Now showing items 2126-2145 of 3415

    • N-3 Polyunsaturated Fatty Acids in Health and Disease - Clinical and Molecular Aspects 

      Slagsvold, Jens Erik (Doktoravhandlinger ved NTNU, 1503-8181; 2009:119, Doctoral thesis, 2009)
        Omega-3 Flerumettede Fettsyrer og Helse – Kliniske og Molekylære Aspekter Omega-3 fettsyrer tilhører gruppen essensielle fettsyrer. Det betyr at vi ikke kan lage dem selv, men at de må tilføres gjennom kosten, ...
    • N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2 

      Mildenberger, Jennifer; Johansson, Ida; Sergin, Ismail; Kjøbli, Eli; Damås, Jan Kristian; Razani, Babak; Flo, Trude Helen; Bjørkøy, Geir (Journal article; Peer reviewed, 2017)
      Inflammation is crucial in the defense against infections but must be tightly controlled to limit detrimental hyperactivation. Our diet influences inflammatory processes and omega-3 polyunsaturated fatty acids (n-3 PUFAs) ...
    • N6-Acetyl-L-Lysine and p-Cresol as Key Metabolites in the Pathogenesis of COVID-19 in Obese Patients 

      Jalaleddine, Nour; Hachim, Mahmood; Al-Hroub, Hamza; Saheb Sharif-Askari, Narjes; Senok, Abiola; Elmoselhi, Adel; Mahboub, Bassam; Samuel Kurien, Nimmi Moni; Kandasamy, Richard Kumaran; Semreen, Mohammad H.; Halwani, Rabih; Soares, Nelson C.; Al Heialy, Saba (Peer reviewed; Journal article, 2022)
      Despite the growing number of the vaccinated population, COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a global health burden. Obesity, a metabolic syndrome affecting one-third ...
    • N6-methyladenosine in RNA of atherosclerotic plaques: An epitranscriptomic signature of human carotid atherosclerosis 

      Quiles Jimenez, Ana Maria Teresa; Gregersen, Ida; Sousa, Mirta; Abbas, Azhar; Kong, Xiang Yi; Alseth, Ingrun; Holm, Sverre; Dahl, Tuva Børresdatter; Skagen, Karolina Ryeng; Skjelland, Mona; Aukrust, Pål; Bjørås, Magnar; Halvorsen, Bente (Peer reviewed; Journal article, 2020)
      Background More than 170 post-transcriptional RNA modifications regulate the localization, processing and function of cellular RNAs, and aberrant RNA modifications have been linked to a range of human diseases. The RNA ...
    • Nafamostat–interferon-α combination suppresses sars-cov-2 infection in vitro and in vivo by cooperatively targeting host TMPRSS2 

      Ianevski, Aleksandr; Yao, Rouan; Lysvand, Hilde; Grødeland, Gunnveig; Legrand, Nicolas; Oksenych, Valentyn; Zusinaite, Eva; Tenson, Tanel; Bjørås, Magnar; Kainov, Denis E. (Peer reviewed; Journal article, 2021)
      SARS-CoV-2 and its vaccine/immune-escaping variants continue to pose a serious threat to public health due to a paucity of effective, rapidly deployable, and widely available treatments. Here, we address these challenges ...
    • Nanomaterials - Toxic or Therapeutic? 

      Behsen, Alenka Djarmila (Master thesis, 2020)
      Nanomaterialer (NMer), slik som nedbrytningsprodukter av plast og konstruerte medikament leveringspartikler, både slippes ut i miljøet og administreres til mennesker i økende grad. Dette gjør at man stiller spørsmål ved ...
    • Nanoparticle Mediated P-Glycoprotein Silencing for Improved Drug Delivery across the Blood-Brain Barrier: A siRNA-Chitosan Approach 

      Malmo, Jostein; Sandvig, Axel; Vårum, Kjell Morten; Strand, Sabina P. (Journal article; Peer reviewed, 2013)
      Background: Neonatal intermittent hyperoxia-hypoxia (IHH) is involved in the pathogenesis of retinopathy of prematurity. Whether similar oxygen fluctuations will create pathological changes in the grey and white matter ...
    • Nanoplastics - A Potential Threat To Human Health? 

      Solhaug, Helene (Master thesis, 2019)
      Den økende bruken av nanomaterialer i alt fra forbruksprodukter til medisiner har ført til en økende offentlig interesse for hvilke følger eksponeringen kan ha for mennesker og helse. Det å forstå hvilke inflammatoriske ...
    • Nanoplastics affect the inflammatory cytokine release by primary human monocytes and dendritic cells 

      Weber, Annkatrin; Schwiebs, Anja; Solhaug, Helene; Stenvik, Jørgen; Nilsen, Asbjørn Magne; Wagner, Martin; Relja, Borna; Radeke, Heinfried H. (Peer reviewed; Journal article, 2022)
      So far, the human health impacts of nano- and microplastics are poorly understood. Thus, we investigated whether nanoplastics exposure induces inflammatory processes in primary human monocytes and monocyte-derived dendritic ...
    • A national intercalated medical student research program–student perceptions, satisfaction, and factors associated with pursuing a PhD 

      Sandvei, Marie Søfteland; Jacobsen, Geir Wenberg; Stien, Marianne Heldal; Ræder, Helge; Munthe, Ludvig Andre; Skogen, Vegard (Peer reviewed; Journal article, 2022)
      Background To counteract a decreasing number of physician-scientists, a national intercalated Medical Student Research Programme (MSRP) was launched in Norway in 2002. We aimed to assess whether the students’ favourable ...
    • National prospective cohort study of the burden of acute small bowel obstruction 

