Blar i Institutt for fysikk på forfatter "Zako, Tamotsu"

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    • Degradation of insulin amyloid by antibiotic minocycline and formation of toxic intermediates 

      Mori, Wakako; Yuzu, Keisuke; Lobsiger, Nadine; Nishioka, Hideo; Sato, Hisako; Nagase, Terumasa; Iwaya, Keiichi; Lindgren, Mikael; Zako, Tamotsu (Peer reviewed; Journal article, 2021)
      Insulin balls, localized insulin amyloids formed at subcutaneous insulin-injection sites in patients with diabetes, cause poor glycemic control owing to impairments in insulin absorption. Our previous study has shown that ...

    • Insulin amyloid polymorphs: implications for iatrogenic cytotoxicity† 

      Yuzu, Keisuke; Lindgren, Mikael; Nyström, Sofie; Zhang, Jun; Mori, Wakako; Kunitomi, Risako; Nagase, Terumasa; Iwaya, Keiichi; Hammarström, Per; Zako, Tamotsu (Peer reviewed; Journal article, 2020)
      Amyloid specific fluorescent probes are becoming an important tool for studies of disease progression and conformational polymorphisms in diseases related to protein misfolding and aggregation such as localized and systemic ...

    • Nanoscopic and Photonic Ultrastructural Characterization of Two Distinct Insulin Amyloid States 

      Psonka-Antonczyk, Katarzyna Maria; Duboisset, Julien; Stokke, Bjørn Torger; Zako, Tamotsu; Kobayashi, Takahiro; Maeda, Mizuo; Nyström, Sofie; Mason, Jeffrey; Hammarström, Per; Nilsson, K. Peter R.; Lindgren, Mikael (Journal article; Peer reviewed, 2012)
      Two different conformational isoforms or amyloid strains of insulin with different cytotoxic capacity have been described previously. Herein these filamentous and fibrillar amyloid states of insulin were investigated using ...