Browsing NTNU Open by Author "Van der Want, Johannes"
Now showing items 1-7 of 7
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A discrete dopaminergic projection from the incertohypothalamic A13 cell group to the dorsolateral periaqueductal gray in rat
Messanvi, F; Eggens-Meijer, E; Roozendaal, B; Van der Want, Johannes (Journal article; Peer reviewed, 2013)Several findings have indicated an involvement of dopamine in panic and defensive behaviors. The dorsolateral column of the periaqueductal gray (dlPAG) is crucially involved in the expression of panic attacks in humans and ... -
Development of Parvalbumin-Expressing Basket Terminals in Layer II of the Rat Medial Entorhinal Cortex
Berggaard, Nina; Bjerke, Ingvild Elise; Paulsen, Anna Elisabeth Bråthen; Hoang, Linh; Skogaker, Nan Elisabeth Tostrup; Witter, Menno; Van der Want, Johannes (Journal article; Peer reviewed, 2018)Grid cells in layer II of the medial entorhinal cortex (MEC LII) generate multiple regular firing fields in response to the position and speed of an individual within the environment. They exhibit a protracted postnatal ... -
Lipid droplets hypertrophy: A crucial determining factor in insulin regulation by adipocytes
Sanjabi, Bahram; Dashty, Monireh; Ozcan, Behiye; Akbarkhanzadeh, Vishtaseb; Rahimi, Mehran; Vinciguerra, Manlio; Van Rooij, Felix; Al-Lahham, Saad; Sheedfar, Fareeba; Van Kooten, Theo G; Spek, C Arnold; Rowshani, Ajda T; Van der Want, Johannes; Klaassen, Rene; Sijbrands, Eric; Peppelenbosch, MP; Rezaee, Farhad (Journal article; Peer reviewed, 2015)Lipid droplets (LDs) hypertrophy in adipocytes is the main cause of energy metabolic system dysfunction, obesity and its afflictions such as T2D. However, the role of adipocytes in linking energy metabolic disorders with ... -
Localization of NG2 immunoreactive neuroglia cells in the rat locus coeruleus and their plasticity in response to stress
Seifi, M; Corteen, NL; Van der Want, Johannes; Metzger, F; Swinny, JD (Journal article; Peer reviewed, 2014)The locus coeruleus (LC) nucleus modulates adaptive behavioral responses to stress and dysregulation of LC neuronal activity is implicated in stress-induced mental illnesses. The LC is composed primarily of noradrenergic ... -
Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells
Hoffmann, RF; Zarrintan, S; Brandenburg, SM; Kol, A; de Bruin, HG; Jafari, S; Dijk, F; Kalicharan, D; Kelders, M; Gosker, HR; ten Hacken, NHT; Van der Want, Johannes; van Oosterhout, AJM; Heijink, IH (Journal article; Peer reviewed, 2013)Background Cigarette smoking is the major risk factor for COPD, leading to chronic airway inflammation. We hypothesized that cigarette smoke induces structural and functional changes of airway epithelial mitochondria, ... -
Spatiotemporal Distribution of GABAA Receptor Subunits Within Layer II of Mouse Medial Entorhinal Cortex: Implications for Grid Cell Excitability
Berggaard, Nina; Seifi, Mohsen; Van der Want, Johannes; Swinny, Jerome (Journal article; Peer reviewed, 2018)GABAergic parvalbumin-expressing (PV+) interneurons provide powerful inhibitory modulation of grid cells in layer II of the medial entorhinal cortex (MEC LII). However, the molecular machinery through which PV+ cells ... -
Synaptic input as a directional cue for migrating interneuron precursors
Wefers, Annika K; Haberlandt, Christian; Tekin, Nuriye Basdag; Fedorov, D.; Timmermann, A.; Van der Want, Johannes; Chaudhry, Farrukh Abbas; Steinhäuser, Christian; Schilling, K; Jabs, Ronald (Journal article; Peer reviewed, 2017)During CNS development, interneuron precursors have to migrate extensively before they integrate in specific microcircuits. Known regulators of neuronal motility include classical neurotransmitters, yet the mechanisms that ...