Blar i Institutt for klinisk og molekylær medisin på tittel

Viser treff 1879-1898 av 3426

    • Long-term temporal trends in incidence rate and case fatality of sepsis and COVID-19-related sepsis in Norwegian hospitals, 2008-2021: a nationwide registry study 

      Skei, Nina Vibeche; Nilsen, Tom Ivar Lund; Knoop, Siri Tandberg; Prescott, Hallie; Lydersen, Stian; Mohus, Randi Marie; Brkic, Alen; Liyanarachi, Kristin Vardheim; Solligård, Erik; Damås, Jan Kristian; Gustad, Lise Tuset (Peer reviewed; Journal article, 2023)
      Objectives To estimate temporal trends in incidence rate (IR) and case fatality during a 14-year period from 2008 to 2021, and to assess possible shifts in these trends during the COVID-19 pandemic. Setting All Norwegian ...

    • Long-term therapy in COPD: Any evidence of adverse effect on bone? 

      Langhammer, Arnulf; Forsmo, Siri; Syversen, Unni (Journal article; Peer reviewed, 2009)
      Patients with COPD have high risk for osteoporosis and fractures. Hip and vertebral fractures might impair mobility, and vertebral fractures further reduce lung function. This review discusses the evidence of bone loss due ...

    • Long-term trends in colorectal cancer: incidence, localization, and presentation 

      Høydahl, Øystein; Edna, Tom-Harald; Xanthoulis, Athanasios; Lydersen, Stian; Endreseth, Birger Henning (Peer reviewed; Journal article, 2020)
      Background The purpose of this study was to assess trends in incidence and presentation of colorectal cancer (CRC) over a period of 37 years in a stable population in Mid-Norway. Secondarily, we wanted to predict the ...

    • Long-term work outcomes and the efficacy of multidisciplinary rehabilitation programs on labor force participation in cancer patients - a protocol for a longitudinal prospective cohort study 

      Engan, Harald; Oldervoll, Line Merethe; Bertheussen, GF; Gaarder, MH; Nielsen, Roy; Paraponaris, Alain; Stene, GB; Tandstad, Torgrim; Torp, Steffen (Journal article; Peer reviewed, 2020)
      Background. Many cancer survivors experience late effects of cancer treatment and therefore struggle to return to work. Norway provides rehabilitation programs to increase labor force participation for cancer survivors ...

    • Longer Length of First Stay in Intermittent Residential Programmes Is Associated with Larger Weight Loss at 1 and 2 Years 

      Martins, Catia; Strømmen, Magnus; Kulseng, Bård (Journal article; Peer reviewed, 2013)
      Objective: To determine if length of first stay impacts on weight loss and cardiovascular fitness, at 1 and 2 years in severely obese patients enrolled in intermittent residential programs. Methods: In a retrospective ...

    • LongITools: Dynamic longitudinal exposome trajectories in cardiovascular and metabolic noncommunicable diseases 

      Ronkainen, Justiina; Nedelec, Rozenn; Atehortua, Angelica; Balkhiyarova, Zhanna; Cascarano, Anna; Dang, Vien Ngoc; Elhakeem, Ahmed; Van Enckevort, Esther; Soares, Ana Goncalves; Haakma, Sido; Halonen, Miia; Heilb, Katharina F.; Heiskala, Anni; Hyde, Eleanor; Jacquemin, Bénédicte; Keikkala, Elina; Kerckhoffs, Jules; Klåvus, Anton; Kopinska, Joanna A.; Lepeule, Johanna; Marazzi, Francesca; Motoc, Irina; Näätänen, Mari; Ribbenstedt, Anton; Rundblad, Amanda; Savolainen, Otto; Simonetti, Valentina; De Toro Eadie, Nina; Tzala, Evangelia; Ulrich, Anna; Wright, Thomas; Zarei, Iman; D'Amicov, Enrico; Belotti, Federico; Bruniu, Carl; Castleton, Christopher; Charles, Marie-Aline; Gaillard, Romy; Hanhineva, Kati; Hoek, Gerard; Holven, Kirsten Bjørklund; Jaddoe, Vincent W. V.; Kaakinen, Marika A.; Kajantie, Eero Olavi; Kavousi, Maryam; Lakka, Timo; Matthews, Jason; Mortari, Andrea Piano; Vääräsmäki, Marja; Voortman, Trudy; Webster, Claire; Zinsm, Marie; Atella, Vincenzo; Bulgheroni, Maria; Chadeau-Hyam, Marc; Conti, Gabriella; Evans, Jayne; Felix, Janine F.; Heude, Barbara; Järvelin, Marjo-Riitta; Kolehmaine, Marjukka; Landberg, Rikard; Lekadir, Karim; Parusso, Stefano; Prokopenko, Inga; De Rooij, Susanne R.; Roseboom, Tessa; Swertz, Morris; Timpson, Nicholas; Ulven, Stine Marie; Vermeulen, Roel; Juola, Teija; Sebert, Sylvain (Peer reviewed; Journal article, 2022)
      The current epidemics of cardiovascular and metabolic noncommunicable diseases have emerged alongside dramatic modifications in lifestyle and living environments. These correspond to changes in our “modern” postwar societies ...

