Blar i NTNU Open på forfatter "Widerøe, Marius"

Brain Development after Neonatal Intermittent Hyperoxia-Hypoxia in the Rat Studied by Longitudinal MRI and Immunohistochemistry

Morken, Tora Sund; Nyman, Axel Karl Gottfrid; Sandvig, Ioanna; Torp, Sverre Helge; Skranes, Jon Sverre; Goa, Pål Erik; Brubakk, Ann-Mari; Widerøe, Marius (Journal article; Peer reviewed, 2013)

Background: Neonatal intermittent hyperoxia-hypoxia (IHH) is involved in the pathogenesis of retinopathy of prematurity. Whether similar oxygen fluctuations will create pathological changes in the grey and white matter ...

Brain development after postnatal growth restriction and intermittent hyperoxia hypoxia in the neonatal rat : a longitudinal MRI study

Olsen, Jennifer Tatar (Master thesis, 2016)

Children born prematurely are commonly exposed to perinatal events such as infections, apneutic attacks and poor lung performance. These conditions put the children at risk of a reduced oxygen uptake and tissue hypoxia. ...

Diffusion-weighted MRI for early detection and characterization of prostate cancer in the transgenic adenocarcinoma of the mouse prostate model

Hill, Deborah Katherine; Kim, Eugene; Teruel, Jose Ramon; Jamin, Yann; Widerøe, Marius; Søgaard, Caroline Danielsen; Størkersen, Øystein; Nava Rodriguez, Daniel; Heindl, Andreas; Yuan, Yinyin; Bathen, Tone Frost; Moestue, Siver Andreas (Journal article; Peer reviewed, 2016)

Purpose To improve early diagnosis of prostate cancer to aid clinical decision-making. Diffusion-weighted magnetic resonance imaging (DW-MRI) is sensitive to water diffusion throughout tissues, which correlates with ...

Early metabolite changes after melatonin treatment in neonatal rats with hypoxic-ischemic brain injury studied by in-vivo 1H MR spectroscopy

Berger, Hester Rijkje; Nyman, Axel Karl Gottfrid; Morken, Tora Sund; Vettukattil, Muhammad Riyas; Brubakk, Ann-Mari; Widerøe, Marius (Journal article; Peer reviewed, 2017)

Melatonin is a promising neuroprotective agent after perinatal hypoxic-ischemic (HI) brain injury. We used in-vivo 1H magnetic resonance spectroscopy to investigate effects of melatonin treatment on brain metabolism after ...

Hypoxic-ischemic brain injury: Melatonin treatment with lipid-based nanoparticles

Molska, Alicja (Doctoral thesis, 2021)

Lave nivå av oksygen og begrenset blodforsyning rundt fødsel, også kjent som perinatal hypoksisk iskemi (HI), kan forårsake hjerneskade gjennom en progressiv kaskade (1). HIindusert hjerneskade er en av de viktigste årsakene ...

Magnetic Resonance Imaging of Hypoxic-Ischemic Brain Injury Development in the Newborn Rat

Widerøe, Marius (Doktoravhandlinger ved NTNU, 1503-8181; 2012:125, Doctoral thesis, 2012)

Melatonin treatment after neonatal hypoxic-ischemic brain injury: a multimodal MR study

Berger, Hester Rijkje (Doctoral theses at NTNU;2018:63, Doctoral thesis, 2018)

Melatonin treatment for neonatal hypoxic ischemic brain injury: Translational barriers and how to break them

Nyman, Axel Karl Gottfrid (Doctoral theses at NTNU;2021:295, Doctoral thesis, 2021)

Norsk sammendrag Hjerneskade i nyfødte (neonatal encefalopati, NE) er en vanlig lidelse med alvorlige konsekvenser for pasientene, deres familier og samfunnet. Den vanligste identifiserbare årsaken til NE er mangel på ...

Multi-modal characterization of vasculature and nanoparticle accumulation in five tumor xenograft models

Sulheim, Einar; Kim, Jana; van Wamel, Annemieke; Kim, Eugene; Snipstad, Sofie; Vidic, Igor; Grimstad, Ingeborg; Widerøe, Marius; Torp, Sverre Helge; Lundgren, Steinar; Waxman, David J.; Davies, Catharina de Lange (Journal article; Peer reviewed, 2018)

Preclinical research has demonstrated that nanoparticles and macromolecules can accumulate in solid tumors due to the enhanced permeability and retention effect. However, drug loaded nanoparticles often fail to show increased ...

Nanoparticle delivery to the brain - By focused ultrasound and self-assembled nanoparticle-stabilized microbubbles

Åslund, Andreas; Berg, Sigrid; Hak, Sjoerd; Mørch, Ýrr Asbjørg; Torp, Sverre Helge; Sandvig, Axel; Widerøe, Marius; Hansen, Rune; Davies, Ruth Catharina de Lange (Journal article, 2015)

The blood–brain barrier (BBB) constitutes a significant obstacle for the delivery of drugs into the central nervous system (CNS). Nanoparticles have been able to partly overcome this obstacle and can thus improve drug ...

Neural and vascular development in a rat model for diseases of prematurity : the influence of intermittent hyperoxia-hypoxia and growth retardation on brain microstructure and retinal vasculature

Adrian, Julia Anna (Master thesis, 2016)

Preterm born infants are at high risk of periventricular leukomalacia, a distinct form of white matter damage, and retinopathy of prematurity, a disease affecting the retinal vasculature. Further, they often suffer from ...