• A pilot study to determine whether combinations of objectively measured activity parameters can be used to differentiate between mixed states, mania, and bipolar depression. 

      Scott, Janine Linda; Vaaler, Arne; Fasmer, Ole Bernt; Morken, Gunnar; Krane-Gartiser, Karoline (Journal article; Peer reviewed, 2017)
      Background Until recently, actigraphy studies in bipolar disorders focused on sleep rather than daytime activity in mania or depression, and have failed to analyse mixed episodes separately. Furthermore, even those studies ...
    • A pragmatic effectiveness randomized controlled trial of the duration of psychiatric hospitalization in a trans- diagnostic sample of patients with acute mental illness admitted to a ward with either blue-depleted evening lighting or normal lighting conditions 

      Scott, Janine Linda; Langsrud, Knut; Vethe, Daniel; Kjørstad, Kaia; Vestergaard, Cecilie Lund; Faaland, Patrick; Lydersen, Stian; Vaaler, Arne; Morken, Gunnar; Torgersen, Terje; Kallestad, Håvard (Journal article; Peer reviewed, 2019)
      Background There is increasing recognition of the need to stabilize sleep-wake cycles in individuals with major mental disorders. As such, clinicians and researchers advocate the use of interventions targeted at sleep and ...
    • A prospective three-year follow-up study on the clinical significance of anti-neuronal antibodies in acute psychiatric disorders 

      Schou, Morten Brix; Sæther, Sverre Georg; Drange, Ole Kristian; Brenner, Eiliv; Crespi, Joan Vidal; Eikenes, Live; Mykland, Martin Syvertsen; Pintzka, Carl Wolfgang Schøyen; Håberg, Asta; Sand, Trond; Vaaler, Arne; Kondziella, Daniel (Peer reviewed; Journal article, 2019)
      The clinical significance of anti-neuronal antibodies for psychiatric disorders is controversial. We investigated if a positive anti-neuronal antibody status at admission to acute psychiatric inpatient care was associated ...
    • Actigraphy as an objective intra‑individual marker of activity patterns in acute‑phase bipolar disorder: a case series 

      Krane-Gartiser, Karoline; Asheim, Andreas; Fasmer, Ole Bernt; Morken, Gunnar; Vaaler, Arne; Scott, Janine Linda (Journal article; Peer reviewed, 2018)
      Background Actigraphy could be an objective alternative to clinical ratings of motor activity in bipolar disorder (BD), which is of importance now that increased activity and energy are added as cardinal symptoms of ...
    • Acute unstable depressive syndrome (AUDS) is associated more frequently with epilepsy than major depression 

      Vaaler, Arne; Morken, Gunnar; Iversen, Valentina Cabral; Kondziella, Daniel; Linaker, Olav Morten (Journal article; Peer reviewed, 2010)
      Background: Depressive disorders are frequent in epilepsy and associated with reduced seizure control. Almost 50% of interictal depressive disorders have to be classified as atypical depressions according to DSM-4 ...
    • Biomarkers of Systemic and Neuronal Autoimmunity in Acute Psychiatric Disorders 

      Sæther, Sverre Georg (Doctoral theses at NTNU;2018:179, Doctoral thesis, 2018)
      Summary: Introduction and aims: Patients with autoimmune disorders with autoantibodies against systemic and neuronal targets frequently present with neuropsychiatric symptoms. The literature on the prevalence and clinical ...
    • Bipolar disorder bordering neurological conditions: A study of phenotypic and genotypic overlaps 

      Drange, Ole Kristian (Doctoral theses at NTNU;2021:141, Doctoral thesis, 2021)
      Humans have tried to discern – or diagnose – mental disorders for thousands of years. The validity of diagnoses can be assessed in many ways. Construct validity assumes that patients with the same diagnosis should have ...
    • Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders 

      Andlauer, Till F.M.; Guzman-Parra, José; Streit, Fabian; Strohmaier, Jana; González, Maria José; Flores, Susana Gil; Fabeiro, Francisco J. Cabaleiro; Noriega, Francisco del Río; Perez, Fermin Perez; González, Jesus Haro; Diaz, Guillermo Orozco; Diego-Otero, Yolanda de; Moreno-Küstner, Berta; Auburger, Georg; Degenhardt, Franziska; Heilmann-Heimbach, Stefanie; Herms, Stefan; Hoffmann, Per; Frank, Josef; Foo, Jerome C.; Treutlein, Jens; Witt, Stephanie H.; Cichon, Sven; Kogevinas, Manolis; Bøen, Erlend; Dale, Anders M.; Djurovic, Srdjan; Elvsåshagen, Torbjørn; Reinbold, Céline Sonja; Smeland, Olav Bjerkehagen; Agartz, Ingrid; Melle, Ingrid; Ødegaard, Ketil Joachim; Stordal, Eystein; Andreassen, Ole; Rivas, Fabio; Mayoral, Fermín; Müller-Myhsok, Bertram; Forstner, Andreas J.; Nöthen, Markus M.; Rietschel, Marcella; Stahl, Eli A.; Breen, Gerome; McQuillin, Andrew; Ripke, Stephan; Trubetskoy, Vassily; Mattheisen, Manuel; Wang, Yunpeng; Morken, Gunnar; Vaaler, Arne (Peer reviewed; Journal article, 2021)
      Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) ...
    • Challenges in detecting and diagnosing substance use in women in the acute psychiatric department: A naturalistic cohort study 

