Browsing NTNU Open by Author "Wargelius, Anna"
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CRISPR/Cas9-mediated ablation of elovl2 in Atlantic salmon (Salmo salar L.) inhibits elongation of polyunsaturated fatty acids and induces Srebp-1 and target genes
Winge, Per; Datsomor, Alex; Olsen, Rolf Erik; Jin, Yang; Vik, Jon Olav; Edvardsen, Rolf; Grammes, Fabian; Wargelius, Anna; Li, Keshuai (Journal article; Peer reviewed, 2019)Atlantic salmon can synthesize polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (20:5n-3), arachidonic acid (20:4n-6) and docosahexaenoic acid (22:6n-3) via activities of very long chain fatty acyl elongases ... -
CRISPR/Cas9-mediated editing of Δ5 and Δ6 desaturases impairs Δ8-desaturation and docosahexaenoic acid synthesis in Atlantic salmon (Salmo salar L.)
Datsomor, Alex Kojo; Olsen, Rolf Erik; Madaro, Angelico; Bones, Atle M.; Edvardsen, Rolf Brudvik; Wargelius, Anna; Winge, Per (Journal article; Peer reviewed, 2019)The in vivo functions of Atlantic salmon fatty acyl desaturases (fads2), Δ6fads2-a, Δ6fads2-b, Δ6fads2-c and Δ5fads2 in long chain polyunsaturated fatty acid (LC-PUFA) synthesis in salmon and fish in general remains to be ... -
Functional Annotation of All Salmonid Genomes (FAASG): an international initiative supporting future salmonid research, conservation and aquaculture
Macqueen, Daniel J.; Primmer, Craig R.; Houston, Ross D.; Nowak, Barbara F.; Bernatchez, Louis; Bergseth, Steinar; Davidson, William S.; Gallardo-Escárate, Cristian; Goldammer, Tom; Guiguen, Yann; Iturra, Patricia; Kijas, James W.; Koop, Ben F.; Lien, Sigbjørn; Maass, Alejandro; Martin, Samuel A. M.; McGinnity, Philip; Montecino, Martin; Naish, Kerry; Nichols, Krista M.; Ólafsson, Kristinn; Omholt, Stig William; Palti, Yniv; Plastow, Graham S.; Rexroad, Caird E. 3rd; Rise, Matthew L.; Ritchie, Rachael J.; Sandve, Simen Rød; Schulte, Patricia M.; Tello, Alfredo; Vidal, Rodrigo; Vik, Jon Olav; Wargelius, Anna; Yáñez, José Manuel (Journal article; Peer reviewed, 2017)We describe an emerging initiative - the ‘Functional Annotation of All Salmonid Genomes’ (FAASG), which will leverage the extensive trait diversity that has evolved since a whole genome duplication event in the salmonid ... -
Targeted mutagenesis of Δ5 and Δ6 fatty acyl desaturases induce dysregulation of lipid metabolism in Atlantic salmon (Salmo salar)
Jin, Yang; Datsomor, Alex Kojo; Olsen, Rolf Erik; Vik, Jon Olav; Torgersen, Jacob Seilø; Edvardsen, Rolf Brudvik; Wargelius, Anna; Winge, Per; Grammes, Fabian (Peer reviewed; Journal article, 2020)Background With declining wild fish populations, farmed salmon has gained popularity as a source for healthy long-chain highly unsaturated fatty acids (LC-HUFA). However, the introduction of plant oil in farmed salmon ...