• The circulating soluble form of the CD40 costimulatory immune checkpoint receptor and liver metastasis risk in rectal cancer 

      Meltzer, Sebastian; Kristensen, Annette Torgunrud; Abrahamsson, Hanna Josefine; Solbakken, Arne Mide; Flatmark, Kjersti; Dueland, Svein; Bakke, Kine Mari; Bousquet, Paula; Negård, Anne; Johansen, Christin; Lyckander, Lars Gustav; Larsen, Finn Ole; Schou, Jakob Vasehus; Redalen, Kathrine; Ree, Anne Hansen (Peer reviewed; Journal article, 2021)
      Background In colorectal cancer, the inflamed tumour microenvironment with its angiogenic activities is immune- tolerant and incites progression to liver metastasis. We hypothesised that angiogenic and inflammatory factors ...
    • Comparison of Intravoxel incoherent motion imaging and multiecho dynamic contrast-based MRI in rectal cancer 

      Bakke, Kine Mari; Grøvik, Endre; Meltzer, Sebastian; Negård, Anne; Holmedal, Stein Harald; Mikalsen, Lars Tore G; Lyckander, Lars Gustav; Ree, Anne Hansen; Gjesdal, Kjell-Inge; Redalen, Kathrine; Bjørnerud, Atle (Journal article; Peer reviewed, 2019)
      Background Dynamic contrast‐based MRI and intravoxel incoherent motion imaging (IVIM) MRI are both methods showing promise as diagnostic and prognostic tools in rectal cancer. Both methods aim at measuring perfusion‐related ...
    • Diffusion-weighted magnetic resonance imaging of rectal cancer: tumour volume and perfusion fraction predict chemoradiotherapy response and survival 

      Bakke, Kine Mari; Hole, Knut Håkon; Dueland, Svein; Kotanska-Grøholt, Krystyna; Flatmark, Kjersti; Ree, Anne Hansen; Seierstad, Therese; Redalen, Kathrine Røe (Journal article, 2017)
      Background: In locally advanced rectal cancer (LARC), responses to preoperative treatment are highly heterogeneous and more accurate diagnostics are likely to enable more individualised treatment approaches with improved ...
    • Imaging the tumour microenvironment in rectal cancer: Decline in tumour blood flow during radiotherapy predicts good outcome 

      Bakke, Kine Mari; Meltzer, Sebastian; Grøvik, Endre; Negård, Anne; Holmedal, Stein Harald; Mikalsen, Lars Tore Gyland; Færden, Arne Engebreth; Lyckander, Lars Gustav; Julbø, Frida Marie Ihle; Bjørnerud, Atle; Gjesdal, Kjell Inge; Ree, Anne Hansen; Redalen, Kathrine Røe (Peer reviewed; Journal article, 2023)
      Background and purpose Measuring rectal tumour response to radiation is pivotal to restaging patients and for possibly stratification to a watch-and-wait strategy. Recognizing the importance of the tumour microenvironment, ...
    • Semi-automatic tumor segmentation of rectal cancer based on functional magnetic resonance imaging 

      Knuth, Franziska Hanna; Grøndahl, Aurora Rosvoll; Winter, René; Torheim, Turid Katrine Gjerstad; Negård, Anne; Holmedal, Stein Harald; Bakke, Kine Mari; Meltzer, Sebastian; Futsæther, Cecilia Marie; Redalen, Kathrine (Peer reviewed; Journal article, 2022)
      Background and purpose Tumor delineation is required both for radiotherapy planning and quantitative imaging biomarker purposes. It is a manual, time- and labor-intensive process prone to inter- and intraobserver ...
    • Sex differences and tumor blood flow from dynamic susceptibility contrast MRI are associated with treatment response after chemoradiation and long-term survival in rectal cancer 

      Bakke, Kine Mari; Meltzer, Sebastian; Grøvik, Endre; Negård, Anne; Holmedal, Stein Harald; Gjesdal, Kjell-Inge; Bjørnerud, Atle; Ree, Anne Hansen; Redalen, Kathrine (Peer reviewed; Journal article, 2020)
      Sex differences, tumor vascularity, and blood flow seen on multiecho dynamic contrast–based MRI scans enabled prediction of treatment response and overall survival in patients with rectal cancer. Background: MRI is the ...
    • Sex-related differences in primary metastatic site in rectal cancer; associated with hemodynamic factors? 

      Meltzer, Sebastian; Bakke, Kine Mari; Rød, Karina Lund; Negård, Anne; Flatmark, Kjersti; Solbakken, Arne Mide; Kristensen, Annette Torgunrud; Fuglestad, Anniken Jørlo; Kersten, Christian; Dueland, Svein; Seierstad, Therese; Hole, Knut Håkon; Lyckander, Lars Gustav; Larsen, Finn Ole; Schou, Jakob Vasehus; Brown, Dawn; Abrahamsson, Hanna Josefine; Redalen, Kathrine; Ree, Anne Hansen (Journal article; Peer reviewed, 2019)
      Background and purpose We investigated how features relating to pelvic cavity anatomy and tumor hemodynamic factors may influence systemic failure in rectal cancer. Materials and methods Rectal cancer patients (207 ...