      Iversen, Valentina Cabral; Guzey, Ismail Cuneyt; Sallaup, Torill Vassli; Vaaler, Arne (Journal article; Peer reviewed, 2016)
      Background: This study examines sex differences in substance use and substance use disorder in the acute psychiatric department, and possible interactions between sex and clinical and social factors associated with this ...
    • Clinical characteristics of patients with bipolar disorder and premorbid traumatic brain injury: a cross-sectional study 

      Drange, Ole Kristian; Vaaler, Arne; Morken, Gunnar; Andreassen, Ole Andreas; Malt, Ulrik Fredrik; Finseth, Per Ivar (Journal article; Peer reviewed, 2018)
      Background About one in ten diagnosed with bipolar disorder (BD) has experienced a premorbid traumatic brain injury (TBI), while not fulfilling the criteria of bipolar and related disorder due to another medical condition ...
    • Clinical differences between immigrants voluntarily and involuntarily admitted to acute psychiatric units: a 3-year prospective study 

      Iversen, Valentina Cabral; Berg, John Erik; Småvik, Rita; Vaaler, Arne (Journal article; Peer reviewed, 2011)
    • Cytokines in agitated and non-agitated patients admitted to an acute psychiatric department: A cross-sectional study 

      Larsen, Jeanette Brun; Stunes, Astrid Kamilla; Vaaler, Arne; Reitan, Solveig Merete Klæbo (Journal article; Peer reviewed, 2019)
      Background:Different psychiatric diagnostic groups have been reported to have cytokine levels deviating from healthy controls. In acute clinical settings however, the specific challenging symptoms and signs are more important ...
    • Cytokines in Relation to Motor Activity in an Acute Psychiatric Population 

      Larsen, Jeanette Brun; Stunes, Astrid Kamilla; Iversen, Valentina Cabral; Vaaler, Arne; Reitan, Solveig Merete Klæbo (Peer reviewed; Journal article, 2019)
      Background: Deviations in motor activity are important clinical features of several psychiatric disorders in an acute state. Immune activity is associated with several psychiatric disorders and may affect motor activity. ...
    • Differences in course of illness between patients with bipolar II disorder with and without epileptiform discharges or other sharp activity on electroencephalograms: a cross-sectional study 

      Drange, Ole Kristian; Sæther, Sverre Georg; Finseth, Per Ivar; Morken, Gunnar; Vaaler, Arne; Arntsen, Vibeke; Henning, Oliver Johannes; Andreassen, Ole Andreas; Elvsåshagen, Torbjørn; Malt, Ulrik Fredrik; Bøen, Erlend (Peer reviewed; Journal article, 2020)
      Background A diagnosis of bipolar II disorder requires that the symptoms cannot be better explained by a medical condition. Epilepsy is in some cases associated with an affective syndrome mimicking an unstable bipolar ...
    • Epilepsy and other seizure disorders in acute psychiatric inpatients 

      Nakken, Erlend Iversen; Grinde, Frithjof; Vaaler, Arne; Drange, Ole Kristian; Brodtkorb, Eylert; Sæther, Sverre Georg (Peer reviewed; Journal article, 2021)
      Background: It is well known that patients with epilepsy have a high rate of psychiatric comorbidity. However, studies exploring epilepsy in psychiatric cohorts are scarce. The aim of this study was to examine the prevalence ...
    • Epitope specificity of anti-synapsin autoantibodies: Differential targeting of synapsin I domains 

      Mertens, Robert; Melchert, Sarah; Gitler, Daniel; Schou, Morten Brix; Sæther, Sverre Georg; Vaaler, Arne; Piepgras, Johannes; Kochova, Elena; Benfenati, Fabio; Ahnert-Hilger, Gudrun; Ruprecht, Klemens; Höltje, Markus (Journal article; Peer reviewed, 2018)
      Objective To identify the specific domains of the presynaptic protein synapsin targeted by recently described autoantibodies to synapsin. Methods Sera of 20 and CSF of two patients with different psychiatric and ...
    • Extracellular vesicles in patients in the acute phase of psychosis and after clinical improvement: an explorative study 

