Browsing Institutt for klinisk og molekylær medisin by Title

Now showing items 1498-1517 of 3426

    • I jordmors hender - En kvalitativ studie om kvinners opplevelse av å føde på en jordmorstyrt enhet 

      Braseth, Kristin.; Auran, K, Linda. (Master thesis, 2022)
      Bakgrunnen for studien er at det sees en økende medikalisering innen den moderne fødselsomsorgen. Dette utgjør en risiko for økt forekomst av intervensjoner i fødselsforløpet, noe som kan ha påvirkning på hvilken opplevelse ...

    • I jordmors hender- En kvalitativ studie om kvinners opplevelse av å føde på en jordmorstyrt enhet 

      Auran, Linda Krakeli; Braseth, Kristin (Master thesis, 2022)
      Bakgrunnen for studien er at det sees en økende medikalisering innen den moderne fødselsomsorgen. Dette utgjør en risiko for økt forekomst av intervensjoner i fødselsforløpet, noe som kan ha påvirkning på hvilken opplevelse ...

    • Icotinib is an active treatment of non-small-cell lung cancer: A retrospective study 

      Chen, X; Zhu, Q; Liu, Y; Liu, P; Yin, Y; Guo, R; Lu, K; Gu, Y; Liu, L; Wang, J; Wang, Z; Røe, Oluf Dimitri; Shu, Y; Zhu, L (Journal article; Peer reviewed, 2014)
      Background Icotinib hydrochloride is a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with preclinical and clinical activity in non-small cell lung cancer (NSCLC). This retrospective ...

    • Identification and Tracking of Antiviral Drug Combinations 

      Ianevski, Aleksandr; Yao, Rouan; Biza, Svetlana; Zusinaite, Eva; Mannik, Andres; Kivi, Gaily; Planken, Anu; Kurg, Kristiina; Tombak, Eva-Maria; Ustav, Mart Jr; Shtaida, Nastassia; Kulesskiy, Evgeny; Jo, Eunji; Yang, Jaewon; Lysvand, Hilde; Løseth, Kirsti; Oksenych, Valentyn; Aas, Per Arne; Tenson, Tanel; Vitkauskienė, Astra; Windisch, Marc P; Fenstad, Mona H.; Nordbø, Svein Arne; Ustav, Mart; Bjørås, Magnar; Kainov, Denis (Peer reviewed; Journal article, 2020)
      Combination therapies have become a standard for the treatment for HIV and hepatitis C virus (HCV) infections. They are advantageous over monotherapies due to better efficacy, reduced toxicity, as well as the ability to ...

    • Identification of a regulatory pathway governing TRAF1 via an arthritis-associated non-coding variant 

      Wang, Qiang; Martínez-Bonet, Marta; Kim, Taehyeung; Sparks, Jeffrey A.; Ishigaki, Kazuyoshi; Chen, Xiaoting; Sudman, Marc; Aguiar, Vitor; Sim, Sangwan; Hernandez, Marcos Chiñas; Chiu, Darren J.; Wactor, Alexandra; Wauford, Brian; Marion, Miranda C.; Gutierrez-Arcelus, Maria; Bowes, John; Eyre, Stephen; Nordal, Ellen Berit; Prahalad, Sampath; Rygg, Marite; Videm, Vibeke; Raychaudhuri, Soumya; Weirauch, Matthew T.; Langefeld, Carl D.; Thompson, Susan D.; Nigrovic, Peter A. (Peer reviewed; Journal article, 2023)
      TRAF1/C5 was among the first loci shown to confer risk for inflammatory arthritis in the absence of an associated coding variant, but its genetic mechanism remains undefined. Using Immunochip data from 3,939 patients with ...

    • Identification of genes affecting alginate biosynthesis in Pseudomonas fluorescens by screening a transposon insertion library. 

      Ertesvåg, Helga; Sletta, Håvard; Senneset, Mona; Sun, Yi-Qian; Klinkenberg, Geir; Konradsen, Therese Aursand; Ellingsen, Trond E; Valla, Svein (Journal article; Peer reviewed, 2017)
      BACKGROUND: Polysaccharides often are necessary components of bacterial biofilms and capsules. Production of these biopolymers constitutes a drain on key components in the central carbon metabolism, but so far little is ...

