Browsing NTNU Open by Author "Valla, Marit"

Now showing items 1-20 of 20

    • Androgen receptor expression in breast cancer subtypes 

      Kraby, Maria Ryssdal (Master thesis, 2016)
      Background The androgen receptor (AR) is frequently expressed in breast cancer, and associated with good prognosis in ER-positive breast cancers. Due to its high prevalence, AR is also a possible target for therapeutic ...

    • The association of women’s birth size with risk of molecular breast cancer subtypes: a cohort study 

      Sandvei, Marie Søfteland; Opdahl, Signe; Valla, Marit; Lagiou, Pagona; Vesterfjell, Ellen Veronika; Rise, Tor Vikan; Overrein, Tina Syvertsen; Skjervold, Anette Hansen; Engstrøm, Monica J; Bofin, Anna M.; Vatten, Lars J. (Peer reviewed; Journal article, 2021)
      Background: Because birth size appears to be positively associated with breast cancer risk, we have studied whether this risk may differ according to molecular breast cancer subtypes. Methods: A cohort of 22,931 women born ...

    • Basal markers and prognosis in luminal breast cancer 

      Engstrøm, Monica J; Valla, Marit; Bofin, Anna M. (Journal article; Peer reviewed, 2017)
      Purpose Basal marker expression in triple-negative breast cancers identifies basal-like tumours, and thus separates the TN group into two prognostic groups. However, the expression and prognostic significance of basal ...

    • CCND1 amplification in breast cancer -associations with proliferation, histopathological grade, molecular subtype and prognosis 

      Valla, Marit; Klæstad, Elise; Ytterhus, Borgny; Bofin, Anna M. (Peer reviewed; Journal article, 2022)
      CCND1 is located on 11q13. Increased CCND1 copy number (CN) in breast cancer (BC) is associated with high histopathological grade, high proliferation, and Luminal B subtype. In this study of CCND1 in primary BCs and ...

    • Characterization of FGD5 expression in primary breast cancers and lymph node metastases 

      Valla, Marit; Mjønes, Patricia; Engstrøm, Monica J; Ytterhus, Borgny; Bordin, Diana Lilian; van Loon, Barbara; Akslen, Lars A.; Vatten, Lars Johan; Opdahl, Signe; Bofin, Anna M. (Journal article; Peer reviewed, 2018)
      Faciogenital dysplasia 5 (FGD5) amplification drives tumor cell proliferation, and is present in 9.5% of breast cancers. We describe FGD5 expression, assess associations between FGD5 amplification and FGD5 expression, and ...

    • DTX3 copy number increase in breast cancer: a study of associations to molecular subtype, proliferation and prognosis 

      Valla, Marit; Opdahl, Signe; Ytterhus, Borgny; Bofin, Anna M. (Journal article; Peer reviewed, 2021)
      Purpose The degree of cell proliferation is important for subclassifcation of breast cancers into prognostic and therapeutic groups. DTX3 has been identifed as a driver of proliferation in luminal breast cancer. In this ...

    • Established and novel methods and biomarkers in breast cancer 

      Skjervold, Anette Hansen (Doctoral theses at NTNU;2024:80, Doctoral thesis, 2024)
      The present thesis is based on three published papers. The work arises from three cohorts of women from Trøndelag county in Norway. These were women born between 1886 and 1977, that were diagnosed with breast cancer (BC). ...

    • FastPathology: An open-source platform for deep learning-based research and decision support in digital pathology 

      Pedersen, André; Valla, Marit; Bofin, Anna Mary; Perez de Frutos, Javier; Reinertsen, Ingerid; Smistad, Erik (Peer reviewed; Journal article, 2021)
      Deep convolutional neural networks (CNNs) are the current state-of-the-art for digital analysis of histopathological images. The large size of whole-slide microscopy images (WSIs) requires advanced memory handling to read, ...

    • FGD5 amplification in breast cancer patients is associated with tumor proliferation and a poorer prognosis 

      Valla, Marit; Engstrøm, Monica J; Ytterhus, Borgny; Hansen, Åse Kristin Skain; Akslen, Lars A.; Vatten, Lars Johan; Opdahl, Signe; Bofin, Anna M. (Journal article; Peer reviewed, 2017)
      Purpose Proliferation is a hallmark of cancer. Using a combined genomic approach, FGD5 amplification has been identified as a driver of proliferation in Luminal breast cancer. We aimed to describe FGD5 copy number change ...

    • H2G-Net: A multi-resolution refinement approach for segmentation of breast cancer region in gigapixel histopathological images 

      Pedersen, André; Smistad, Erik; Rise, Tor Vikan; Dale, Vibeke Grotnes; Pettersen, Henrik P Sahlin; Nordmo, Tor-Arne Schmidt; Bouget, David Nicolas Jean-Mar; Reinertsen, Ingerid; Valla, Marit (Journal article; Peer reviewed, 2022)
      Over the past decades, histopathological cancer diagnostics has become more complex, and the increasing number of biopsies is a challenge for most pathology laboratories. Thus, development of automatic methods for evaluation ...