      Tunset, Mette Elise; Haslene-Hox, Hanne; Bossche, Tim Van Den; Vaaler, Arne; Sulheim, Einar; Kondziella, Daniel (Peer reviewed; Journal article, 2020)
      Extracellular vesicles (EVs) are cell-derived structures that transport proteins, lipids and nucleic acids between cells, thereby affecting the phenotype of the recipient cell. As the content of EVs reflects the status of ...
    • Genome-wide association study identifies 30 loci associated with bipolar disorder 

      Stahl, Eli A.; Breen, Gerome; Forstner, Andreas J.; McQuillin, Andrew; Ripke, Stephan; Trubetskoy, Vassily; Mattheisen, Manuel; Wang, Yunpeng; Coleman, Jonathan R.I.; Gaspar, Héléna A.; de Leeuw, Christiaan A.; Steinberg, Stacy; Pavlides, Jennifer M. Whitehead; Trzaskowski, Maciej; Byrne, Enda M.; Pers, Tune H.; Holmans, Peter A.; Richards, Alexander L.; Abbott, Liam; Agerbo, Esben; Akil, Huda; Albani, Diego; Alliey-Rodriguez, Ney; Als, Thomas D.; Anjorin, Adebayo; Antilla, Verneri; Awasthi, Swapnil; Badner, Judith A.; Bækvad-Hansen, Marie; Barchas, Jack D.; Bass, Nicholas; Bauer, Michael; Belliveau, Richard; Bergen, Sarah E.; Pedersen, Carsten Bøcker; Bøen, Erlend; Boks, Marco P.; Boocock, James; Budde, Monika; Bunney, William; Burmeister, Margit; Bybjerg-Grauholm, Jonas; Byerley, William; Casas, Miquel; Cerrato, Felecia; Cervantes, Pablo; Chambert, Kimberly; Charney, Alxander W.; Chen, Danfeng; Churchhouse, Claire; Clarke, Toni-Kim; Coryell, William; Craig, David W.; Cruceanu, Cristiana; Curtis, David; Czerski, Piotr M.; Dale, Anders; de Jong, Simone; Degenhardt, Franziska; Del-Favero, Jurgen; Depaulo, J. Raymond; Djurovic, Srdjan; Dobbyn, Amanda L.; Dumont, Ashley; Elvsåshagen, Torbjørn; Escott-Price, Valentina; Fan, Chun Chieh; Fischer, Sascha B.; Flickinger, Matthew; Foroud, Tatiana M.; Forty, Liz; Frank, Josef; Fraser, Christine; Freimer, Nelson B.; Frisén, Louise; Gade, Katrin; Gage, Diane; Garnham, Julie; Giambartolomei, Claudia; Pedersen, Marianne Giørtz; Goldstein, Jaqueline; Gordon, Scott D.; Gordon-Smith, Katherine; Green, Elaine K.; Green, Melissa J.; Greenwood, Tifany A.; Grove, Jakob; Guan, Weihua; Guzman-Parra, José; Hamshere, Marian L.; Hautzinger, Martin; Heilbronner, Urs; Herms, Stefan; Hipolito, Maria; Hoffmann, Per; Holland, Dominic; Huckins, Laura; Jamain, Stéphane; Johnson, Jessica S.; Juréus, Anders; Kandaswamy, Radhika; Karlsson, Robert; Kennedy, James L.; Kittel-Schneider, Sarah; Knowles, James A.; Kogevinas, Manolis; Koller, Anna C.; Kupka, Ralph; Lavebratt, Catharina; Lawrence, Jacob; Lawson, William B.; Leber, Markus; Lee, Phil H.; Levy, Shawn E.; Li, Jun Z.; Liu, Chunyu; Lucae, Susanne; Maaser, Anna; MacIntyre, Donald J.; Mahon, Pamela B.; Maier, Wolfgang; Martinsson, Lina; McCarroll, Steve; McGuffin, Peter; McInnis, Melvin G.; McKay, James D.; Medeiros, Helena; Medland, Sarah E.; Meng, Fan; Milani, Lili; Montgomery, Grant W.; Morris, Derek W.; Mühleisen, Thomas W.; Mullins, Niamh; Nguyen, Hoang; Nievergelt, Caroline M.; Adolfsson, Annelie Nordin; Nwulia, Evaristus A.; O'Donovan, Claire; Loohuis, Loes M. Olde; Ori, Anil P.S.; Oruc, Lilijana; Ösby, Urban; Perlis, Roy H.; Perry, Amy; Pfennig, Andrea; Potash, James B.; Purcell, Shaun M.; Regeer, Eline J.; Reif, Andreas; Reinbold, Céline S.; Rice, John P.; Rivas, Fabio; Rivera, Margarita; Roussos, Panos; Ruderfer, Douglas M.; Ryu, Euijung; Sánchez-Mora, Cristina; Schatzberg, Alan F.; Scheftner, William A.; Schork, Nicholas J.; Shannon Weickert, Cynthia; Shehktman, Tatyana; Shilling, Paul D.; Sigurdsson, Engilbert; Slaney, Claire; Smeland, Olav Bjerkehagen; Sobell, Janet L.; Søholm Hansen, Christine; Spijker, Anne T.; St Clair, David; Steffens, Michael; Strauss, John S.; Streit, Fabian; Strohmaier, Jana; Szelinger, Szabolcs; Thompson, Robert C.; Thorgeirsson, Thorgeir E; Treutlein, Jens; Vedder, Helmut; Wang, Weiqing; Watson, Stanley J.; Weickert, Thomas W.; Witt, Stephanie H.; Xi, Simon; Xu, Wei; Young, Allan H.; Zandi, Peter; Zhang, Peng; Zöllner, Sebastian; Adolfsson, Rolf; Agartz, Ingrid; Alda, Martin; Backlund, Lena; Baune, Bernhard T.; Bellivier, Frank; Berrettini, Wade H.; Biernacka, Joanna M.; Blackwood, Douglas H.R.; Boehnke, Michael; Børglum, Anders D.; Corvin, Aiden; Craddock, Nicholas; Daly, Mark J.; Dannlowski, Udo; Esko, Tõnu; Etain, Bruno; Frye, Mark; Fullerton, Janice M.; Gershon, Elliot S.; Gill, Michael; Goes, Fernando; Grigoroiu-Serbanescu, Maria; Hauser, Joanna; Hougaard, David M.; Hultman, Christina M.; Jones, Ian; Jones, Lisa A.; Kahn, René S.; Kirov, George; Landén, Mikael; Leboyer, Marion; Lewis, Cathryn M.; Li, Qingqin S.; Lissowska, Jolanta; Martin, Nicholas G.; Mayoral, Fermin; McElroy, Susan L.; McIntosh, Andrew M.; McMahon, Francis J.; Melle, Ingrid; Metspalu, Andres; Mitchell, Philip B.; Morken, Gunnar; Mors, Ole; Mortensen, Preben Bo; Müller-Myhsok, Bertram; Myers, Richard M.; Neale, Benjamin M.; Nimgaonkar, Vishwajit; Nordentoft, Merete; Nöthen, Markus M.; O'Donovan, Michael C; Ødegaard, Ketil Joachim; Owen, Michael J.; Paciga, Sara A.; Pato, Carlos; Pato, Michele T.; Posthuma, Danielle; Ramos-Quiroga, Josep Antoni; Ribasés, Marta; Rietschel, Marcella; Rouleau, Guy A.; Schalling, Martin; Schofield, Peter R.; Schulze, Thomas G.; Serretti, Alessandro; Smoller, Jordan W.; Stefansson, Hreinn; Stefansson, Kari; Stordal, Eystein; Sullivan, Patrick F.; Turecki, Gustavo; Vaaler, Arne; Vieta, Eduard; Vincent, John B.; Werge, Thomas; Nurnberger, John I.; Wray, Naomi R.; Di Florio, Arianna; Edenberg, Howard J.; Cichon, Sven; Ophoff, Roel A.; Scott, Laura J.; Andreassen, Ole Andreas; Kelsoe, John; Sklar, Pamela (Journal article; Peer reviewed, 2019)
      Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with ...
    • Lower circulating neuron-specific enolase concentrations in adults and adolescents with severe mental illness 

