Browsing NTNU Open by Author "Ye, Jing"
Now showing items 1-16 of 16
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Analysis of Spatial Memory Cell Types Projections in Entorhino-Entorhinal Circuitry Using Electronphysiological Neural Recordings Combined with Optogenetics Application
Marzban, Nader (Master thesis, 2015)Recent studies have revealed that all functional cell types in superficial layers of medial entorhinal cortex have projections to the hippocampus. Furthermore, hippocampal functions in connection with neural circuits in ... -
Assessing the Electrophysiological Functionality of Place Cells in TDG-depleted Hippocampus
Opsahl, Karoline (Master thesis, 2023)Når dyr utforsker nye omgivelser, dannes det romlige minner som oppdateres med erfaring og hentes frem igjen ved gjeneksponering for det samme miljøet. Koordinert modifikasjon av synaptisk styrke mellom de parahippocampa ... -
Assessing the Role of TDG in the Hippocampus-dependent Memory using Transgenic Mouse Models and rAAV Viral Tools
Døskeland, Dagny Sanden (Master thesis, 2022)Tymin DNA-glykosylase (TDG) er et enzym med viktige roller i genomisk reperasjon og epigenetisk regulering. Tiltredende bevis indikerer en viktig rolle for TDG i aktiv DNA-demetylering. DNA-methylering har en regulerende ... -
Characterizing the newly generated CamKIIα-Tdg-/- mouse model
Nielsen, Liv Støldal (Master thesis, 2023)Tymin DNA glycosilase (TDG) er et enzym som har en viktig rolle i genom reparasjon via fjerningen av T/G uoverensstemmelser. Nyere forskning viser at TDG også har en aktiv rolle i DNA demetylering, noe som tilsier at den ... -
DNA repair enzyme NEIL3 enables a stable neural representation of space by shaping transcription in hippocampal neurons
Kunath, Nicolas; Bugaj, Anna Maria; Bigonah, Pegah; Fernandez Berrocal, Marion Silvana; Bjørås, Magnar; Ye, Jing (Peer reviewed; Journal article, 2021)DNA repair enzymes are essential for the maintenance of the neuronal genome and thereby proper brain functions. Emerging evidence links DNA repair to epigenetic gene regulation; however, its contribution to different ... -
DNA Repair Enzyme NEIL3 Impacts Hippocampal Spatial Representations
Saasen, Vidar Langseth (Master thesis, 2022)Endonuclease VIII-like 3 (NEIL3) DNA glycosylase er et enzym som spiller en rolle i initieringen av en viktig DNA reparasjonsprosess. I den siste tiden har det kommet frem nye funn som fremhever rollene NEIL3 spiller utenom ... -
Entorhinal fast-spiking speed cells project to the hippocampus
Ye, Jing; Witter, Menno; Moser, May-Britt; Moser, Edvard Ingjald (Journal article; Peer reviewed, 2018)The mammalian positioning system contains a variety of functionally specialized cells in the medial entorhinal cortex (MEC) and the hippocampus. In order for cells in these systems to dynamically update representations in ... -
Establishing a Radial Arm Maze Task to Investigate the Role of TDG in Hippocampus-Dependent Memory
Wilson, Angus Olav (Master thesis, 2024)Identifiseringen av hippocampus (HPC) som sentrum for både eksplisitt hukommelse og romlig navigasjon har tilrettelagt for målrettede eksperimenter for å forstå mekanismene bak dannelsen av hukommelse. En bredt akseptert ... -
Functional Dissection of Local Medial Entorhinal Cortex Subcircuit
Wågen, Rine Sørlie (Master thesis, 2013)The superficial layers of the medial entorhinal cortex(MEC) contain serval functionally specialized spatial cell types. suck a grid cells, head direction cells, border cells and cells with conjunctive properties. It is ... -
