Blar i Institutt for kjemi på forfatter "Øpstad, Christer Lorentz"

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    • Carotenoid Surfactants and Transfection Agents: The Colourful Chemistry of Polyenes 

      Øpstad, Christer Lorentz (Doktoravhandlinger ved NTNU, 1503-8181; 2010:87, Doctoral thesis, 2010)
      Synthetic procedures have been developed for efficient preparation of caroteinoid choline-ester analogues and phospholipids. One series of choline-esters and one series of phospholipids were based on β-apo-8’-carotenic ...

    • Cationic polyene phospholipids as DNA carriers for ocular gene therapy 

      Machado, Susana; Calado, Sofia; Bitoque, Diogo; Oliveira, Ana Vanessa; Øpstad, Christer Lorentz; Zeeshan, Muhammad; Sliwka, Hans-Richard; Partali, Vassilia; Pungente, Michael; Silva, Gabriela (Journal article; Peer reviewed, 2014)
      Recent success in the treatment of congenital blindness demonstrates the potential of ocular gene therapy as a therapeutic approach. The eye is a good target due to its small size, minimal diffusion of therapeutic agent ...

    • Novel cationic carotenoid lipids as delivery vectors of antisense oligonucleotides for exon skipping in duchenne muscular dystrophy 

      Popplewell, Linda; Abu-Dayya, Aseel; Khanna, Tushar; Flinterman, Marcella; Abdul Khalique, nada; Raju, Liji; Øpstad, Christer Lorentz; Sliwka, Hans-Richard; Partali, Vassilia; Dickson, George; Pungente, Michael (Journal article; Peer reviewed, 2012)
      Duchenne Muscular Dystrophy (DMD) is a common, inherited, incurable, fatal muscle wasting disease caused by deletions that disrupt the reading frame of the DMD gene such that no functional dystrophin protein is produced. ...

    • Synthesis and preliminary investigations of the siRNA delivery potential of novel, single-chain rigid cationic carotenoid lipids 

      Pungente, Michael; Jubeli, Emile; Øpstad, Christer Lorentz; Al-Kawaz, Mais; Barakat, Nour; Ibrahim, Tarek; Abdul Khalique, Nada; Raju, Liji; Jones, Rachel; Leopold, Philip; Sliwka, Hans-Richard; Partali, Vassilia (Journal article; Peer reviewed, 2012)
      The success of nucleic acid delivery requires the development of safe and efficient delivery vectors that overcome cellular barriers for effective transport. Herein we describe the synthesis of a series of novel, ...