      NASBO, NASBO Collaborators; Bolkan, Håkon Angell (Journal article; Peer reviewed, 2019)
      Background Small bowel obstruction is a common surgical emergency, and is associated with high levels of morbidity and mortality across the world. The literature provides little information on the conservatively managed ...
    • Naturally occurring phenethyl isothiocyanate-induced inhibition of gastric cancer cell growth by disruption of microtubules 

      Øverby, Anders; Zhao, Chun-Mei; Bones, Atle M.; Chen, Duan (Journal article; Peer reviewed, 2014)
      Abstract Background and Aim Phenethyl isothiocyanate (PEITC) derives from vegetables commonly consumed by man and has been demonstrated as a promising chemopreventive agent against several types of cancer. However, the ...
    • NAxtra magnetic nanoparticles for low-cost, efficient isolation of mammalian DNA and RNA 

      Starheim, Eirin Johannessen; Ravlo, Erlend; Schjølberg, Jørn-Ove; Solvang, Vanessa; Wang, Wei; Scrimgeour, Nathan Robert; Manaf, Adeel; Erlandsen, Sten Even; Aas, Per Arne; Hagen, Lars; Sousa, Mirta; Bjørås, Magnar (Peer reviewed; Journal article, 2023)
      A cost-effective, viral nucleic acid (NA) isolation kit based on NAxtra magnetic nanoparticles was developed at the Norwegian University of Science and Technology in response to the shortage of commercial kits for isolation ...
    •  Ultrasound and labour 

      Eggebø, Torbjørn Moe (Doktoravhandlinger ved NTNU, 1503-8181; 2009:77, Doctoral thesis, 2009)
      2.1 Innledning  Alle kvinner ønsker seg en ukomplisert fødsel, men komplikasjoner kan oppstå plutselig og uventet. I følge Verdens Helseorganisasjon trenger 15% av de gravide kyndig hjelp under svangerskap eller ...
    • Nedregulering av urokinase ved hjelp av RNA-interferens 

      Hammervold, Kristen Kåre Rembar (Master thesis, 2009)
    • NEFA Dynamics in Adults With Severe Obesity and Insulin Resistance: No Coupling to the rs9939609 FTO Risk Allele 

      Mostad, Ingrid Løvold; Grill, Valdemar Erik Robert (Peer reviewed; Journal article, 2023)
      Context: The FTO gene is highly expressed in adipose tissues; however, whether nonesterified fatty acids (NEFA) dynamics are impacted by FTO has not been rigorously tested for in a uniformly obese study population comprising ...
    • NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice 

      Hildrestrand, Gunn Annette; Rolseth, Veslemøy; Kunath, Nicolas; Suganthan, Rajikala; Jensen, Vidar; Bugaj, Anna Maria; Fernandez Berrocal, Marion Silvana; SIkko, Sunniva Bøe; Vetlesen, Susanne; Kusnierczyk, Anna; Olsen, Ann-Karin Hardie; Gutzkow, Kristine Bjerve; Rowe, Alexander D.; Wang, Wei; Moldestad, Olve; Syrstad, Monika; Slupphaug, Geir; Eide, Lars; Klungland, Arne; Sætrom, Pål; Luna, Luisa; Ye, Jing; Scheffler, Katja; Bjørås, Magnar (Peer reviewed; Journal article, 2021)
      Oxidative DNA damage in the brain has been implicated in neurodegeneration and cognitive decline. DNA glycosylases initiate base excision repair (BER), the main pathway for oxidative DNA base lesion repair. NEIL1 and NEIL3 ...
    • Neil3 induced neurogenesis protects against prion disease during the clinical phase 

      Jalland, Clara Maria Osnes; Scheffler, Katja; Benestad, Sylvie Lafond; Moldal, Torfinn; Ersdal, Cecilie; Gunnes, Gjermund; Suganthan, Rajikala; Bjørås, Magnar; Tranulis, Michael A. (Journal article; Peer reviewed, 2016)
      Base excision repair (BER) is the major pathway for repair of oxidative DNA damage. Mice with genetic knockout of the BER enzyme Neil3 display compromised neurogenesis in the sub-ventricular zone of the lateral ventricle ...
    • NEIL3-deficiency increases gut permeability and contributes to a pro-atherogenic metabolic phenotype 

      Karlsen, Tom Rune; Kong, Xiang Yi; Holm, Sverre; Quiles-Jiménez, Ana M T; Dahl, Tuva Børresdatter; Yang, Kuan; Sagen, Ellen Lund; Skarpengland, Tonje; Øgaard, Jonas; Holm, Kristian; Vestad, Beate; Olsen, Maria Belland; Aukrust, Pål; Bjørås, Magnar; Hov, Johannes Espolin Roksund; Halvorsen, Bente; Gregersen, Ida (Journal article; Peer reviewed, 2021)
      Atherosclerosis and its consequences cause considerable morbidity and mortality world-wide. We have previously shown that expression of the DNA glycosylase NEIL3 is regulated in human atherosclerotic plaques, and that ...
    • NEIL3-deficient bone marrow displays decreased hematopoietic capacity and reduced telomere length 

      Karlsen, Tom Rune; Olsen, Maria Belland; Kong, Xiang Yi; Yang, Kuan; Quiles-Jiménez, Ana M T; Kroustallaki, Pinelopi; Holm, Sverre; Lines, Glenn Terje; Aukrust, Pål; Skarpengland, Tonje; Bjørås, Magnar; Dahl, Tuva Børresdatter; Nilsen, Hilde; Gregersen, Ida; Halvorsen, Bente (Peer reviewed; Journal article, 2022)
      Deficiency of NEIL3, a DNA repair enzyme, has significant impact on mouse physiology, including vascular biology and gut health, processes related to aging. Leukocyte telomere length (LTL) is suggested as a marker of ...