Blar i Institutt for fysikk på forfatter "Gederaas, Odrun Arna"
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Amphiphilic Protoporphyrin IX Derivatives as New Photosensitizing Agents for the Improvement of Photodynamic Therapy
Desgranges, Stéphane; Juzenas, Petras; Vasovic, Vlada; Gederaas, Odrun Arna; Lindgren, Mikael; Warloe, Trond; Qian, Peng; Contino-Pepin, Christiane (Peer reviewed; Journal article, 2022)Photodynamic therapy (PDT) is a non-invasive therapeutic modality based on the interaction between a photosensitive molecule called photosensitizer (PS) and visible light irradiation in the presence of oxygen molecule. ... -
Influence of Polymer Charge on the Localization and Dark- and Photo-Induced Toxicity of a Potential Type I Photosensitizer in Cancer Cell Models
Lindgren, Mikael; Gederaas, Odrun Arna; Siksjø, Monica; Hansen, Tom Andre; Chen, Lena; Mettra, Bastien; Andraud, Chantal; Monnereau, Cyrille (Peer reviewed; Journal article, 2020)A current trend within photo-dynamic therapy (PDT) is the development of molecular systems targeting hypoxic tumors. Thus, type I PDT sensitizers could here overcome traditional type II molecular systems that rely on the ... -
Photodynamic Therapy with Novel Glycosylated Chlorin Complexes on Bladder Cancer Cells from Rat (AY-27) and Human (T-24)
Hageberg, Ingvild Uri (Master thesis, 2021)Formålet med dette masterprosjektet var å utforske fotodynamiske, fotofysiske og fotokjemiske egenskaper til noen nye glykosylerte kloriner. Dette prosjektet er en del av et pågående samarbeid mellom Institutt for fysikk, ... -
Photosensitizing Effects of Novel Glycosylated Chlorin Complexes on the AY-27 Cancer Cell Model
Vindstad, Benedikte Emilie (Master thesis, 2020)Målet for dette prosjektet var å finne potensialet til KA20-familien av glykosylerte kloriner som fotosensibiliserende forbindelser i fotodynamisk terapi (PDT) av kreftsykdom. Kreft er en av verdens ledende dødsårsaker. ... -
Red versus blue light illumination in hexyl 5-aminolevulinate photodynamic therapy: the influence of light color and irradiance on the treatment outcome in vitro
Helander, Linda; Krokan, Hans Einar; Johnsson, Anders Carl G.; Gederaas, Odrun Arna; Plaetzer, Kristjan (Journal article; Peer reviewed, 2014)Abstract. Hexyl 5-aminolevulinate (HAL) is a lipophilic derivative of 5-aminolevulinate, a key intermediate in biosynthesis of the photosensitizer protoporphyrin IX (PpIX). The photodynamic efficacy and cell death mode ... -
Synthesis and in vitro evaluation of a novel thienopyrimidine with phototoxicity towards rat glioma F98 cells
Gederaas, Odrun Arna; Sørensen, Andreas S.; Lindgren, Mikael; Melø, Thor Bernt; Altin, Dag; Flatby, Ellen M. Samdahl; Høgset, Anders; Hoff, Bård Helge (Peer reviewed; Journal article, 2022)Glioblastoma multiforme is one of the most aggressive cancer forms in humans, and has low recovery rates after surgery, ionizing radiation and chemotherapy. Therefore, there is a high interest in the development of new ...