heme-induced thromboinflammation in human blood
(Journal article; Peer reviewed, 2019)Heme is a critical danger molecule liberated from hemeproteins in various conditions, including from hemoglobin in hemolytic diseases. Heme may cause thromboinflammatory damage by activating inflammatory and hemostatic ... -
Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function
(Journal article; Peer reviewed, 2017)Inhibition of complement factor 5 (C5) reduced myocardial infarction in animal studies, while no benefit was found in clinical studies. Due to lack of cross-reactivity of clinically used C5 antibodies, different inhibitors ... -
Complement factors B, D, C3bBbP and risk of future venous thromboembolism
(Peer reviewed; Journal article, 2023)The complement system appears to be involved in the pathogenesis of venous thromboembolism (VTE). We investigated the association of complement factors (CF) B, D, and the alternative pathway convertase, C3bBbP, measured ... -
Complement in clinical medicine: Clinical trials, case reports and therapy monitoring
(Journal article; Peer reviewed, 2017)Research during past decades made it evident that complement is involved in more tasks than fighting infections, but has important roles in other immune surveillance and housekeeping functions. If the balance between ... -
Complement in sepsis — when science meets clinics
(Peer reviewed; Journal article, 2020)Sepsis as life‐threatening organ dysfunction caused by microorganisms represents a dreadful challenge for the immune system. The role of the complement system as major column of innate immunity has been extensively studied ... -
Complement Is Activated During Normothermic Machine Perfusion of Porcine and Human Discarded Kidneys
(Peer reviewed; Journal article, 2022)Background: The gap between demand and supply of kidneys for transplantation necessitates the use of kidneys from extended criteria donors. Transplantation of these donor kidneys is associated with inferior results, reflected ... -
Complement lectin pathway protein levels reflect disease activity in juvenile idiopathic arthritis: A longitudinal study of the Nordic JIA cohort
(Journal article; Peer reviewed, 2019)Background To determine the serum levels of the lectin pathway proteins early in the disease course and 17 years after disease onset and to correlate the protein levels to markers of disease activity in participants ... -
Complement ratios C3bc/C3 and sC5b-9/C5 do not increase the sensitivity of detecting acute complement activation systemically
(Peer reviewed; Journal article, 2021)Background Complement activation plays an important pathogenic role in numerous diseases. The ratio between an activation product and its parent protein is suggested to be more sensitive to detect complement activation ... -
Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism
(Journal article; Peer reviewed, 2018)The induction of human CD4+ Th1 cells requires autocrine stimulation of the complement receptor CD46 in direct crosstalk with a CD4+ T cell-intrinsic NLRP3 inflammasome. However, it is unclear whether human cytotoxic CD8+ ... -
Completeness and correctness of cerebral palsy diagnoses in two health registers: implications for estimating prevalence
(Journal article; Peer reviewed, 2017)Aim To assess completeness and correctness of cerebral palsy (CP) diagnoses in the Cerebral Palsy Register of Norway (CPRN) and the Norwegian Patient Register (NPR), and to estimate CP prevalence. Method Among 747 883 ... -
Completion surgery vs. primary TME for early rectal cancer: a national study
(Journal article; Peer reviewed, 2021)Purpose While local excision by transanal endoscopic microsurgery (TEM) or transanal minimally invasive surgery (TAMIS) is an option for low-risk early rectal cancers, inaccuracies in preoperative staging may be revealed ... -
Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform
(Journal article; Peer reviewed, 2019)Endonuclease V (ENDOV) is a ribonuclease with affinity for inosine which is the deamination product of adenosine. The genomes of most organisms, including human, encode ENDOV homologs, yet knowledge about in vivo functions ... -
The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants
(Peer reviewed; Journal article, 2020)The inclusion of familial myeloid malignancies as a separate disease entity in the revised WHO classification has renewed efforts to improve the recognition and management of this group of at risk individuals. Here we ...