Browsing NTNU Open by Author "Zhao, Chun-Mei"
Now showing items 1-14 of 14
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Computational Drug Repositioning and Experimental Validation of Ivermectin in Treatment of Gastric Cancer
Rabben, Hanne-Line; Andersen, Gøran Troseth; Ianevski, Aleksandr; Olsen, Magnus Kringstad; Kainov, Denis; Grønbech, Jon Erik; Wang, Timothy Cragin; Chen, Duan; Zhao, Chun-Mei (Peer reviewed; Journal article, 2021)Objective: The aim of the present study was repositioning of ivermectin in treatment of gastric cancer (GC) by computational prediction based on gene expression profiles of human and mouse model of GC and validations with ... -
Effects of duodenal switch alone or in combination with sleeve gastrectomy on body weight and lipid metabolism in rats
Gudbrandsen, Oddrun Anita; Kodama, Yosuke; Mjøs, Svein Are; Zhao, Chun-Mei; Johannesen, Helene; Brattbakk, Hans-Richard; Haugen, Christine; Kulseng, Bård Eirik; Mellgren, Gunnar; Chen, Duan (Journal article; Peer reviewed, 2014)Background: A combined procedure of sleeve gastrectomy and duodenal switch (SG+DS) has been applied to the treatment of super obesity. The aim of the present study was to test whether duodenal switch alone (DS) leads to ... -
Hypergastrinemia Expands Gastric ECL Cells Through CCK2R Progenitor Cells via ERK Activation
Sheng, Weiwei; Ermanno, Malagola,; Henrik, Nienhüser; Zhengyu, Zhang; Woosook, Kim; Leah, Zamechek; Antonia, Sepulveda; Masahiro, Hata; Yoku, Hayakawa; Zhao, Chun-Mei; Chen, Duan; Timothy C., Wang (Peer reviewed; Journal article, 2020)Background & Aims Enterochromaffin-like (ECL) cells in the stomach express gastrin/cholecystokinin 2 receptor CCK2R and are known to expand under hypergastrinemia, but whether this results from expansion of existing ECL ... -
Mechanistic Comparison between Gastric Bypass vs. Duodenal Switch with Sleeve Gastrectomy in Rat Models
Kodama, Yosuke; Johannessen, Helene; Furnes, Marianne Waldum; Zhao, Chun-Mei; Johnsen, Gjermund; Mårvik, Ronald; Kulseng, Bård; Chen, Duan (Journal article; Peer reviewed, 2013)Background: Both gastric bypass (GB) and duodenal switch with sleeve gastrectomy (DS) have been widely used as bariatric surgeries, and DS appears to be superior to GB. The aim of this study was to better understand the ... -
Naturally occurring phenethyl isothiocyanate-induced inhibition of gastric cancer cell growth by disruption of microtubules
Øverby, Anders; Zhao, Chun-Mei; Bones, Atle M.; Chen, Duan (Journal article; Peer reviewed, 2014)Abstract Background and Aim Phenethyl isothiocyanate (PEITC) derives from vegetables commonly consumed by man and has been demonstrated as a promising chemopreventive agent against several types of cancer. However, the ... -
Neural signaling modulates metabolism of gastric cancer
Rabben, Hanne-Line; Andersen, Gøran Troseth; Olsen, Magnus Kringstad; Øverby, Anders; Ianevski, Aleksandr; Kainov, Denis; Wang, Timothy Cragin; Lundgren, Steinar; Grønbech, Jon Erik; Chen, Duan; Zhao, Chun-Mei (Peer reviewed; Journal article, 2021)Tumors comprise cancer cells and the associated stromal and immune/inflammatory cells, i.e., tumor microenvironment (TME). Here, we identify a metabolic signature of human and mouse model of gastric cancer and show that ... -
Potential Biomarkers of Gastric Intestinal Metaplasia for Early Detection of Gastric Cancer: A bioinformatics study
