Browsing NTNU Open by Author "Widerøe, Marius"
Now showing items 1-13 of 13
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Brain Development after Neonatal Intermittent Hyperoxia-Hypoxia in the Rat Studied by Longitudinal MRI and Immunohistochemistry
Morken, Tora Sund; Nyman, Axel Karl Gottfrid; Sandvig, Ioanna; Torp, Sverre Helge; Skranes, Jon Sverre; Goa, Pål Erik; Brubakk, Ann-Mari; Widerøe, Marius (Journal article; Peer reviewed, 2013)Background: Neonatal intermittent hyperoxia-hypoxia (IHH) is involved in the pathogenesis of retinopathy of prematurity. Whether similar oxygen fluctuations will create pathological changes in the grey and white matter ... -
Brain development after postnatal growth restriction and intermittent hyperoxia hypoxia in the neonatal rat : a longitudinal MRI study
Olsen, Jennifer Tatar (Master thesis, 2016)Children born prematurely are commonly exposed to perinatal events such as infections, apneutic attacks and poor lung performance. These conditions put the children at risk of a reduced oxygen uptake and tissue hypoxia. ... -
Diffusion-weighted MRI for early detection and characterization of prostate cancer in the transgenic adenocarcinoma of the mouse prostate model
Hill, Deborah Katherine; Kim, Eugene; Teruel, Jose Ramon; Jamin, Yann; Widerøe, Marius; Søgaard, Caroline Danielsen; Størkersen, Øystein; Nava Rodriguez, Daniel; Heindl, Andreas; Yuan, Yinyin; Bathen, Tone Frost; Moestue, Siver Andreas (Journal article; Peer reviewed, 2016)Purpose To improve early diagnosis of prostate cancer to aid clinical decision-making. Diffusion-weighted magnetic resonance imaging (DW-MRI) is sensitive to water diffusion throughout tissues, which correlates with ... -
Early metabolite changes after melatonin treatment in neonatal rats with hypoxic-ischemic brain injury studied by in-vivo 1H MR spectroscopy
Berger, Hester Rijkje; Nyman, Axel Karl Gottfrid; Morken, Tora Sund; Vettukattil, Muhammad Riyas; Brubakk, Ann-Mari; Widerøe, Marius (Journal article; Peer reviewed, 2017)Melatonin is a promising neuroprotective agent after perinatal hypoxic-ischemic (HI) brain injury. We used in-vivo 1H magnetic resonance spectroscopy to investigate effects of melatonin treatment on brain metabolism after ... -
Magnetic Resonance Imaging of Hypoxic-Ischemic Brain Injury Development in the Newborn Rat
Widerøe, Marius (Doktoravhandlinger ved NTNU, 1503-8181; 2012:125, Doctoral thesis, 2012) -
Melatonin treatment after neonatal hypoxic-ischemic brain injury: a multimodal MR study
Berger, Hester Rijkje (Doctoral theses at NTNU;2018:63, Doctoral thesis, 2018) -
Multi-modal characterization of vasculature and nanoparticle accumulation in five tumor xenograft models
Sulheim, Einar; Kim, Jana; van Wamel, Annemieke; Kim, Eugene; Snipstad, Sofie; Vidic, Igor; Grimstad, Ingeborg; Widerøe, Marius; Torp, Sverre Helge; Lundgren, Steinar; Waxman, David J.; Davies, Catharina de Lange (Journal article; Peer reviewed, 2018)Preclinical research has demonstrated that nanoparticles and macromolecules can accumulate in solid tumors due to the enhanced permeability and retention effect. However, drug loaded nanoparticles often fail to show increased ... -
Nanoparticle delivery to the brain - By focused ultrasound and self-assembled nanoparticle-stabilized microbubbles
Åslund, Andreas; Berg, Sigrid; Hak, Sjoerd; Mørch, Ýrr Asbjørg; Torp, Sverre Helge; Sandvig, Axel; Widerøe, Marius; Hansen, Rune; Davies, Ruth Catharina de Lange (Journal article, 2015)The blood–brain barrier (BBB) constitutes a significant obstacle for the delivery of drugs into the central nervous system (CNS). Nanoparticles have been able to partly overcome this obstacle and can thus improve drug ... -
Neural and vascular development in a rat model for diseases of prematurity : the influence of intermittent hyperoxia-hypoxia and growth retardation on brain microstructure and retinal vasculature
Adrian, Julia Anna (Master thesis, 2016)Preterm born infants are at high risk of periventricular leukomalacia, a distinct form of white matter damage, and retinopathy of prematurity, a disease affecting the retinal vasculature. Further, they often suffer from ... -
Neuron-astrocyte interactions, pyruvate carboxylation and the pentose phosphate pathway in the neonatal rat brain
Morken, Tora Sund; Brekke, Eva Mari Førland; Håberg, Asta; Widerøe, Marius; Brubakk, Ann-Mari; Sonnewald, Ursula (Journal article; Peer reviewed, 2014)Glucose and acetate metabolism and the synthesis of amino acid neurotransmitters, anaplerosis, glutamate-glutamine cycling and the pentose phosphate pathway (PPP) have been extensively investigated in the adult, but not ... -
Preconditioning Triggered by Carbon Monoxide (CO) Provides Neuronal Protection Following Perinatal Hypoxia-Ischemia
Queiroga, CSF; Tomasi, Simone; Widerøe, Marius; Alves, Paula M.; Vercelli, A.; Vieira, Helena LA (Journal article; Peer reviewed, 2012)Perinatal hypoxia-ischemia is a major cause of acute mortality in newborns and cognitive and motor impairments in children. Cerebral hypoxia-ischemia leads to excitotoxicity and necrotic and apoptotic cell death, in which ... -
Transient effect of melatonin treatment after neonatal hypoxic-ischemic brain injury in rats
Berger, Hester Rijkje; Nyman, Axel Karl Gottfrid; Morken, Tora Sund; Widerøe, Marius (Journal article; Peer reviewed, 2019)Melatonin has potential neuroprotective capabilities after neonatal hypoxia-ischemia (HI), but long-term effects have not been investigated. We hypothesized that melatonin treatment directly after HI could protect against ... -
Unraveling the multifaceted in vivo fate of cancer nanomedicine
Sofias, Alexandros Marios (Doctoral theses at NTNU;2019:369, Doctoral thesis, 2019)