Blar i Institutt for bioteknologi og matvitenskap på dokumenttype "Journal article"
Viser treff 21-40 av 571
-
Activation of chloramphenicol biosynthesis in Streptomyces venezuelae ATCC 10712 by ethanol shock: Insights from the promoter fusion studies
(Peer reviewed; Journal article, 2016)Background Streptomyces venezuelae ATCC 10712 produces antibiotics chloramphenicol (Cml) and jadomycin (Jad) in response to nutrient limitation and ethanol shock (ES), respectively. Biosynthesis of Cml and Jad was shown ... -
Activation of multiple stress responses in Staphylococcus aureus substantially lowers the minimal inhibitory concentration when combining two novel antibiotic drug candidates
(Peer reviewed; Journal article, 2023)The past few decades have been plagued by an increasing number of infections caused by antibiotic resistant bacteria. To mitigate the rise in untreatable infections, we need new antibiotics with novel targets and drug ... -
Adaptation of central metabolite pools to variations in growth rate and cultivation conditions in Saccharomyces cerevisiae
(Peer reviewed; Journal article, 2021)Background Saccharomyces cerevisiae is a well-known popular model system for basic biological studies and serves as a host organism for the heterologous production of commercially interesting small molecules and proteins. ... -
Addressing uncertainty in genome-scale metabolic model reconstruction and analysis
(Peer reviewed; Journal article, 2021)The reconstruction and analysis of genome-scale metabolic models constitutes a powerful systems biology approach, with applications ranging from basic understanding of genotype-phenotype mapping to solving biomedical and ... -
An adjustable algal chloroplast plug-and-play model for genome-scale metabolic models
(Peer reviewed; Journal article, 2020)The chloroplast is a central part of plant cells, as this is the organelle where the photosynthesis, fixation of inorganic carbon, and other key functions related to fatty acid synthesis and amino acid synthesis occur. ... -
Aerobic and anoxic biodegradability of amines applied in CO2-capture
(Journal article; Peer reviewed, 2017)Integrated and sustainable waste handling is becoming essential in large scale employment of amine-based post combustion CO2 capture and storage (CCS). We have previously proven the feasibility of biological nitrogen removal ... -
Algal Carotenoids: Chemistry, Sources, and Application
(Peer reviewed; Journal article, 2023)Recently, the isolation and identification of various biologically active secondary metabolites from algae have been of scientific interest, with particular attention paid to carotenoids, widely distributed in various ... -
Alginate and tunicate nanocellulose composite microbeads – Preparation, characterization and cell encapsulation
(Peer reviewed; Journal article, 2022)Alginate has been used for decades for cell encapsulation. Cellulose nanofibrils (CNF) from tunicates are desirable in biomedicine due to high molecular weight, purity, crystallinity, and sustainable production. We prepared ... -
Alginate Biosynthesis Factories in Pseudomonas fluorescens : Localization and Correlation with Alginate Production Level
(Journal article; Peer reviewed, 2016)Pseudomonas fluorescens is able to produce the medically and industrially important exopolysaccharide alginate. The proteins involved in alginate biosynthesis and secretion form a multiprotein complex spanning the inner ... -
Alginate Blocks and Block Polysaccharides: A Review
(Peer reviewed; Journal article, 2023)Alginates consist of distinct blocks with different physical properties. This short review focuses on research carried out in Trondheim related to the early discovery of the block structure, their isolation, their different ... -
Alginate gels crosslinked with chitosan oligomers - a systematic investigation into alginate block structure and chitosan oligomer interaction
(Peer reviewed; Journal article, 2021)Three alginates with fundamentally different block structures, poly-M, poly-G, and poly-MG, have been investigated upon ionic crosslinking with chitosan oligosaccharides (CHOS), using circular dichroism (CD), rheology, and ... -
Alginate gels with a combination of calcium and chitosan oligomer mixtures as crosslinkers
(Journal article, 2017)Alginates are polysaccharides that are widely used in relation to their ability to form gels. Recently we reported that alginates may also form gels with chitosan oligomers as crosslinkers (Khong, Aarstad, Skjåk-Bræk, ... -
Alginate hydrogels functionalized with β-cyclodextrin as a local paclitaxel delivery system
(Journal article, 2021)Modification of drug delivery materials with beta-cyclodextrins (β-CyD) is known to increase solubility of poorly water-soluble drugs, protect drugs from degradation and sustain release. In this study, we developed a ... -
Alginate microbeads are complement compatible, in contrast to polycation containing microcapsules, as revealed in a human whole blood model
(Journal article; Peer reviewed, 2011)Alginate microbeads and microcapsules are presently under evaluation for future cell-based therapy. Defining their inflammatory properties with regard to humans is therefore essential. A lepirudine-based human whole blood ... -
Alginate Microencapsulation of Human Islets Does Not Increase Susceptibility to Acute Hypoxia
(Journal article; Peer reviewed, 2013)Islet transplantation in diabetes is hampered by the need of life-long immunosuppression. Encapsulation provides partial immunoprotection but could possibly limit oxygen supply, a factor that may enhance hypoxia-induced ... -
Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation
(Journal article; Peer reviewed, 2016)The inflammatory potential of 12 types of alginate-based microspheres was assessed in a human whole blood model. The inflammatory potential could be categorized from low to high based on the four main alginate microsphere ... -
Alginate Microsphere Encapsulation of Drug-Loaded Nanoparticles: A Novel Strategy for Intraperitoneal Drug Delivery
(Peer reviewed; Journal article, 2022)Alginate hydrogels have been broadly investigated for use in medical applications due to their biocompatibility and the possibility to encapsulate cells, proteins, and drugs. In the treatment of peritoneal metastasis, rapid ... -
Alginate-modifying enzymes: Biological roles and biotechnological uses
(Journal article; Peer reviewed, 2015)Alginate denotes a group of industrially important 1-4-linked biopolymers composed of the C-5-epimers β-D-mannuronic acid (M) and α-L-guluronic acid (G). The polysaccharide is manufactured from brown algae where it constitutes ... -
Alginates as Green Flocculants for Metal Oxide Nanoparticles
(Peer reviewed; Journal article, 2023)Flocculation is used for the removal or separation of colloids, e.g. in water treatment and mineral processing. Alginates are linear, anionic biopolymers composed of mannuronic (M) and guluronic (G) acids. The relative ... -
Alteration of hepato-lipidomic homeostasis in A/J mice fed an environmentally relevant PFAS mixture
(Peer reviewed; Journal article, 2023)In the present study, we have investigated liver lipid homeostasis and corresponding changes in transcript and functional product levels in A/J mice exposed to environmental relevant concentration of per- and polyfluoroalkyl ...