Impact of NEIL3 on neuronal maturation and organization in the hippocampal formation (HF) and medial entorhinal cortex (MEC)
Vankova, Ana (Master thesis, 2019)DNA damage is proposed to be the reason for mutations to occur. Base excision repair (BER) is the main pathway utilized by the brain to repair oxidative DNA damage. Defects in BER have been linked to the development of ... -
The impact of the DNA glycosylase NEIL3 on neural coding of spatial learning and memory
Kunath, Nicolas (Doctoral theses at NTNU;2021:1, Doctoral thesis, 2021) -
A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment
Lin, Xiaolin; Wang, Wei; Yang, Mingyi; Damseh, Nadirah; Sousa, Mirta; Jacob, Fadi; lång, anna ulrika; Kristiansen, Elise; Pannone, Marco; Kissova, Miroslava; Almaas, Runar; Kusnierczyk, Anna; Siller, Richard; Shahrour, Maher; Al-Ashhab, Motee; Abu-Libdeh, Bassam; Tang, Wannan; Slupphaug, Geir; Elpeleg, Orly; Bøe, Stig Ove; Eide, Lars; Sullivan, Gareth John; Rinholm, Johanne Egge; Song, Hongjun; Ming, Guo-li; van Loon, Barbara; Edvardson, Simon; Ye, Jing; Bjørås, Magnar (Peer reviewed; Journal article, 2023)Background Oxidation Resistance 1 (OXR1) gene is a highly conserved gene of the TLDc domain-containing family. OXR1 is involved in fundamental biological and cellular processes, including DNA damage response, antioxidant ... -
NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice
Hildrestrand, Gunn Annette; Rolseth, Veslemøy; Kunath, Nicolas; Suganthan, Rajikala; Jensen, Vidar; Bugaj, Anna Maria; Fernandez Berrocal, Marion Silvana; SIkko, Sunniva Bøe; Vetlesen, Susanne; Kusnierczyk, Anna; Olsen, Ann-Karin Hardie; Gutzkow, Kristine Bjerve; Rowe, Alexander D.; Wang, Wei; Moldestad, Olve; Syrstad, Monika; Slupphaug, Geir; Eide, Lars; Klungland, Arne; Sætrom, Pål; Luna, Luisa; Ye, Jing; Scheffler, Katja; Bjørås, Magnar (Peer reviewed; Journal article, 2021)Oxidative DNA damage in the brain has been implicated in neurodegeneration and cognitive decline. DNA glycosylases initiate base excision repair (BER), the main pathway for oxidative DNA base lesion repair. NEIL1 and NEIL3 ... -
Parp3 promotes astrocytic differentiation through a tight regulation of Nox4-induced ROS and mTorc2 activation
Rodriguez-Vargas, José-Manuel; Martin-Hernandez, Kathline; Wang, Wei; Kunath, Nicolas; Suganthan, Rajikala; Amé, Jean-Christophe; Francisco, Javier Oliver Pozo; Ye, Jing; Bjørås, Magnar; Dantzer, Françoise (Peer reviewed; Journal article, 2020)Parp3 is a member of the Poly(ADP-ribose) polymerase (Parp) family that has been characterized for its functions in strand break repair, chromosomal rearrangements, mitotic segregation and tumor aggressiveness. Yet its ... -
The functional role of NEIL3 DNA glycosylase in the hippocampus
Heggedal, Mina (Master thesis, 2022)Tiltagende bevis tyder på at NEIL3 har viktige funksjoner i hjernen. Studier med gnagere har avslørt et diskret ekspresjonsmønster av NEIL3 i den subgranulære sonen av dentate gyrus og i den subventrikulære sonen av de ... -
The role of TDG-mediated DNA demethylation in the entorhinal-hippocampal spatial representation system
Innvær, Konstanse Skogøy (Master thesis, 2022)Hukommelsestap og kognitive svekkelser er ofte sett med aldring. Degenerasjonen sees ofte i sammenheng med epigenetisk endring, som i DNA metylering og demetylering. Flere studier som omhandler 5-hydroxymethylcytosine ...