    • Identification of genetic polymorphisms modulating nausea and vomiting in two series of opioid-treated cancer patients 

      Colombo, Francesca; Pintarelli, Giulia; Galvan, Antonella; Noci, Sara; Corli, Oscar; Skorpen, Frank; Klepstad, Pål; Kaasa, Stein; Pigni, Alessandra; Brunelli, Cinzia; Roberto, Anna; Piazza, Rocco; Pirola, Alessandra; Gambacorti-Passerini, Carlo; Caraceni, Augusto Tomasso Giovanni (Peer reviewed; Journal article, 2020)
      Nausea and vomiting are often associated with opioid analgesia in cancer patients; however, only a subset of patients develop such side effects. Here, we tested the hypothesis that the occurrence of nausea and vomiting is ...

    • Identification of Genetic Variation in Patients Suspicious of Lynch Syndrome Using Whole Exome Sequencing 

      Rosnes, Kristine (Master thesis, 2021)

    • Identification of Metabolites from 2D 1H-13C HSQC NMR using Peak Correlation Plots 

      Öman, Tommy; Tessem, May-Britt; Bathen, Tone Frost; Bertilsson, Helena; Angelsen, Anders; Hedenström, Mattias; Andreassen, Trygve (Journal article; Peer reviewed, 2014)
      Background Identification of individual components in complex mixtures is an important and sometimes daunting task in several research areas like metabolomics and natural product studies. NMR spectroscopy is an excellent ...

    • Identification of metastasis-associated microRNAs in serum from rectal cancer patients 

      Mjelle, Robin; Sellæg, Kjersti; Sætrom, Pål; Thommesen, Liv; Sjursen, Wenche; Hofsli, Eva (Peer reviewed; Journal article, 2017)
      MicroRNAs (miRNAs) are promising prognostic and diagnostic biomarkers due to their high stability in blood. Here we investigate the expression of miRNAs and other noncoding (nc) RNAs in serum of rectal cancer patients. ...

    • Identification of MicroRNA Expression in Gastrin Stimulated Adenocarcinoma Cells 

      Bergly, Laila H. (Master thesis, 2011)
      The Gastrin System Biology group studies the molecular responses to gastrin using cell line model systems. Recently microRNAs (miRNAs) have been acknowledged as essential participants in the regulation of gene expression, ...

    • Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma 

      Went, Molly; Sud, Amit; Försti, Asta; Halvarsson, Britt-Marie; Weinhold, Niels; Kimber, Scott; van Duin, Mark; Thorleifsson, Gudmar; Holroyd, Amy; Johnson, David C.; Li, Ni; Orlando, Giulia; Law, Philip J.; Ali, Mina; Chen, Bowang; Mitchell, Jonathan S.; Gudbjartsson, Daniel F.; Kuiper, Rowan; Stephens, Owen W.; Bertsch, Uta; Broderick, Peter; Campo, Chiara; Bandapalli, Obul R.; Einsele, Hermann; Gregory, Walter A.; Gullberg, Urban; Hillengass, Jens; Hoffmann, Per; Jackson, Graham H.; Jöckel, Karl-Heinz; Johnsson, Ellinor; Kristinsson, Sigurður Y.; Mellqvist, Ulf-Henrik; Nahi, Hareth; Easton, Douglas; Pharoah, Paul; Dunning, Alison; Peto, Julian; Canzian, Federico; Swerdlow, Anthony; Eeles, Rosalind A.; Kote-Jarai, ZSofia; Muir, Kenneth; Pashayan, Nora; Nickel, Jolanta; Nöthen, Markus M.; Rafnar, Thorunn; Ross, Fiona M.; da Silva Filho, Miguel Inacio; Thomsen, Hauke; Turesson, Ingemar; Vangsted, Annette; Andersen, Niels Frost; Waage, Anders; Walker, Brian A.; Wihlborg, Anna-Karin; Broyl, Annemiek; Davies, Faith E.; Thorsteinsdóttir, Unnur; Langer, Christian; Hansson, Markus; Goldschmidt, Hartmut; Kaiser, Martin; Sonneveld, Pieter; Stefansson, Kari; Morgan, Gareth J.; Hemminki, Kari; Nilsson, Björn; Houlston, Richard S. (Journal article; Peer reviewed, 2018)
      Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous ...

