Browsing NTNU Open by Author "Warrington, Nicole Maree"
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A cautionary note on using Mendelian randomization to examine the Barker hypothesis and Developmental Origins of Health and Disease (DOHaD)
D'Urso, Shannon; Wang, Geng; Hwang, Liang-Dar; Moen, Gunn-Helen; Warrington, Nicole Maree; Evans, David M. (Journal article; Peer reviewed, 2020)Recent studies have used Mendelian randomization (MR) to investigate the observational association between low birth weight (BW) and increased risk of cardiometabolic outcomes, specifically cardiovascular disease, glycemic ... -
Estimating indirect parental genetic effects on offspring phenotypes using virtual parental genotypes derived from sibling and half sibling pairs
Hwang, Liang-Dar; Tubbs, Justin D.; Luong, Justin; Lundberg, Mischa; Moen, Gunn-Helen; Wang, Geng; Warrington, Nicole Maree; Sham, Pak C.; Cuellar-Partida, Gabriel; Evans, David M. (Peer reviewed; Journal article, 2020)Indirect parental genetic effects may be defined as the influence of parental genotypes on offspring phenotypes over and above that which results from the transmission of genes from parents to their children. However, given ... -
Investigating the causal effect of maternal vitamin B12 and folate levels on offspring birthweight
Moen, Gunn-Helen; Beaumont, Robin N.; Grarup, Niels; Sommer, Christine; Shields, Beverley M.; Lawlor, Debbie A.; Freathy, Rachel M.; Evans, David M.; Warrington, Nicole Maree (Peer reviewed; Journal article, 2021)Background Lower maternal serum vitamin B12 (B12) and folate levels have been associated with lower offspring birthweight, in observational studies. The aim of this study was to investigate whether this relationship is ... -
Mendelian randomization study of maternal influences on birthweight and future cardiometabolic risk in the HUNT cohort
Moen, Gunn-Helen; Brumpton, Ben Michael; Willer, Cristen J.; Åsvold, Bjørn Olav; Birkeland, Kåre I.; Wang, Geng; Neale, Michael C.; Freathy, Rachel M.; Smith, George Davey; Lawlor, Debbie A.; Kirkpatrick, Robert M.; Warrington, Nicole Maree; Evans, David M. (Peer reviewed; Journal article, 2020)There is a robust observational relationship between lower birthweight and higher risk of cardiometabolic disease in later life. The Developmental Origins of Health and Disease (DOHaD) hypothesis posits that adverse ...