Browsing NTNU Open by Author "Warrington, Nicole Maree"
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Causal effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation study
Zhao, Jian; Stewart, Isobel D.; Baird, Denis; Mason, Dan; Wright, John; Zheng, Jie; Gaunt, Tom R.; Evans, David M.; Freathy, Rachel M.; Langenberg, Claudia; Warrington, Nicole Maree; Lawlor, Deborah A.; Borges, Maria Carolina (Peer reviewed; Journal article, 2023)Background Amino acids are key to protein synthesis, energy metabolism, cell signaling and gene expression; however, the contribution of specific maternal amino acids to fetal growth is unclear. Methods We explored the ... -
A cautionary note on using Mendelian randomization to examine the Barker hypothesis and Developmental Origins of Health and Disease (DOHaD)
D'Urso, Shannon; Wang, Geng; Hwang, Liang-Dar; Moen, Gunn-Helen; Warrington, Nicole Maree; Evans, David M. (Journal article; Peer reviewed, 2020)Recent studies have used Mendelian randomization (MR) to investigate the observational association between low birth weight (BW) and increased risk of cardiometabolic outcomes, specifically cardiovascular disease, glycemic ... -
Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data
Warrington, Nicole Maree; Hwang, Liang-Dar; Nivard, Michel G.; Evans, David M. (Peer reviewed; Journal article, 2021)Estimation of direct and indirect (i.e. parental and/or sibling) genetic effects on phenotypes is becoming increasingly important. We compare several multivariate methods that utilize summary results statistics from ... -
Estimating indirect parental genetic effects on offspring phenotypes using virtual parental genotypes derived from sibling and half sibling pairs
Hwang, Liang-Dar; Tubbs, Justin D.; Luong, Justin; Lundberg, Mischa; Moen, Gunn-Helen; Wang, Geng; Warrington, Nicole Maree; Sham, Pak C.; Cuellar-Partida, Gabriel; Evans, David M. (Peer reviewed; Journal article, 2020)Indirect parental genetic effects may be defined as the influence of parental genotypes on offspring phenotypes over and above that which results from the transmission of genes from parents to their children. However, given ... -
A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans
Moksnes, Marta Riise; Hansen, Ailin Falkmo; Wolford, Brooke; Thomas, Laurent Francois; Rasheed, Humaira; Simic, Anica; Bhatta, Laxmi; Brantsæter, Anne Lise; Surakka, Ida; Zhou, Wei; Magnus, Per Minor; Njølstad, Pål Rasmus; Andreassen, Ole; Syversen, Tore; Zheng, Jie; Fritsche, Lars; Evans, David M.; Warrington, Nicole Maree; Nøst, Therese Haugdahl; Åsvold, Bjørn Olav; Flaten, Trond Peder; Willer, Cristen J.; Hveem, Kristian; Brumpton, Ben Michael (Journal article; Peer reviewed, 2024)Trace elements are important for human health but may exert toxic or adverse effects. Mechanisms of uptake, distribution, metabolism, and excretion are partly under genetic control but have not yet been extensively mapped. ... -
Investigating the causal effect of maternal vitamin B12 and folate levels on offspring birthweight
Moen, Gunn-Helen; Beaumont, Robin N.; Grarup, Niels; Sommer, Christine; Shields, Beverley M.; Lawlor, Debbie A.; Freathy, Rachel M.; Evans, David M.; Warrington, Nicole Maree (Peer reviewed; Journal article, 2021)Background Lower maternal serum vitamin B12 (B12) and folate levels have been associated with lower offspring birthweight, in observational studies. The aim of this study was to investigate whether this relationship is ... -
Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk
D’Urso, Shannon; Arumugam, Pooja; Weider, Therese; Hwang, Liang-Dar; Bond, Tom A.; Kemp, John P.; Warrington, Nicole Maree; Evans, David M.; O’Mara, Tracy A.; Moen, Gunn-Helen Øiseth (Peer reviewed; Journal article, 2022)Background Observational epidemiological studies suggest a link between several factors related to ovulation and reproductive function and endometrial cancer (EC) risk; however, it is not clear whether these relationships ... -
Mendelian randomization study of maternal coffee consumption and its influence on birthweight, stillbirth, miscarriage, gestational age and pre-term birth
Brito Nunes, Caroline; Huang, Peiyuan; Wang, Geng; Lundberg, Mischa; D'Urso, Shannon; Wootton, Robyn E; Borges, Maria Carolina; Lawlor, Deborah A.; Warrington, Nicole Maree; Evans, David M.; Hwang, Liang-Dar; Moen, Gunn-Helen Øiseth (Peer reviewed; Journal article, 2023)Background Coffee consumption has been associated with several adverse pregnancy outcomes, although data from randomized–controlled trials are lacking. We investigate whether there is a causal relationship between coffee ... -
Mendelian randomization study of maternal influences on birthweight and future cardiometabolic risk in the HUNT cohort
Moen, Gunn-Helen; Brumpton, Ben Michael; Willer, Cristen J.; Åsvold, Bjørn Olav; Birkeland, Kåre I.; Wang, Geng; Neale, Michael C.; Freathy, Rachel M.; Smith, George Davey; Lawlor, Debbie A.; Kirkpatrick, Robert M.; Warrington, Nicole Maree; Evans, David M. (Peer reviewed; Journal article, 2020)There is a robust observational relationship between lower birthweight and higher risk of cardiometabolic disease in later life. The Developmental Origins of Health and Disease (DOHaD) hypothesis posits that adverse ... -
Using Genomic Structural Equation Modeling to Partition the Genetic Covariance Between Birthweight and Cardiometabolic Risk Factors into Maternal and Offspring Components in the Norwegian HUNT Study
Moen, Gunn-Helen Øiseth; Nivard, Michel; Bhatta, Laxmi; Warrington, Nicole Maree; Willer, Cristen; Åsvold, Bjørn Olav; Brumpton, Ben Michael; Evans, David M. (Peer reviewed; Journal article, 2022)The Barker Hypothesis posits that adverse intrauterine environments result in fetal growth restriction and increased risk of cardiometabolic disease through developmental compensations. Here we introduce a new statistical ...