Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 1362-1381 of 1899
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Prognostic role of microscopically positive margins for primary gastrointestinal stromal tumors: a systematic review and meta-analysis
(Peer reviewed; Journal article, 2016)The impact and management of microscopically positive margins in gastrointestinal stromal tumors (GISTs) remain unclear. The aim of this study is to estimate the prognostic value of surgical margins for disease-free survival ... -
Prognostic value of ErbB2/HER2 in human meningiomas
(Journal article; Peer reviewed, 2018)Introduction Among clinical challenges regarding human meningiomas is their propensity to recur even in cases with benign histology. Reliable biomarkers that can identify these cases are therefore highly desired. ErbB2/HER2 ... -
Prognostic value of Ki-67/MIB-1 labeling index in human meningiomas - a review of theliterature
(Master thesis, 2009) -
Prognostic value of metabolic response in breast cancer patients receiving neoadjuvant chemotherapy
(Journal article; Peer reviewed, 2012)Background Today's clinical diagnostic tools are insufficient for giving accurate prognosis to breast cancer patients. The aim of our study was to examine the tumor metabolic changes in patients with locally advanced breast ... -
Progressive multifocal leukoencephalopathy in an immunocompetent patient?
(Peer reviewed; Journal article, 2013)Background: Progressive multifocal leukoencephalopathy (PML) is a rapidly progressive, potentially fatal, demyelinating disease affecting immunosuppressed patients. PML is rarely reported in cases with no underlying disease ... -
Prolactin and breast increase during pregnancy in PCOS: linked to long-term metabolic health?
(Journal article; Peer reviewed, 2019)Objective To explore whether gestational prolactin and breast increase are markers of metabolic health in pregnancy and on long-term, in PCOS. Design Follow-up study. Women with PCOS, according to the Rotterdam criteria ... -
Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells
(Journal article; Peer reviewed, 2013)Background Cigarette smoking is the major risk factor for COPD, leading to chronic airway inflammation. We hypothesized that cigarette smoke induces structural and functional changes of airway epithelial mitochondria, ... -
Properdin binding to complement activating surfaces depends on initial C3b deposition
(Journal article; Peer reviewed, 2017)Two functions have been assigned to properdin; stabilization of the alternative convertase, C3bBb, is well accepted, whereas the role of properdin as pattern recognition molecule is controversial. The presence of ... -
Prospective longitudinal MRI study of brain volumes and diffusion changes during the first year after moderate to severe traumatic brain injury
(Journal article, 2014)The objectives of this prospective study in 62 moderate–severe TBI patients were to investigate volume change in cortical gray matter (GM), hippocampus, lenticular nucleus, lobar white matter (WM), brainstem and ventricles ... -
Prostate Cancer – Translational Research: Optimizing tissue sampling suitable for histopathologic, transcriptomic and metabolic profiling
(Doktoravhandlinger ved NTNU, 1503-8181; 2012:240, Doctoral thesis, 2012)Prostate cancer (PCa) is the most common cancer in men in Europe and constitutes a substantial health care problem. In 2009, 4299 new cases were diagnosed in Norway and PCa was the second most common cause of death from ... -
Prostate-Specific Membrane Antigen PET/Magnetic Resonance Imaging for the Planning of Salvage Radiotherapy in Patients with Prostate Cancer with Biochemical Recurrence After Radical Prostatectomy
(Journal article; Peer reviewed, 2019)Prostate-specific membrane antigen (PSMA) PET/magnetic resonance (MR) imaging can help distinguish between patients with prostate cancer with locoregional recurrence and those with distant metastases, even at low ... -
Protect us from ourselves: Balancing the parental instinct of saving
(Peer reviewed; Journal article, 2019)Background: Neonatologists, legal experts and ethicists extensively discuss the ethical challenges of decision-making when a child is born at the limit of viability. The voices of parents are less heard in this discussion. ... -
Protein-protein interactions of the nuclear receprot NR4A2
(Master thesis, 2014)The Gastroenterology and Molecular cell biology research group examines biological mechanisms that are important in the development of gastric cancer. The peptide hormone gastrin is known to play a role in organization ... -
Proteogenomic Analysis to Identify Missing Proteins from Haploid Cell Lines
(Journal article, 2018)Chromosome-centric Human Proteome Project aims at identifying and characterizing protein products encoded from all human protein-coding genes. As of early 2017, 19,837 protein-coding genes have been annotated in the neXtProt ... -
Proteomic approaches to improve cancer therapy – Identifying factors contributing to melphalan resistance in multiple myeloma and to PDT mediated cytotoxicity
(Doktoravhandlinger ved NTNU, 1503-8181; 2014:147, Doctoral thesis, 2014) -
Proteomics Analysis of Proteins Involved in DNA Base Repair and Cancer Therapy
(Doktoravhandlinger ved NTNU, 1503-8181; 2012:72, Doctoral thesis, 2012)Proteomikkbasert analyse av proteiner involvert i DNA reparasjon og kreftbehandling DNA reparasjon er grunnleggende for å opprettholdelse levende organismers genom. Forskning i løpet av det siste tiåret har vesentlig økt ... -
Proton pump inhibitors and fracture risk. The HUNT study, Norway.
(Journal article; Peer reviewed, 2019)Summary Proton pump inhibitors (PPIs) have been linked to increased risk of fracture; the data have, however, been diverging. We did not find any increased risk of fractures among users of PPIs in a Norwegian population ... -
Protozoan ALKBH8 Oxygenases Display both DNA Repair and tRNA Modification Activities
(Journal article; Peer reviewed, 2014)The ALKBH family of Fe(II) and 2-oxoglutarate dependent oxygenases comprises enzymes that display sequence homology to AlkB from E. coli, a DNA repair enzyme that uses an oxidative mechanism to dealkylate methyl and etheno ... -
Pseudo-anaphylaxis to polyethylene glycol (PEG)-coated liposomes: Roles of anti-PEG IgM and complement activation in a porcine model of human infusion reactions
(Journal article; Peer reviewed, 2019)Polyethylene glycol (PEG)-coated nanopharmaceuticals can cause mild to severe hypersensitivity reactions (HSRs), which can occasionally be life threatening or even lethal. The phenomenon represents an unsolved immune barrier ...