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Population distribution and ancestry of the cancer protective MDM2 SNP285 (rs117039649)
(Journal article; Peer reviewed, 2014)
The MDM2 promoter SNP285C is located on the SNP309G allele. While SNP309G enhances Sp1 transcription factor binding and MDM2 transcription, SNP285C antagonizes Sp1 binding and reduces the risk of breast-, ovary- and ...