      Andreou, Dimitrios; Steen, Nils Eiel; Jørgensen, Kjetil Nordbø; Smelror, Runar Elle; Wedervang-Resell, Kirsten; Nerland, Stener; Westlye, Lars Tjelta; Nærland, Terje; Myhre, Anne Margrethe; Joa, Inge; Reitan, Solveig Merete Klæbo; Vaaler, Arne; Morken, Gunnar; Bøen, Erlend; Elvsåshagen, Torbjørn; Boye, Birgitte; Malt, Ulrik Fredrik; Aukrust, Pål; Skrede, Silje; Kroken, Rune Andreas; Johnsen, Erik; Djurovic, Srdjan; Andreassen, Ole; Ueland, Thor; Agartz, Ingrid (Peer reviewed; Journal article, 2021)
      Background Both neurodegenerative and neurodevelopmental abnormalities have been suggested to be part of the etiopathology of severe mental illness (SMI). Neuron-specific enolase (NSE), mainly located in the neuronal ...
    • Mortality among patients discharged from an acute psychiatric department: A 5-year prospective study 

      Prestmo, Astrid; Høyen, Karina Sagmo; Vaaler, Arne; Torgersen, Terje; Drange, Ole Kristian (Peer reviewed; Journal article, 2020)
      The primary aim of the study was to explore the post discharge standardized mortality ratio of patients from an acute psychiatric department in Norway. The secondary aims were to explore if the standardized mortality ratio ...