    • Longitudinal Associations between Exercise and Pain in the General Population - The HUNT Pain Study 

      Landmark, Tormod; Romundstad, Pål Richard; Borchgrevink, Petter Chr.; Kaasa, Stein; Dale, Ola (Journal article; Peer reviewed, 2013)
      Background: Population-based studies have reported conflicting findings on the relationship between physical activity and pain, and most studies reporting a relationship are cross sectional. Temporal relationships are ...

    • Longitudinal Associations Between Persistent Post-Concussion Symptoms and Blood Biomarkers of Inflammation and CNS-Injury Following Mild Traumatic Brain Injury 

      Clarke, Gerard Janez; Skandsen, Toril; Zetterberg, Henrik; Follestad, Turid; Einarsen, Cathrine Elisabeth; Vik, Anne; Mollnes, Tom Eirik; Pischke, Soeren; Blennow, Kaj; Håberg, Asta (Peer reviewed; Journal article, 2023)
      The aim of our study was to investigate the biological underpinnings of persistent post-concussion symptoms (PPCS) at 3 months following mild traumatic brain injury (mTBI). Patients (n = 192, age 16–60 years) with mTBI, ...

    • Longitudinal Changes in Circulating Metabolites and Lipoproteins After Breast Cancer Treatment 

      Giskeødegård, Guro F.; Madssen, Torfinn Støve; Sangermani, Matteo; Lundgren, Steinar; Wethal, Torgeir; Andreassen, Trygve; Reidunsdatter, Randi Johansen; Bathen, Tone Frost (Peer reviewed; Journal article, 2022)
      The multimodal treatment of breast cancer may induce long term effects on the metabolic profile and increase the risk of future cardiovascular disease. In this study, we characterized longitudinal changes in serum lipoprotein ...

    • Longitudinal changes in plasma hemopexin and alpha-1-microglobulin concentrations in women with and without clinical risk factors for pre-eclampsia 

      Murtoniemi, Katja; Kalapotharakos, Grigorios; Vahlberg, Tero; Raikkonen, Katri; Kajantie, Eero Olavi; Hämäläinen, Esa; Åkerstrom, Bo; Villa, Pia M.; Hansson, Stefan R.; Laivuori, Hannele (Peer reviewed; Journal article, 2019)
      Recent studies have shown increased concentration of fetal hemoglobin (HbF) in pre-eclamptic women. Plasma hemopexin (Hpx) and alpha-1-microglobulin (A1M) are hemoglobin scavenger proteins that protect against toxic effects ...

    • Longitudinal minimal residual disease assessment in multiple myeloma patients in complete remission - results from the NMSG flow-MRD substudy within the EMN02/HO95 MM trial 

      Schmitz, Alexander; Brøndum, Rasmus Froberg; Johnsen, Hans Erik; Mellqvist, Ulf-Henrik; Waage, Anders; Gimsing, Peter; Op Bruinink, Davine Hofste; van der Velden, Vincent; van der Holt, Bronno; Hansson, Markus; Andersen, Niels Frost; Frølund, Ulf Christian; Helleberg, Carsten; Schjesvold, Fredrik Hellem; Ahlberg, Lucia; Gulbrandsen, Nina; Andreasson, Bjorn; Lauri, Birgitta; Haukås, Einar; Bødker, Julie Støve; Roug, Anne Stidsholt; Bøgsted, Martin; Severinsen, Marianne T.; Gregersen, Henrik; Abildgaard, Niels; Sonneveld, Pieter; Dybkær, Karen (Peer reviewed; Journal article, 2022)
      Background Multiple myeloma remains an incurable disease with multiple relapses due to residual myeloma cells in the bone marrow of patients after therapy. Presence of small number of cancer cells in the body after cancer ...

    • Longitudinal ultrasound measures of fetal growth and offspring outcomes 

      Larose, Tricia L; Turner, Steve W; Hutcheon, Jennifer A; Rogne, Tormod; Riphagen, Ingrid Ingeborg; Martinussen, Marit; Jacobsen, Geir Wenberg (Journal article, 2017)
      Purpose of Review In this narrative review, we outline recent evidence relating longitudinal ultrasound (US) measurements to offspring outcomes in the perinatal period and in childhood, with an emphasis on the methodological ...

    • Longterm Outcomes of Temporomandibular Joints in Juvenile Idiopathic Arthritis: 17 Years of Followup of a Nordic Juvenile Idiopathic Arthritis Cohort. 

      Glerup, Mia; Stoustrup, Peter Bangsgaard; Matzen, Louise Hauge; Rypdal, Veronika Gjertsen; Nordal, Ellen Berit; Frid, Paula; Arnstad, Ellen Dalen; Rygg, Marite; Thorarensen, Olafur; Ekelund, Maria; Berntson, Lillemor; Fasth, Anders; Nilsson, H; Peltoniemi, Suvi; Aalto, Kristiina; Arte, Sirpa; Toftedal, Peter; Nielsen, Susan; Kreiborg, S.; Herlin, T; Pedersen, T. (Peer reviewed; Journal article, 2020)
      Objective. To determine the prevalence of orofacial symptoms, dysfunctions, and deformities of the temporomandibular joint (TMJ) in juvenile idiopathic arthritis (JIA) 17 years after disease onset. Methods. Drawn from ...

