• A pilot study to determine whether combinations of objectively measured activity parameters can be used to differentiate between mixed states, mania, and bipolar depression. 

      Scott, Janine Linda; Vaaler, Arne; Fasmer, Ole Bernt; Morken, Gunnar; Krane-Gartiser, Karoline (Journal article; Peer reviewed, 2017)
      Background Until recently, actigraphy studies in bipolar disorders focused on sleep rather than daytime activity in mania or depression, and have failed to analyse mixed episodes separately. Furthermore, even those studies ...
    • A pragmatic effectiveness randomized controlled trial of the duration of psychiatric hospitalization in a trans- diagnostic sample of patients with acute mental illness admitted to a ward with either blue-depleted evening lighting or normal lighting conditions 

      Scott, Janine Linda; Langsrud, Knut; Vethe, Daniel; Kjørstad, Kaia; Vestergaard, Cecilie Lund; Faaland, Patrick; Lydersen, Stian; Vaaler, Arne; Morken, Gunnar; Torgersen, Terje; Kallestad, Håvard (Journal article; Peer reviewed, 2019)
      Background There is increasing recognition of the need to stabilize sleep-wake cycles in individuals with major mental disorders. As such, clinicians and researchers advocate the use of interventions targeted at sleep and ...
    • Actigraphy as an objective intra‑individual marker of activity patterns in acute‑phase bipolar disorder: a case series 

      Krane-Gartiser, Karoline; Asheim, Andreas; Fasmer, Ole Bernt; Morken, Gunnar; Vaaler, Arne; Scott, Janine Linda (Journal article; Peer reviewed, 2018)
      Background Actigraphy could be an objective alternative to clinical ratings of motor activity in bipolar disorder (BD), which is of importance now that increased activity and energy are added as cardinal symptoms of ...
    • Acute unstable depressive syndrome (AUDS) is associated more frequently with epilepsy than major depression 

      Vaaler, Arne; Morken, Gunnar; Iversen, Valentina Cabral; Kondziella, Daniel; Linaker, Olav Morten (Journal article; Peer reviewed, 2010)
      Background: Depressive disorders are frequent in epilepsy and associated with reduced seizure control. Almost 50% of interictal depressive disorders have to be classified as atypical depressions according to DSM-4 ...
    • Biomarkers of Systemic and Neuronal Autoimmunity in Acute Psychiatric Disorders 

      Sæther, Sverre Georg (Doctoral theses at NTNU;2018:179, Doctoral thesis, 2018)
      Summary: Introduction and aims: Patients with autoimmune disorders with autoantibodies against systemic and neuronal targets frequently present with neuropsychiatric symptoms. The literature on the prevalence and clinical ...
    • Challenges in detecting and diagnosing substance use in women in the acute psychiatric department: A naturalistic cohort study 

      Iversen, Valentina Cabral; Guzey, Ismail Cuneyt; Sallaup, Torill Vassli; Vaaler, Arne (Journal article; Peer reviewed, 2016)
      Background: This study examines sex differences in substance use and substance use disorder in the acute psychiatric department, and possible interactions between sex and clinical and social factors associated with this ...
    • Clinical characteristics of patients with bipolar disorder and premorbid traumatic brain injury: a cross-sectional study 

      Drange, Ole Kristian; Vaaler, Arne; Morken, Gunnar; Andreassen, Ole Andreas; Malt, Ulrik Fredrik; Finseth, Per Ivar (Journal article; Peer reviewed, 2018)
      Background About one in ten diagnosed with bipolar disorder (BD) has experienced a premorbid traumatic brain injury (TBI), while not fulfilling the criteria of bipolar and related disorder due to another medical condition ...
    • Clinical differences between immigrants voluntarily and involuntarily admitted to acute psychiatric units: a 3-year prospective study 

      Iversen, Valentina Cabral; Berg, John Erik; Småvik, Rita; Vaaler, Arne (Journal article; Peer reviewed, 2011)
    • Cytokines in agitated and non-agitated patients admitted to an acute psychiatric department: A cross-sectional study 

      Larsen, Jeanette Brun; Stunes, Astrid Kamilla; Vaaler, Arne; Reitan, Solveig Merete Klæbo (Journal article; Peer reviewed, 2019)
      Background:Different psychiatric diagnostic groups have been reported to have cytokine levels deviating from healthy controls. In acute clinical settings however, the specific challenging symptoms and signs are more important ...
    • Epitope specificity of anti-synapsin autoantibodies: Differential targeting of synapsin I domains 

      Mertens, Robert; Melchert, Sarah; Gitler, Daniel; Schou, Morten Brix; Sæther, Sverre Georg; Vaaler, Arne; Piepgras, Johannes; Kochova, Elena; Benfenati, Fabio; Ahnert-Hilger, Gudrun; Ruprecht, Klemens; Höltje, Markus (Journal article; Peer reviewed, 2018)
      Objective To identify the specific domains of the presynaptic protein synapsin targeted by recently described autoantibodies to synapsin. Methods Sera of 20 and CSF of two patients with different psychiatric and ...
    • Genome-wide association study identifies 30 loci associated with bipolar disorder 