Geithus, Simon (Master thesis, 2022)Gastrisk tarmmetaplasi er ein irreversibel tilstand som innehar ein auka kreftrisiko. Utviklinga av gastrisk tarmmetaplasi går generelt uhindra føre seg grunna mangelen på kliniske symptom. Der er foreløpig ingen behandling ... -
PYY Plays a Key Role in the Resolution of Diabetes Following Bariatric Surgery in Humans
Chen, Duan; Zhao, Chun-Mei (Journal article; Peer reviewed, 2019)Background Bariatric surgery leads to early and long-lasting remission of type 2 diabetes (T2D). However, the mechanisms behind this phenomenon remain unclear. Among several factors, gut hormones are thought to be crucial ... -
PYY plays a key role in the resolution of diabetes following bariatric surgery in humans
Sam D, Stephen; Claudia, Guida; Watson, Michael; Dempster, Niall; Larraufie, Pierre; Marjot, Thomas; Cargill, Tamsin; Rickers, Lisa; Pavlides, Michael; Tomlinson, Jeremy; Cobbold, Jeremy F.L.; Zhao, Chun-Mei; Chen, Duan; Gribble, Fiona M; Reimann, Frank; Gillies, Richard; Sgromo, Bruno; Rorsman, Patrik; Ryan, John D; Ramracheya, Reshma D. (Journal article; Peer reviewed, 2019)Background Bariatric surgery leads to early and long-lasting remission of type 2 diabetes (T2D). However, the mechanisms behind this phenomenon remain unclear. Among several factors, gut hormones are thought to be crucial ... -
PYY-Dependent Restoration of Impaired Insulin and Glucagon Secretion in Type 2 Diabetes following Roux-En-Y Gastric Bypass Surgery
Ramracheya, Reshma D.; McCulloch, Laura J.; Clark, Anne; Wiggins, David; Johannessen, Helene; Olsen, Magnus Kringstad; Cai, Xing; Zhao, Chun-Mei; Chen, Duan; Rorsman, Patrik (Journal article; Peer reviewed, 2016)Roux-en-Y gastric bypass (RYGB) is a weight-reduction procedure resulting in rapid resolution of type 2 diabetes (T2D). The role of pancreatic islet function in this restoration of normoglycemia has not been fully elucidated. ... -
Tissue responses to hexyl 5-aminolevulinate-induced photodynamic treatment in syngeneic orthotopic rat bladder cancer model: possible pathways of action
Arum, Carl-Jørgen; Gederaas, Odrun Arna; Larsen, Eivind La Puebla; Randeberg, Lise Lyngsnes; Hjelde, Astrid; Krokan, Hans Einar; Svaasand, Lars O.; Chen, Duan; Zhao, Chun-Mei (Journal article; Peer reviewed, 2011)Orthotopic bladder cancer model in rats mimics human bladder cancer with respect to urothelial tumorigenesis and progression. Utilizing this model at pT1 (superficial stage), we analyze the tissue responses to hexyl ... -
Translational Research on Gastric Cancer – Pharmacological Validations of Metabolism-Based Treatments
Rabben, Hanne-Line (Doctoral theses at NTNU;2022:66, Doctoral thesis, 2022)Bakgrunn/mål: Metabolsk reprogrammering er et kjennetegn for kreft og et lovende område for nyutvikling av kreftbehandling. Magekreft er den femte mest vanlige kreftformen på verdensbasis, og er den tredje dødeligste blant ... -
Translational Studies of Eating Behavior and Obesity Treatment
Olsen, Magnus Kringstad (Doctoral theses at NTNU;2017:280, Doctoral thesis, 2017) -
Vagotomy and Gastric Tumorigenesis
Rabben, Hanne-Line; Zhao, Chun-Mei; Hayakawa, Yoku; Wang, Timothy C.; Chen, Duan (Journal article, 2016)Vagotomy reduces gastric acid secretion and was therefore introduced as a surgical treatment for peptic ulcers in the 1970s. Later, it was replaced by acid reducing medication, such as histamine type 2 (H2) receptor ...