Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 1856-1875 av 3426
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Lipocalin 2 imparts selective pressure on bacterial growth in the bladder and is elevated in women with urinary tract infection
(Journal article; Peer reviewed, 2014)Competition for iron is a critical component of successful bacterial infections, but the underlying in vivo mechanisms are poorly understood. We have previously demonstrated that lipocalin 2 (LCN2) is an innate immunity ... -
Lipocalin 2 is expressed in MLO-Y4 osteocytes and regulated by the peroxisome proliferator activated receptor α agonist fenofibrate.
(Master thesis, 2020)Background: Lipocalin 2 is highly expressed and secreted from osteoblasts in mice. Lately, bone-derived lipocalin 2 has been shown to suppress appetite by binding to the MC4R in hypothalamus. In the present study we wanted ... -
Liposomes - Human phagocytes interplay in whole blood: effect of liposome design
(Journal article; Peer reviewed, 2023)Nanomedicine holds immense potential for therapeutic manipulation of phagocytic immune cells. However, in vitro studies often fail to accurately translate to the complex in vivo environment. To address this gap, we employed ... -
Liquid Biopsies in Solid Cancers: Implementation in a Nordic Healthcare System
(Peer reviewed; Journal article, 2021)Liquid biopsies have emerged as a potential new diagnostic tool, providing detailed information relevant for characterization and treatment of solid cancers. We here present an overview of current evidence supporting the ... -
Liquid Biopsy in Organ Damage: small extracellular vesicle chip-based assessment of polytrauma
(Journal article; Peer reviewed, 2023)Background Despite major advances in medicine, blood-borne biomarkers are urgently needed to support decision-making, including polytrauma. Here, we assessed serum-derived extracellular vesicles (EVs) as potential markers ... -
Live born recipient of twin-twin transfusion syndrome with anomalous mitral arcade
(Peer reviewed; Journal article, 2019)We present a case report of anomalous mitral arcade in a live born former recipient of twin-twin transfusion syndrome. At 33+0 week of gestation fetal ultrasound demonstrated that she had a large mitral insufficiency, ... -
Liver Activation of Hepatocellular Nuclear Factor-4α by Small Activating RNA Rescues Dyslipidemia and Improves Metabolic Profile
(Peer reviewed; Journal article, 2020)Non-alcoholic fatty liver disease (NAFLD) culminates in insulin resistance and metabolic syndrome. Because there are no approved pharmacological treatment agents for non-alcoholic steatohepatitis (NASH) and NAFLD, different ... -
LncRNA MORT (ZNF667-AS1) in Cancer—Is There a Possible Role in Gynecological Malignancies?
(Peer reviewed; Journal article, 2021)Gynecological cancers (GCs) are currently among the major threats to female health. Moreover, there are different histologic subtypes of these cancers, which are defined as ‘rare’ due to an annual incidence of <6 per 100,000 ... -
Local Postoperative Graft Inflammation in Pancreas Transplant Patients With Early Graft Thrombosis
(Peer reviewed; Journal article, 2023)Background. Graft thrombosis is the main cause of early graft loss following pancreas transplantation, and is more frequent in pancreas transplant alone (PTA) compared with simultaneous pancreas-kidney (SPK) recipients. ... -
Localization of NG2 immunoreactive neuroglia cells in the rat locus coeruleus and their plasticity in response to stress
(Journal article; Peer reviewed, 2014)The locus coeruleus (LC) nucleus modulates adaptive behavioral responses to stress and dysregulation of LC neuronal activity is implicated in stress-induced mental illnesses. The LC is composed primarily of noradrenergic ... -
Lokal bruk av traneksamsyre som blødningsprofylakse
(Peer reviewed; Journal article, 2023) -
The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans
(Peer reviewed; Journal article, 2020)Long non-coding RNAs are important regulators of biological processes including immune responses. The immunoregulatory functions of lncRNAs have been revealed primarily in murine models with limited understanding of lncRNAs ... -
Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trial
(Peer reviewed; Journal article, 2020)Objective To determine whether risk adapted intraoperative radiotherapy, delivered as a single dose during lumpectomy, can effectively replace postoperative whole breast external beam radiotherapy for early breast ... -
Long term trends of breast cancer incidence according to proliferation status
(Peer reviewed; Journal article, 2022)Background Long-term breast cancer incidence trends according to proliferation status are poorly described. We studied time-trends in breast cancer incidence, using mitotic count and Ki-67 as markers of proliferation. ... -
Long-term consequences of prematurity: Motor skills, mental health, health-related quality of life and white matter microstructure in young adults born preterm with very low birth weight
(Doctoral theses at NTNU;2017:207, Doctoral thesis, 2017)LANGTIDSKONSEKVENSER AV FOR TIDLIG FØDSEL Motoriske ferdigheter, psykisk helse, livskvalitet og integritet av hjernens hvite substans hos unge voksne født for tidlig med veldig lav fødselsvekt Barn som er født for ... -
Long-Term Exposure to Nanosized TiO2 Triggers Stress Responses and Cell Death Pathways in Pulmonary Epithelial Cells
(Peer reviewed; Journal article, 2021)There is little in vitro data available on long-term effects of TiO2 exposure. Such data are important for improving the understanding of underlying mechanisms of adverse health effects of TiO2 . Here, we exposed pulmonary ... -
Long-term follow-up of mental health, health-related quality of life and associations with motor skills in young adults born preterm with very low birth weight
(Journal article; Peer reviewed, 2016)Background: Being born with very low birth weight(VLBW:≤1500 g) is related to long-term disability and neurodevelopmental problems, possibly affecting mental health and health-related quality of life (HRQoL). However, ... -
Long-Term Incidence of Venous Thromboembolism in Cancer: The Scandinavian Thrombosis and Cancer Cohort
(Journal article; Peer reviewed, 2018)The risk of venous thromboembolism (VTE) in patients who survive the first years after a cancer diagnosis after the acute effects of disease and treatment in comparison to a similar background population has been sparsely ... -
Long-term motor outcomes of very preterm and/or very low birth weight individuals without cerebral palsy: A review of the current evidence
(Peer reviewed; Journal article, 2020)We reviewed literature on long-term motor outcomes of individuals aged five years or older born very preterm (VP: ≤32 weeks of gestation) or with very low birth weight (VLBW: ≤1500g), without cerebral palsy (CP). PubMed ...