    • Identification of Novel Regulators of Epithelial Polarity and Cell Migration 

      Lobert, Viola Hélène (Doktoravhandlinger ved NTNU, 1503-8181; 2012:281, Doctoral thesis, 2012)
      The ability of cells to form separate apical and basolateral domains of their plasma membranes is an important aspect of epithelial integrity, and loss of epithelial polarity results in the acquisition of mesenchymal ...

    • Identification of the source of elevated hepatocyte growth factor levels in multiple myeloma patients 

      Rampa, Christoph Samuel; Tian, Erming; Våtsveen, Thea Kristin; Buene, Glenn; Slørdahl, Tobias Schmidt; Børset, Magne; Waage, Anders; Sundan, Anders (Journal article; Peer reviewed, 2014)
      Background Hepatocyte growth factor (HGF) is a pleiotropic cytokine which can lead to cancer cell proliferation, migration and metastasis. In multiple myeloma (MM) patients it is an abundant component of the bone marrow. ...

    • Identification of UCHL1 Binding Partners in Human Induced Pluripotent Stem Cell (hiPSC)-Derived Motor Neurons 

      Sæther, Anna Maria (Master thesis, 2022)
      Proper protein regulation is crucial for cell function. Ubiquitin is a 76 amino acid (aa) protein functioning as a post translational modification and thereby playing a central role in protein regulation. Ubiquitin (Ub) ...

    • Identification of unhealthy alcohol use by self-report and phosphatidylethanol (PEth) blood concentrations in an acute psychiatric department 

      Finanger, Trine; Vaaler, Arne; Spigset, Olav; Aamo, Trond Oskar; Andreassen, Trine Naalsund; Gråwe, Rolf W.; Skråstad, Ragnhild Bergene (Peer reviewed; Journal article, 2022)
      Background The use of standard screening methods could improve the detection rate of unhealthy alcohol use in patients admitted to psychiatric acute and emergency departments. The aim of the present study was to investigate ...

    • Identifying functional regulatory mutation blocks by integrating genome sequencing and transcriptome data 

      Yang, Mingyi; Ali, Omer; Bjørås, Magnar; Wang, Junbai (Peer reviewed; Journal article, 2023)
      Millions of single nucleotide variants (SNVs) exist in the human genome; however, it remains challenging to identify functional SNVs associated with diseases. We propose a non-encoding SNVs analysis tool bpb3, BayesPI-BAR ...

    • Identifying robust blood-based messenger RNA (mRNA) markers for potential detection of lung cancer: The Lung Cancer Biobank (NLCB) and the Nord-Trøndelag Health Study (HUNT) and Norwegian Women and Cancer Cohort (NOWAC) 

      Skogholt, Anne Heidi (Doctoral theses at NTNU;2021:310, Doctoral thesis, 2021)

    • Identifying small for gestational age preterm infants from the Finnish Medical Birth Register using eight growth charts 

      Hocquette, Alice; Pulakka, Anna; Metsälä, Johanna; Heikkilä, Katriina; Zeitlin, Jennifer; Kajantie, Eero Olavi (Peer reviewed; Journal article, 2022)

    • IFN-α with dasatinib broadens the immune repertoire in patients with chronic-phase chronic myeloid leukemia 

      Huuhtanen, Jani; Ilander, Mette; Yadav, Bhagwan; Dufva, Olli M.J.; Lähteenmäki, Hanna; Kasanen, Tiina; Klievink, Jay; Olsson-Strömberg, Ulla; Stentoft, Jesper; Richter, Johan; Koskenvesa, Perttu; Höglund, Martin; Söderlund, Stina; Dreimane, Arta; Porkka, Kimmo; Gedde-Dahl, Tobias; Gjertsen, Bjørn Tore; Stenke, Leif; Myhr-Eriksson, Kristina; Markevärn, Berit; Lübking, Anna; Dimitrijevic, Andreja; Udby, Lene; Bjerrum, Ole Weis; Hjorth-Hansen, Henrik; Mustjoki, Satu (Peer reviewed; Journal article, 2022)
      In chronic myeloid leukemia (CML), combination therapies with tyrosine kinase inhibitors (TKIs) aim to improve the achievement of deep molecular remission that would allow therapy discontinuation. IFN-α is one promising ...