Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 447-466 of 2120
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Depletion of the human N-terminal acetyltransferase hNaa30 disrupts Golgi integrity and ARFRP1 localization
(Journal article; Peer reviewed, 2017)The organization of the Golgi apparatus (GA) is tightly regulated. Golgi stack scattering is observed in cellular processes such as apoptosis and mitosis, and has also been associated with disruption of cellular lipid ... -
Depression and Depressive Symptoms in Advanced Cancer Patients - Assessment, Classification and Treatment
(Doctoral thesis at NTNU;2015:199, Doctoral thesis, 2015)Summary in Norwegian: Depresjon og symptomer på depresjon – kartlegging, klassifisering og behandling Depresjon og depressive symptomer er en belastning for pasienter med langtkommen kreft. Anslag som er gjort av ... -
Depression in palliative care cancer patients - Assessment and classification
(Doctoral theses at NTNU;2018:12, Doctoral thesis, 2018)Palliative care aims at improving quality of life and reducing suffering in patients with lifethreatening illness through the early identification, assessment and treatment of problems. Depression reduces quality of life ... -
Depression-A Major Contributor to Poor Quality of Life in Patients With Advanced Cancer
(Journal article, 2017)Context Quality of life (QoL) and depression are important patient-reported outcomes in cancer care. However, the relative importance of depression severity in predicting QoL remains unclear because of few methodologically ... -
Detailed flow visualization in fetal and neonatal hearts using 2-D speckle tracking
(Journal article, 2016)Two-dimensional blood speckle tracking has shown promise for measuring the complex flow patterns in neonatal hearts when based on linear array and high-frame-rate plane wave imaging. For phased array pediatric imaging, ... -
Detailed statistical analysis plan for the Danish Palliative care trial (DanPaCT)
(Journal article; Peer reviewed, 2014)Background Advanced cancer patients experience considerable symptoms, problems, and needs. Early referral of these patients to specialized palliative care (SPC) could offer improvements. The Danish Palliative Care Trial ... -
Detecting Toll-Like Receptor 8
(Master thesis, 2020)Toll-lignende reseptorer (TLR)er er reseptorer i det iboende immunsystemet som kan binde et bredt utvalg av mikrobe-tilknyttede molekylære mønstre (MAMP)s. Ved deres aktivering, utløses et bredt spekter av cellulære ... -
Detection and differentiation of breast cancer sub-types using a cPLA2a activatable fluorophore
(Journal article; Peer reviewed, 2019)Cytosolic phospholipase A2α (cPLA2α) has been shown to be elevated in breast cancer and is a potential biomarker in the differentiation of molecular sub-types. Using a cPLA2α activatable fluorophore, DDAO arachidonate, we ... -
Detection of congenital heart defects in a non-selected population of 42,381 fetuses
(Doktoravhandlinger ved NTNU, 1503-8181; 2006:112, Doctoral thesis, 2006)Bakgrunn Siden 1986 har alle gravide i Norge fått tilbud om en ultralydundersøkelse ved 18 uker i svangerskapet. En av hensiktene med undersøkelsen er å oppdage sykdom hos fosteret for å optimalisere oppfølging, tidspunkt ... -
Detection of spliced mRNA from human bocavirus 1 in clinical samples from children with respiratory tract infections
(Journal article; Peer reviewed, 2013)Human bocavirus 1 (HBoV1) is a parvovirus associated with respiratory tract infections (RTIs) in children, but a causal relation has not yet been confirmed. To develop a qualitative reverse transcription PCR to detect ... -
Deterioration in Muscle Mass and Physical Function Differs According to Weight loss History in Cancer Cachexia
(Journal article; Peer reviewed, 2019)Background: Muscle mass and physical function (PF) are common co-primary endpoints in cancer cachexia trials, but there is a lack of data on how these outcomes interact over time. The aim of this secondary analysis of data ... -
Determination of anti-anisakis simplex antibodies and relationship with αβ and γδ lymphocyte subpopulations in patients with Crohn's Disease
(Journal article; Peer reviewed, 2017)Background The etiology of Crohn’s disease (CD) is still unknown although new theories are based on defects in innate immunity. We have previously shown a decrease in γδ T cells in CD patients. Previous studies have shown ... -
Developing quantitative imaging of Akt activation in tissue sections
(Master thesis, 2012)The PI3K/mTOR pathway regulates fundamental cellular processes such as proliferation, growth, metabolism and autophagy. PI3K signalling is often constitutively activated in cancer cells and tumours. Chemical inhibitors ... -
Development and aging of cortical thickness correspond to genetic organization patterns
(Journal article; Peer reviewed, 2015)There is a growing realization that early life influences have lasting impact on brain function and structure. Recent research has demon- strated that genetic relationships in adults can be used to parcellate the cortex ... -
Development and course of chronic pain over 4 years in the general population: The HUNT pain study
(Journal article; Peer reviewed, 2018)Background Epidemiological studies of chronic pain frequently report high prevalence estimates. However, there is little information about the development and natural course of chronic pain. Methods We followed a ... -
Development and course of chronic widespread pain: the role of time and pain characteristics (the HUNT pain study)
(Journal article; Peer reviewed, 2019)Chronic widespread pain (CWP) is common and associated with loss of functioning and health. Subjects with chronic nonwidespread pain (CnWP) are at increased risk of developing CWP, but few studies have described the nature ... -
Development and Validation of the Both Hands Assessment for Children With Bilateral Cerebral Palsy
(Journal article; Peer reviewed, 2017)Aims: To develop a hand function test for children with bilateral cerebral palsy (CP) measuring bimanual performance, including quantification of possible asymmetry of hand use. Method: The Both Hands Assessment (BoHA) ... -
Development of a Biosensor Concept to Detect the Production of Cluster-Specific Secondary Metabolites
(Journal article; Peer reviewed, 2017)Genome mining of actinomycete bacteria aims at the discovery of novel bioactive secondary metabolites that can be developed into drugs. A new repressor-based biosensor to detect activated secondary metabolite biosynthesis ... -
Development of a deep inspiration breath-hold system for radiotherapy utilizing a laser distance measurer
(Journal article; Peer reviewed, 2017)Deep inspiration breath‐hold (DIBH) is a technique for treating left‐sided breast cancer (LSBC). In modern radiotherapy, one of the main aims is to exclude the heart from the beam aperture with an individualized beam design ... -
Development of a rapid and simplified protocol for direct bacterial identification from positive blood cultures by using matrix assisted laser desorption ionization time-of- flight mass spectrometry.
(Peer reviewed; Journal article, 2015)Background Bloodstream infections represent serious conditions carrying a high mortality and morbidity rate. Rapid identification of microorganisms and prompt institution of adequate antimicrobial therapy is of utmost ...