• A computational pipeline for quantification of mouse myocardial stiffness parameters 

      Nordbø, Øyvind; Lamata, P.; Land, Sander; Niederer, Steven A.; Aronsen, Jan Magnus; Louch, William Edward; Sjaastad, Ivar; Martens, Harald; Gjuvsland, Arne Bjørke; Tøndel, Kristin; Torp, Hans; Lohezic, M; Schneider, Jürgen; Remme, Espen W.; Smith, Nicolas P; Omholt, Stig W; Vik, Jon Olav (Journal article; Peer reviewed, 2014)
      The mouse is an important model for theoretical–experimental cardiac research, and biophysically based whole organ models of the mouse heart are now within reach. However, the passive material properties of mouse myocardium ...
    • A systemic study of lipid metabolism regulation in salmon fingerlings and early juveniles fed plant oil 

      Jin, Yang; Olsen, Rolf Erik; Gillard, Gareth B.; Østensen, Mari-Ann; Korsvoll, Sven A.; Santi, Nina; Vik, Jon Olav; Sandve, Simen Rød; Olsen, Yngvar (Journal article; Peer reviewed, 2018)
      In salmon farming, the scarcity of fish oil has driven a shift towards the use of plant-based oil from vegetable or seed, leading to fish feed low in long-chain PUFA (LC-PUFA) and cholesterol. Atlantic salmon has the ...
    • Centre for Digital Life Norway - Annual report 2017 

      Johansen, Finn-Eirik; Brautaset, Trygve; Aune, Marie Hjelmseth; Patriksson, Alexandra; Falkenberg, Liv Eggset; Kleppe, Rune; Dick, Gunnar; Strand, Berit Løkensgard; Eijsink, Vincent; Røyne, Anja; Goksøyr, Anders; Svendsen, John Sigurd Mjøen; Fyhn, Marianne; Vik, Jon Olav; Wentzel, Alexander; Aksnes, Astrid; Bruheim, Per; Carlsen, Sven Magnus; Åm, Heidrun (Research report, 2018)
    • Comparative transcriptomics reveals domestication‐associated features of Atlantic salmon lipid metabolism 

      Jin, Yang; Olsen, Rolf Erik; Harvey, Thomas Nelson; Østensen, Mari-Ann; Li, Keshuai; Santi, Nina; Vadstein, Olav; Bones, Atle M.; Vik, Jon Olav; Sandve, Simen Rød; Olsen, Yngvar (Peer reviewed; Journal article, 2020)
      Domestication of animals imposes strong targeted selection for desired traits but can also result in unintended selection due to new domestic environments. Atlantic salmon was domesticated in the 1970s and has subsequently ...
    • CRISPR/Cas9-mediated ablation of elovl2 in Atlantic salmon (Salmo salar L.) inhibits elongation of polyunsaturated fatty acids and induces Srebp-1 and target genes 

      Winge, Per; Datsomor, Alex; Olsen, Rolf Erik; Jin, Yang; Vik, Jon Olav; Edvardsen, Rolf; Grammes, Fabian; Wargelius, Anna; Li, Keshuai (Journal article; Peer reviewed, 2019)
      Atlantic salmon can synthesize polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (20:5n-3), arachidonic acid (20:4n-6) and docosahexaenoic acid (22:6n-3) via activities of very long chain fatty acyl elongases ...
    • Effect of regulatory architecture on broad versus narrow sense heritability 

      Wang, Yunpeng; Vik, Jon Olav; Omholt, Stig W; Gjuvsland, Arne Bjørke (Journal article; Peer reviewed, 2013)
      Additive genetic variance (VA) and total genetic variance (VG) are core concepts in biomedical, evolutionary and production-biology genetics. What determines the large variation in reported VA/VG ratios from line-cross ...
    • Functional Annotation of All Salmonid Genomes (FAASG): an international initiative supporting future salmonid research, conservation and aquaculture 