    • Loss of CpFTSY Reduces Photosynthetic Performance and Affects Insertion of PsaC of PSI in Diatoms 

      Nymark, Marianne; Finazzi, Giovanni; Volpe, Charlotte; Serif, Manuel Philipp; Fonseca, Davi de Miranda; Sharma, Animesh; Sanchez Puerto, Nicolas; Sharma, Amit Kumar; Ashcroft, Felicity Jayne; Kissen, Ralph; Winge, Per; Bones, Atle Magnar (Peer reviewed; Journal article, 2023)
      The chloroplast signal recognition particle (CpSRP) receptor (CpFTSY) is a component of the CpSRP pathway that post-translationally targets light-harvesting complex proteins (LHCPs) to the thylakoid membranes in plants and ...

    • Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity 

      Hotz, Adriana L.; Jamali, Ahmed; Rieser, Nicolas N.; Niklaus, Stephanie; Aydin, Ecem; Myren-Svelstad, Sverre; Lalla, Laetitia Noelle Patricia; Jurisch-Yaksi, Nathalie; Yaksi, Emre; Neuhauss, Stephan C.F. (Peer reviewed; Journal article, 2021)
      Astroglial excitatory amino acid transporter 2 (EAAT2, GLT-1, and SLC1A2) regulates the duration and extent of neuronal excitation by removing glutamate from the synaptic cleft. Hence, an impairment in EAAT2 function could ...

    • Loss of Mediator complex subunit 13 (MED13) promotes resistance to alkylation through cyclin D1 upregulation 

      Rolinski, Milosz; Montaldo, Nicola Pietro; Aksu, Merdane Ezgi; Martin, Sarah Fordyce; Brambilla, Alessandro; Kunath, Nicolas; Johansen, Jostein; Erlandsen, Sten Even; Liabakk, Nina-Beate; Rian, Kristin; Bjørås, Magnar; Sætrom, Pål; van Loon, Barbara (Peer reviewed; Journal article, 2020)
      Alkylating drugs are among the most often used chemotherapeutics. While cancer cells frequently develop resistance to alkylation treatments, detailed understanding of mechanisms that lead to the resistance is limited. Here, ...

    • A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment 

      Lin, Xiaolin; Wang, Wei; Yang, Mingyi; Damseh, Nadirah; Sousa, Mirta; Jacob, Fadi; lång, anna ulrika; Kristiansen, Elise; Pannone, Marco; Kissova, Miroslava; Almaas, Runar; Kusnierczyk, Anna; Siller, Richard; Shahrour, Maher; Al-Ashhab, Motee; Abu-Libdeh, Bassam; Tang, Wannan; Slupphaug, Geir; Elpeleg, Orly; Bøe, Stig Ove; Eide, Lars; Sullivan, Gareth John; Rinholm, Johanne Egge; Song, Hongjun; Ming, Guo-li; van Loon, Barbara; Edvardson, Simon; Ye, Jing; Bjørås, Magnar (Peer reviewed; Journal article, 2023)
      Background Oxidation Resistance 1 (OXR1) gene is a highly conserved gene of the TLDc domain-containing family. OXR1 is involved in fundamental biological and cellular processes, including DNA damage response, antioxidant ...

    • Low C-peptide together with a high glutamic acid decarboxylase autoantibody level predicts progression to insulin dependence in latent autoimmune diabetes in adults: The HUNT study 

      Sørgjerd, Elin P.; Åsvold, Bjørn O.; Grill, Valdemar (Journal article; Peer reviewed, 2021)
      Aim: To search for risk factors that could predict progression in latent autoimmune diabetes in adults (LADA) and compare them with those for type 2 diabetes. Materials and Methods: This study included 175 participants ...

    • Low expression levels of ATM may substitute for CHEK2/TP53 mutations predicting resistance towards anthracycline and mitomycin chemotherapy in breast cancer 

      Knappskog, Stian; Chrisanthar, Ranjan; Løkkevik, Erik; Anker, Gun Birgitta; Østenstad, Bjørn; Lundgren, Steinar; Risberg, Terje; Mjaaland, Ingvil; Leirvaag, Beryl; Miletic, Hrvoje; Lønning, Per Eystein (Journal article; Peer reviewed, 2012)
      Introduction Mutations affecting p53 or its upstream activator Chk2 are associated with resistance to DNA-damaging chemotherapy in breast cancer. ATM (Ataxia Telangiectasia Mutated protein) is the key activator of p53 ...

    • Low fat, low lactose diet used as prophylactic treatment of acute intestinal reactions during pelvic radiotherapy. A prospective randomised study 

      Bye, Asta (Dissertations at the Faculty of Medicine, 0805-7680; 203, Doctoral thesis, 2002)
      Purpose. The main aim of the present study was to evaluate the effect of a low fat, low lactose diet on acute and late gastrointestinal side effects of pelvic radiotherapy. We also wanted to evaluate if such a treatment ...