    • LearnPathology - An Educational Software 

      Haugli, Linn Ansteensen (Master thesis, 2023)
      Bakgrunn: I diagnostisk patologi er det i dag en pågående overgang fra konvensjonell til digital patologi. Digital patologi har vært i bruk i undervisningen på medisinstudiet ved NTNU siden 2017. Under Covid-19-pandemien, ...

    • LearnPathology: Et digitalt læringsverktøy i histologi og patologi Studentaktiv læring og studentenes brukerbehov 

      Ousdal, Aleksander Havnø (Master thesis, 2023)
      Dette hovedoppgavearbeidet undersøker anvendelsen av studentaktiv læring i histologi og patologi innen medisinstudiet. Formålet er å utforske studentenes oppfatninger av utfordringene knyttet til disse fagene og deres behov ...

    • Long term trends of breast cancer incidence according to proliferation status 

      Klæstad, Elise; Opdahl, Signe; Raj, Sunil Xavier; Valla, Marit; Bofin, Anna M. (Peer reviewed; Journal article, 2022)
      Background Long-term breast cancer incidence trends according to proliferation status are poorly described. We studied time-trends in breast cancer incidence, using mitotic count and Ki-67 as markers of proliferation. ...

    • Molecular subtypes of breast cancer: incidence and prognosis 

      Valla, Marit (Doctoral theses at NTNU;2017:276, Doctoral thesis, 2017)
      Forekomsten av brystkreft har over flere tiår økt i den vestlige verden, og i Norge har det vært en dobling av insidensen siden Kreftregisteret startet sin overvåkning av antall krefttilfeller i Norge i 1952. I Norge har ...

    • Molecular Subtypes of Breast Cancer: Long-term Incidence Trends and Prognostic Differences 

      Valla, Marit; Vatten, Lars Johan; Engstrøm, Monica J; Haugen, Olav Anton; Akslen, Lars A.; Bjørngaard, Johan Håkon; Hagen, Anne Irene; Ytterhus, Borgny; Bofin, Anna M.; Opdahl, Signe (Journal article; Peer reviewed, 2016)
      Background: Secular trends in incidence and prognosis of molecular breast cancer subtypes are poorly described. We studied long-term trends in a population of Norwegian women born 1886–1977. Methods: A total of 52,949 ...

    • MRPS23 amplification and gene expression in breast cancer; association with proliferation and the non-basal subtypes 

      Klæstad, Elise; Opdahl, Signe; Engstrøm, Monica J; Ytterhus, Borgny; Wik, Elisabeth; Bofin, Anna Mary; Valla, Marit (Peer reviewed; Journal article, 2020)
      Purpose MRPS23 is recognized as a driver of proliferation in luminal breast cancer. The aims of the present study were to describe MRPS23 copy number change in breast cancer, and to assess associations between MRPS23 ...

    • PAK1 copy number in breast cancer—Associations with proliferation and molecular subtypes 

      Skjervold, Anette Hansen; Valla, Marit; Ytterhus, Borgny; Bofin, Anna M. (Peer reviewed; Journal article, 2023)
      Introduction P21-activated kinase 1 (PAK1) is known to be overexpressed in several human tumour types, including breast cancer (BC). It is located on chromosome 11 (11q13.5-q14.1) and plays a significant role in proliferation ...

    • Proliferation in molecular subtypes of breast cancer 

      Klæstad, Elise (Doctoral theses at NTNU;2023:30, Doctoral thesis, 2023)
      Breast cancer is a heterogeneous disease. Using immunohistochemistry (IHC) and in situ hybridization (ISH) breast cancers can be divided into molecular subtypes with different prognosis and response to treatment. Increased ...

    • The prognostic value of androgen receptors in breast cancer subtypes 

      Kraby, Maria Ryssdal; Valla, Marit; Opdahl, Signe; Haugen, Olav Anton; Sawicka, Joanna Ewa; Engstrøm, Monica J; Bofin, Anna M. (Journal article; Peer reviewed, 2018)
      Purpose Androgen receptor (AR) expression is frequent in breast cancer and has been associated with good prognosis in several studies. The present study investigates AR-expression in relation to molecular subtypes, ...

    • Visual and digital assessment of Ki-67 in breast cancer tissue - a comparison of methods 

      Skjervold, Anette Hansen; Pettersen, Henrik P Sahlin; Valla, Marit; Opdahl, Signe; Bofin, Anna Mary (Peer reviewed; Journal article, 2022)
      Background In breast cancer (BC) Ki-67 cut-off levels, counting methods and inter- and intraobserver variation are still unresolved. To reduce inter-laboratory differences, it has been proposed that cut-off levels for ...