• "Assaying sensory ciliopathies using calcium biosensor expression in zebrafish ciliated olfactory neurons" 

      Bergboer, JGM; Wyatt, Cameron; Austin-Tse, C; Yaksi, Emre; Drummond, IA (Journal article; Peer reviewed, 2018)
      Background Primary cilia mediate signal transduction by acting as an organizing scaffold for receptors, signalling proteins and ion channels. Ciliated olfactory sensory neurons (OSNs) organize olfactory receptors and ion ...
    • Connectivity and Sequences in the Zebrafish brain 

      Øverli, Marian Helcl (Master thesis, 2020)
      Nevral aktivitet i hjernen til zebrafisken er et biologisk system som er svært vanskelig å måle med høy grad av evnen for å reprodusere resultater. Dette er fordi stimuleringen av de ulike delene i hjernen kan variere i ...
    • Connectome inference and cluster extraction from calcium imaging 

      Aronsen, Tord (Master thesis, 2017)
      This is a study of calcium imaging recordings from the spontaneous activity in the habenula and telencephalon region in juvenile and dormant zebrafish. The zebrafish is a model organism that, with some genetic manipulation, ...
    • Defensive Behaviors - Manipulations of the Habenula-Raphe System in Freely Behaving Juvenile Zebrafish 

      Håheim, Oda Bjørnevik (Master thesis, 2020)
      I møte med fare er frykt nødvendig for å initiere «fight-or-flight»-repsonsen, og angst fungerer som en mekanisme for risikovurdering for å estimere nivået av trussel og riktig atferds-respons. Til sammen utgjør disse to ...
    • Developing real-time tracking software and setup for studying active avoidance conditioning in zebrafish 

      Palumbo, Fabrizio (Master thesis, 2016)
      The cognitive capabilities of fish have historically been underestimated and, in many respects, they are comparable to birds and mammals. Currently, an increasing number of behavioural neuroscience laboratories have started ...
    • Developmental mechanisms of spontaneous and sensory evoked activity in the zebrafish habenula 

      Fore, Stephanie (Doctoral theses at NTNU;2020:306, Doctoral thesis, 2020)
      Utviklingsmekanismer for spontan- og sensorisk vekket aktivitet i habenula i sebrafisk For å kunne utføre fleksible endringer i vår atferd må vi kunne samle inn og evaluere informasjon som kommer fra både interne kilder ...
    • Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain 

      Dgama, Percival Paul Menino; Qiu, Tao; Cosacak, Mehmet Ilyas; Rayamajhi, Dheeraj; Konac, Ahsen; Hansen, Jan Niklas; Ringers, Christa; Acuna Hinrichsen, Francisca Daniela; Hui, Subhra; Olstad, Emilie Willoch; Chong, Yan Ling; Lim, Charlton Kang An; Gupta, Astha; Ng, Chee Peng; Nilges, Benedikt S.; Kashikar, Nachiket; Wachten, Dagmar; Liebl, David; Kikuchi, Kazu; Kizil, Caghan; Yaksi, Emre; Roy, Sudipto; Jurisch-Yaksi, Nathalie (Peer reviewed; Journal article, 2021)
      Motile cilia defects impair cerebrospinal fluid (CSF) flow and can cause brain and spine disorders. The development of ciliated cells, their impact on CSF flow, and their function in brain and axial morphogenesis are not ...
    • Evolutionary conserved brainstem circuits encode category, concentration and mixtures of taste 

      Vendrell-Llopis, Nuria; Yaksi, Emre (Journal article; Peer reviewed, 2015)
      Evolutionary conserved brainstem circuits are the first relay for gustatory information in the vertebrate brain. While the brainstem circuits act as our life support system and they mediate vital taste related behaviors, ...
    • Experience-dependent plasticity modulates ongoing activity in the antennal lobe and enhances odor representations 

      Franco, Luis M.; Yaksi, Emre (Peer reviewed; Journal article, 2021)
      Ongoing neural activity has been observed across several brain regions and is thought to reflect the internal state of the brain. Yet, it is important to understand how ongoing neural activity interacts with sensory ...
    • Functional properties of habenular neurons are determined by developmental stage and sequential neurogenesis 

      Fore, Stephanie Liesbeth; Acuna Hinrichsen, Francisca Daniela; Mutlu, Aytac Kadir; Bartoszek-Kandler, Ewelina Magdalena; Serneels, Bram; Faturos, Nicholas Guy; Chau, Khac Thanh Phong; Cosacak, Mehmet Ilyas; Diaz Verdugo, Carmen; Palumbo, Fabrizio; Ringers, Christa; Jurisch-Yaksi, Nathalie; Kizil, Caghan; Yaksi, Emre (Peer reviewed; Journal article, 2020)
      The developing brain undergoes drastic alterations. Here, we investigated developmental changes in the habenula, a brain region that mediates behavioral flexibility during learning, social interactions, and aversive ...
    • Functional properties of habenular neurons are determined by developmental stage and sequential neurogenesis 

      Fore, Stephanie Liesbeth; Acuna Hinrichsen, Francisca Daniela; Mutlu, Aytac Kadir; Bartoszek-Kandler, Ewelina Magdalena; Chau, Khac Thanh Phong; Diaz Verdugo, Carmen; Palumbo, Fabrizio; Ringers, Christa; Jurisch-Yaksi, Nathalie; Yaksi, Emre; Serneels, Bram (Peer reviewed; Journal article, 2020)
      The developing brain undergoes drastic alterations. Here, we investigated developmental changes in the habenula, a brain region that mediates behavioral flexibility during learning, social interactions, and aversive ...
    • Functional properties of habenular neurons are determined by developmental stage and sequential neurogenesis. 

