• ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine 

      Fontana, Diletta; Mauri, Mario; Renso, Rossella; Docci, Mattia; Crespiatico, Ilaria; Røst, Lisa Marie; Jang, Mi; Niro, Antonio; D’Aliberti, Deborah; Massimino, Luca; Bertagna, Mayla; Zambrotta, Giovanni; Bossi, Mario; Citterio, Stefania; Crescenzi, Barbara; Fanelli, Francesca; Cassina, Valeria; Corti, Roberta; Salerno, Domenico; Nardo, Luca; Chinello, Clizia; Mantegazza, Francesco; Mecucci, Cristina; Magni, Fulvio; Cavaletti, Guido; Bruheim, Per; Larsen, Steen; Rea, Delphine; Gambacorti-Passerini, Carlo; Piazza, Rocco (Peer reviewed; Journal article, 2020)
      Recurrent somatic mutations in ETNK1 (Ethanolamine-Kinase-1) were identified in several myeloid malignancies and are responsible for a reduced enzymatic activity. Here, we demonstrate in primary leukemic cells and in cell ...
    • The genomic basis of the plant island syndrome in Darwin’s giant daisies 

      Cerca, José; Petersen, Bent; Lazaro-Guevara, José Miguel; Rivera-Colón, Angel G.; Birkeland, Siri; Vizueta, Joel; Li, Siyu; Li, Qionghou; Loureiro, João; Kosawang, Chatchai; Jaramillo Díaz, Patricia; Rivas-Torres, Gonzalo; Fernández-Mazuecos, Mario; Vargas, Pablo; McCauley, Ross; Petersen, Gitte; Santos-Bay, Luisa; Wales, Nathan; Catchen, Julian M.; Machado, Daniel; Nowak, Michael; Suh, Alexander; Sinha, Neelima R.; Rostgaard Nielsen, Lene; Seberg, Ole; Gilbert, Marcus Thomas Pius; Leebens-Mack, James H.; Rieseberg, Loren H.; Martin, Michael David (Peer reviewed; Journal article, 2022)
      The repeated, rapid and often pronounced patterns of evolutionary divergence observed in insular plants, or the ‘plant island syndrome’, include changes in leaf phenotypes, growth, as well as the acquisition of a perennial ...
    • The Seminavis Robusta Genome Provides Insights Into the Evolutionary Adaptations of Benthic Diatoms 

      Osuna-Cruz, Cristina Maria; Bilcke, Gust; Vancaester, Emmelien; De Decker, Sam; Bones, Atle M.; Winge, Per; Poulsen, Nicole; Bulankova, Petra; Verhelst, Bram; Audoor, Sien; Belisova, Darja; Pargana, Aikaterini; Russo, Monica; Stock, Frederike; Cirri, Emilio; Brembu, Tore; Pohnert, Georg; Piganeau, Gwenael; Ferrante, Maria I; Mock, Thomas; Sterck, Lieven; Sabbe, Koen; De Veylder, Lieven; Vyverman, Wim; Vandepoele, Klaas (Peer reviewed; Journal article, 2020)
      Benthic diatoms are the main primary producers in shallow freshwater and coastal environments, fulfilling important ecological functions such as nutrient cycling and sediment stabilization. However, little is known about ...
    • Visible light-exposed lignin facilitates cellulose solubilization by lytic polysaccharide monooxygenases 

      Kommedal, Eirik; Angeltveit, Camilla Fløien; Klau, Leesa Jane; Ayuso-Fernandez, Ivan; Arstad, Bjørnar; Antonsen, Simen; Stenstrøm, Yngve; Ekeberg, Dag; Gírio, Francisco; Carvalheiro, Florbela; Horn, Svein Jarle; Aachmann, Finn Lillelund; Eijsink, Vincent (Peer reviewed; Journal article, 2023)
      Lytic polysaccharide monooxygenases (LPMOs) catalyze oxidative cleavage of crystalline polysaccharides such as cellulose and are crucial for the conversion of plant biomass in Nature and in industrial applications. Sunlight ...