Browsing NTNU Open by Author "Visnes, Torkild"
Now showing items 1-10 of 10
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AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature
Pettersen, Henrik Sahlin; Galashevskaya, Anastasia; Doseth, Berit; Sousa, Mirta; Sarno, Antonio; Visnes, Torkild; Aas, Per Arne; Liabakk, Nina-Beate; Slupphaug, Geir; Sætrom, Pål; Kavli, Bodil Merete; Krokan, Hans Einar (Journal article; Peer reviewed, 2014)tThe most common mutations in cancer are C to T transitions, but their origin has remained elusive.Recently, mutational signatures of APOBEC-family cytosine deaminases were identified in many com-mon cancers, suggesting ... -
A Children’s Health Perspective on Nano- and Microplastics
Sripada, Kam; Wierzbicka, Aneta; Abass, Khaled; Grimalt, Joan O.; Erbe, Andreas; Röllin, Halina B.; Weihe, Pál; Díaz, Gabriela Jiménez; Singh, Randolph Reyes; Visnes, Torkild; Rautio, Arja; Odland, Jon Øyvind; Wagner, Martin (Peer reviewed; Journal article, 2022)Background: Pregnancy, infancy, and childhood are sensitive windows for environmental exposures. Yet the health effects of exposure to nano- and microplastics (NMPs) remain largely uninvestigated or unknown. Although ... -
Development of macrophage characterization assays
Stadheim, Maria (Master thesis, 2020)På tross av lovende fremskritt innen immunterapi, som anses som en ny pilar i kreftbehandling, responderer kun en liten andel pasienter som ønsket på spesifikke behandlinger. Utviklingen av forenklede metoder for studie ... -
DNA excision repair of uracil and 5-fluorouracil in human cancercell lines
Visnes, Torkild (Doktoravhandlinger ved NTNU, 1503-8181; Doktoravhandlinger ved NTNU, 2009:260, Doctoral thesis, 2009)DNA er et tilsynelatende stabilt molekyl, som overføres så å si uten endringer fra unnfangelse til alderdom og fra generasjon til generasjon. Men arvestoffet vårt er ikke så uforanderlig som det kan se ut som. DNA kan ... -
Impact of DNA glycosylases on epigenetic regulation of gene expression via active DNA demethylation in human cells
Naderi, Sheida (Master thesis, 2022)Chemical modification of DNA bases is a key strategy employed by cells in epigenetic regulation of gene expression. 5-methylcytosine (5mC) is an important epigenetic mark and transcription repressor in the human genome ... -
Improved Synthetic Methodology, Substrate Scope and X-ray Crystal Structure for N, N’-disubstituted Guanidines
Elumalai, Vijayaragavan; Eigner, Václav; Visnes, Torkild; Sundby, Eirik; Hoff, Bård Helge (Peer reviewed; Journal article, 2024)Guanidine is a privileged scaffold in drug discovery. Herein we report our investigations into the acid promoted amination of pyrimidine-bearing cyanamide to produce N, N’-disubstituted guanidines. Hydrochloric acid was ... -
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation
Visnes, Torkild; Armando, Cazares-Körner; Wenjing, Hao; Wallner, Olov; Masuyer, Geoffrey; Loseva, Olga; Mortusewicz, Oliver; Wiita, Elisee; Sarno, Antonio; Manoilov, Aleksandr; Astorga-Wells, Juan; Jemth, Ann-Sofie; Pan, Lang; Sanjiv, Kumar; Karsten, Stella; Gokturk, Camilla; Grube, Maurice; Evert J, Homan; Hanna, Bishoy Magdi Fekry; Cynthia, Paulin BJ; pham, Therese; Rasti, Azita; Warpman Berglund, Ulrika; von Nikolai, Catharina; Benitez-Buelga, Carlos; Koolmeister, Tobias; Ivanic, Dag; Iliev, Petar; Scobie, Martin; Krokan, Hans Einar; Baranczewski, Pawel; Artursson, Per; Altun, Mikael; Jenmalm-Jensen, Annika; Kalderen, Christina; Xueqing, Ba; Zubarev, Roman A.; Stenmark, Pål; Boldogh, Istvan; Helleday, Thomas (Journal article; Peer reviewed, 2018)The onset of inflammation is associated with reactive oxygen species and oxidative damage to macromolecules like 7,8-dihydro-8-oxoguanine (8-oxoG) in DNA. Because 8-oxoguanine DNA glycosylase 1 (OGG1) binds 8-oxoG and ... -
Systematic review: predictive value of organoids in colorectal cancer
Sakshaug, Baard Cristoffer; Folkesson, Emma Evelina; Haukaas, Tonje Husby; Visnes, Torkild; Flobak, Åsmund (Peer reviewed; Journal article, 2023)While chemotherapy alone or in combination with radiotherapy and surgery are important modalities in the treatment of colorectal cancer, their widespread use is not paired with an abundance of diagnostic tools to match ... -
Targeting OGG1 arrests cancer cell proliferation by inducing replication stress
Visnes, Torkild; Benitez-Buelga, Carlos; Cázares-Körner, Armando; Sanjiv, Kumar; Hanna, Bishoy M F; Mortusewicz, Oliver; Rajagopal, Varshni; Albers, Julian J.; Hagey, Daniel W.; Bekkhus, Tove; Eshtad, Saeed; Baquero, Juan Miguel; Masuyer, Geoffrey; Wallner, Olov; Müller, Sarah; Pham, Therese; Gokturk, Camilla; Rasti, Azita; Suman, Sharda; Torres-Ruiz, Raúl; Sarno, Antonio; Wiita, Elisée; Homan, Evert; Karsten, Stella; Marimuthu, Karthick; Michel, M; Koolmeister, Tobias; Scobie, Martin; Loseva, Olga; Almlöf, Ingrid; Unterlass, Judith Edda; Pettke, Aleksandra; Boström, Johan; Pandey, Monica; Gad, Helge; Herr, Patrick; Jemth, Ann-Sofie; El Andaloussi, Samir; Kalderén, Christina; Rodriguez-Perales, Sandra; Benítez, Javier; Krokan, Hans Einar; Altun, Mikael; Stenmark, Pål; Berglund, Ulrika Warpman; Helleday, Thomas (Peer reviewed; Journal article, 2020)Abstract Altered oncogene expression in cancer cells causes loss of redox homeostasis resulting in oxidative DNA damage, e.g. 8-oxoguanine (8-oxoG), repaired by base excision repair (BER). PARP1 coordinates BER and relies ... -
UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation
Pettersen, Henrik Sahlin; Visnes, Torkild; Vågbø, Cathrine Broberg; Svaasand, Eva K; Doseth, Berit; Slupphaug, Geir; Kavli, Bodil Merete; Krokan, Hans Einar (Journal article; Peer reviewed, 2011)Cytotoxicity of 5-fluorouracil (FU) and 5-fluoro-2′-deoxyuridine (FdUrd) due to DNA fragmentation during DNA repair has been proposed as an alternative to effects from thymidylate synthase (TS) inhibition or RNA incorporation. ...