      Forè, Stèphanie; Hinrichsen, Francisca; Mutlu, Kadir; Bartoszek, Ewelina; Yaksi, Emre (Peer reviewed; Journal article, 2020)
      The developing brain undergoes drastic alterations. Here, we investigated developmental changes in the habenula, a brain region that mediates behavioral flexibility during learning, social interactions, and aversive ...
    • Glia-neuron interactions underlie state transitions to generalized seizures 

      Diaz Verdugo, Carmen; Myren-Svelstad, Sverre; Aydin, Ecem; Van Hoeymissen, Evelien; Deneubourg, Celine; Vanderhaeghe, Silke; Vancraeynest, Julie; Pelgrims, Robbrecht; Casacak, Mehmet Ilyas; Muto, Akira; Kawakami, Koichi; Jurisch-Yaksi, Nathalie; Yaksi, Emre (Journal article; Peer reviewed, 2019)
      Brain activity and connectivity alter drastically during epileptic seizures. The brain networks shift from a balanced resting state to a hyperactive and hypersynchronous state. It is, however, less clear which mechanisms ...
    • Gustatory-mediated avoidance of bacterial lipopolysaccharides via TRPA1 activation in Drosophila 

      Soldano, Alessia; Alpizar, Yeranddy A; Boonen, Brett; Franco, Luis; Lopez-Requena, Alejandro; Liu, Guangda; Mora, Natalia; Yaksi, Emre; Voets, Thomas; Vennekens, Rudi; Hassan, Bassem A; Talavera, Karel (Journal article; Peer reviewed, 2016)
      Detecting pathogens and mounting immune responses upon infection is crucial for animal health. However, these responses come at a high metabolic price (McKean and Lazzaro, 2011, Kominsky et al., 2010), and avoiding pathogens ...
    • Identification of a neuronal population in the telencephalon essential for fear conditioning in zebrafish 

      Lal, Pradeep; Tanabe, Hideyuki; Suster, Maximiliano L; Ailani, Deepak; Kotani, Yuri; Muto, Akira; Itoh, Mari; Iwasaki, Miki; Wada, Hironori; Yaksi, Emre; Kawakami, Koichi (Journal article; Peer reviewed, 2018)
      Background Fear conditioning is a form of learning essential for animal survival and used as a behavioral paradigm to study the mechanisms of learning and memory. In mammals, the amygdala plays a crucial role in fear ...
    • Interhemispheric connections between olfactory bulbs improve odor detection 

      Kermen, Florence; Lal, Pradeep; Faturos, Nicholas G.; Yaksi, Emre (Peer reviewed; Journal article, 2020)
      Interhemispheric connections enable interaction and integration of sensory information in bilaterian nervous systems and are thought to optimize sensory computations. However, the cellular and spatial organization of ...
    • Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity 

      Hotz, Adriana L.; Jamali, Ahmed; Rieser, Nicolas N.; Niklaus, Stephanie; Aydin, Ecem; Myren-Svelstad, Sverre; Lalla, Laetitia Noelle Patricia; Jurisch-Yaksi, Nathalie; Yaksi, Emre; Neuhauss, Stephan C.F. (Peer reviewed; Journal article, 2021)
      Astroglial excitatory amino acid transporter 2 (EAAT2, GLT-1, and SLC1A2) regulates the duration and extent of neuronal excitation by removing glutamate from the synaptic cleft. Hence, an impairment in EAAT2 function could ...
    • Methods for studying the zebrafish brain: Past, present and future 

      Wyatt, Cameron; Bartoszek, Ewelina; Yaksi, Emre (Journal article; Peer reviewed, 2015)
      The zebrafish (Danio rerio) is one of the most promising new model organisms. The increasing popularity of this amazing small vertebrate is evident from the exponentially growing numbers of research articles, funded projects ...
    • Motile cilia and their coordination in the nervous system 

      Ringers, Christa (Doctoral theses at NTNU;2021:296, Doctoral thesis, 2021)
    • Motile-Cilia-Mediated Flow Improves Sensitivity and Temporal Resolution of Olfactory Computations 

      Reiten, Ingrid; Uslu, Fazil Emre; Forè, Stèphanie; Pelgrims, Robbrecht; Ringers, Christa; Diaz Verdugo, Carmen; Hoffmann, Maximilian; Lal, Pradeep; Kawakami, Koichi; Pekkan, Kerem; Yaksi, Emre; Jurisch-Yaksi, Nathalie (Journal article; Peer reviewed, 2017)
      Motile cilia are actively beating hair-like structures that cover the surface of multiple epithelia. The flow that ciliary beating generates is utilized for diverse functions and depends on the spatial location and biophysical ...