      Macqueen, Daniel J.; Primmer, Craig R.; Houston, Ross D.; Nowak, Barbara F.; Bernatchez, Louis; Bergseth, Steinar; Davidson, William S.; Gallardo-Escárate, Cristian; Goldammer, Tom; Guiguen, Yann; Iturra, Patricia; Kijas, James W.; Koop, Ben F.; Lien, Sigbjørn; Maass, Alejandro; Martin, Samuel A. M.; McGinnity, Philip; Montecino, Martin; Naish, Kerry; Nichols, Krista M.; Ólafsson, Kristinn; Omholt, Stig William; Palti, Yniv; Plastow, Graham S.; Rexroad, Caird E. 3rd; Rise, Matthew L.; Ritchie, Rachael J.; Sandve, Simen Rød; Schulte, Patricia M.; Tello, Alfredo; Vidal, Rodrigo; Vik, Jon Olav; Wargelius, Anna; Yáñez, José Manuel (Journal article; Peer reviewed, 2017)
      We describe an emerging initiative - the ‘Functional Annotation of All Salmonid Genomes’ (FAASG), which will leverage the extensive trait diversity that has evolved since a whole genome duplication event in the salmonid ...
    • Life-stage associated remodeling of lipid metabolism regulation in Atlantic salmon 

      Gillard, Gareth Benjamin; Harvey, Thomas Nelson; Gjuvsland, Arne Bjørke; Jin, Yang; Thomassen, Magny Sissel S.; Lien, Sigbjørn; Leaver, Michael; Torgersen, Jacob Seilø; Hvidsten, Torgeir Rhoden; Vik, Jon Olav; Sandve, Simen Rød (Journal article; Peer reviewed, 2018)
      Atlantic salmon migrates from rivers to sea to feed, grow and develop gonads before returning to spawn in freshwater. The transition to marine habitats is associated with dramatic changes in the environment, including water ...
    • The Atlantic salmon genome provides insights into rediploidization 

      Lien, Sigbjørn; Koop, Ben F; Sandve, Simen Rød; Miller, Jason R.; Kent, Matthew Peter; Nome, Torfinn; Hvidsten, Torgeir Rhoden; Leong, Jong; Minkley, David R.; Zimin, Aleksey; Grammes, Fabian; Grove, Harald; Gjuvsland, Arne Bjørke; Walenz, Brian; Hermansen, Russell A.; von Schalburg, Kristian R.; Rondeau, Eric; Genova, Alex Di; Antony Samy, Jeevan Karloss; Vik, Jon Olav; Vigeland, Magnus Dehli; Caler, Lis; Grimholt, Unni; Jentoft, Sissel; Våge, Dag Inge; de Jong, Pieter J.; Moen, Thomas; Baranski, Matthew; Palti, Yniv; Smith, Douglas W.; Yorke, James A.; Nederbragt, Alexander J.; Tooming-Klunderud, Ave; Jakobsen, Kjetill Sigurd; Jiang, Xuanting; Fan, Dingding; Hu, Yan; Liberles, David A.; Vidal, Rodrigo; Iturra, Patricia; Jones, Steven J.M.; Jonassen, Inge; Maass, Alejandro; Omholt, Stig William; Davidson, William S (Journal article; Peer reviewed, 2016)
      The whole-genome duplication 80 million years ago of the common ancestor of salmonids (salmonid-specific fourth vertebrate whole-genome duplication, Ss4R) provides unique opportunities to learn about the evolutionary fate ...
    • Transcriptional development of phospholipid and lipoprotein metabolism in different intestinal regions of Atlantic salmon (Salmo salar) fry 

      Jin, Yang; Olsen, Rolf Erik; Østensen, Mari-Ann; Gillard, Gareth Benjamin; Korsvoll, Sven Arild; Santi, Nina; Gjuvsland, Arne Bjørke; Vik, Jon Olav; Torgersen, Jacob Seilø; Sandve, Simen Rød; Olsen, Yngvar (Journal article; Peer reviewed, 2018)
      Background It has been suggested that the high phospholipid (PL) requirement in Atlantic salmon (Salmo salar) fry is due to insufficient intestinal de-novo synthesis causing low lipoprotein (LP) production and reduced ...
    • Transcriptional regulation of lipid metabolism when salmon fry switches from endogenous to exogenous feeding 

      Jin, Yang; Olsen, Rolf Erik; Østensen, Mari-Ann; Gillard, Gareth Benjamin; Li, Keshuai; Harvey, Thomas Nelson; Santi, Nina; Vadstein, Olav; Vik, Jon Olav; Sandve, Simen Rød; Olsen, Yngvar (Journal article; Peer reviewed, 2018)
      The onset of first feeding is a critical period for Atlantic salmon (Salmo salar). The fish goes through a dramatic transition, from using the yolk sac as an energy and nutrient resource to rely on exogenous food. However, ...