      Stahl, Eli A.; Breen, Gerome; Forstner, Andreas J.; McQuillin, Andrew; Ripke, Stephan; Trubetskoy, Vassily; Mattheisen, Manuel; Wang, Yunpeng; Coleman, Jonathan R.I.; Gaspar, Héléna A.; de Leeuw, Christiaan A.; Steinberg, Stacy; Pavlides, Jennifer M. Whitehead; Trzaskowski, Maciej; Byrne, Enda M.; Pers, Tune H.; Holmans, Peter A.; Richards, Alexander L.; Abbott, Liam; Agerbo, Esben; Akil, Huda; Albani, Diego; Alliey-Rodriguez, Ney; Als, Thomas D.; Anjorin, Adebayo; Antilla, Verneri; Awasthi, Swapnil; Badner, Judith A.; Bækvad-Hansen, Marie; Barchas, Jack D.; Bass, Nicholas; Bauer, Michael; Belliveau, Richard; Bergen, Sarah E.; Pedersen, Carsten Bøcker; Bøen, Erlend; Boks, Marco P.; Boocock, James; Budde, Monika; Bunney, William; Burmeister, Margit; Bybjerg-Grauholm, Jonas; Byerley, William; Casas, Miquel; Cerrato, Felecia; Cervantes, Pablo; Chambert, Kimberly; Charney, Alxander W.; Chen, Danfeng; Churchhouse, Claire; Clarke, Toni-Kim; Coryell, William; Craig, David W.; Cruceanu, Cristiana; Curtis, David; Czerski, Piotr M.; Dale, Anders; de Jong, Simone; Degenhardt, Franziska; Del-Favero, Jurgen; Depaulo, J. Raymond; Djurovic, Srdjan; Dobbyn, Amanda L.; Dumont, Ashley; Elvsåshagen, Torbjørn; Escott-Price, Valentina; Fan, Chun Chieh; Fischer, Sascha B.; Flickinger, Matthew; Foroud, Tatiana M.; Forty, Liz; Frank, Josef; Fraser, Christine; Freimer, Nelson B.; Frisén, Louise; Gade, Katrin; Gage, Diane; Garnham, Julie; Giambartolomei, Claudia; Pedersen, Marianne Giørtz; Goldstein, Jaqueline; Gordon, Scott D.; Gordon-Smith, Katherine; Green, Elaine K.; Green, Melissa J.; Greenwood, Tifany A.; Grove, Jakob; Guan, Weihua; Guzman-Parra, José; Hamshere, Marian L.; Hautzinger, Martin; Heilbronner, Urs; Herms, Stefan; Hipolito, Maria; Hoffmann, Per; Holland, Dominic; Huckins, Laura; Jamain, Stéphane; Johnson, Jessica S.; Juréus, Anders; Kandaswamy, Radhika; Karlsson, Robert; Kennedy, James L.; Kittel-Schneider, Sarah; Knowles, James A.; Kogevinas, Manolis; Koller, Anna C.; Kupka, Ralph; Lavebratt, Catharina; Lawrence, Jacob; Lawson, William B.; Leber, Markus; Lee, Phil H.; Levy, Shawn E.; Li, Jun Z.; Liu, Chunyu; Lucae, Susanne; Maaser, Anna; MacIntyre, Donald J.; Mahon, Pamela B.; Maier, Wolfgang; Martinsson, Lina; McCarroll, Steve; McGuffin, Peter; McInnis, Melvin G.; McKay, James D.; Medeiros, Helena; Medland, Sarah E.; Meng, Fan; Milani, Lili; Montgomery, Grant W.; Morris, Derek W.; Mühleisen, Thomas W.; Mullins, Niamh; Nguyen, Hoang; Nievergelt, Caroline M.; Adolfsson, Annelie Nordin; Nwulia, Evaristus A.; O'Donovan, Claire; Loohuis, Loes M. Olde; Ori, Anil P.S.; Oruc, Lilijana; Ösby, Urban; Perlis, Roy H.; Perry, Amy; Pfennig, Andrea; Potash, James B.; Purcell, Shaun M.; Regeer, Eline J.; Reif, Andreas; Reinbold, Céline S.; Rice, John P.; Rivas, Fabio; Rivera, Margarita; Roussos, Panos; Ruderfer, Douglas M.; Ryu, Euijung; Sánchez-Mora, Cristina; Schatzberg, Alan F.; Scheftner, William A.; Schork, Nicholas J.; Shannon Weickert, Cynthia; Shehktman, Tatyana; Shilling, Paul D.; Sigurdsson, Engilbert; Slaney, Claire; Smeland, Olav Bjerkehagen; Sobell, Janet L.; Søholm Hansen, Christine; Spijker, Anne T.; St Clair, David; Steffens, Michael; Strauss, John S.; Streit, Fabian; Strohmaier, Jana; Szelinger, Szabolcs; Thompson, Robert C.; Thorgeirsson, Thorgeir E; Treutlein, Jens; Vedder, Helmut; Wang, Weiqing; Watson, Stanley J.; Weickert, Thomas W.; Witt, Stephanie H.; Xi, Simon; Xu, Wei; Young, Allan H.; Zandi, Peter; Zhang, Peng; Zöllner, Sebastian; Adolfsson, Rolf; Agartz, Ingrid; Alda, Martin; Backlund, Lena; Baune, Bernhard T.; Bellivier, Frank; Berrettini, Wade H.; Biernacka, Joanna M.; Blackwood, Douglas H.R.; Boehnke, Michael; Børglum, Anders D.; Corvin, Aiden; Craddock, Nicholas; Daly, Mark J.; Dannlowski, Udo; Esko, Tõnu; Etain, Bruno; Frye, Mark; Fullerton, Janice M.; Gershon, Elliot S.; Gill, Michael; Goes, Fernando; Grigoroiu-Serbanescu, Maria; Hauser, Joanna; Hougaard, David M.; Hultman, Christina M.; Jones, Ian; Jones, Lisa A.; Kahn, René S.; Kirov, George; Landén, Mikael; Leboyer, Marion; Lewis, Cathryn M.; Li, Qingqin S.; Lissowska, Jolanta; Martin, Nicholas G.; Mayoral, Fermin; McElroy, Susan L.; McIntosh, Andrew M.; McMahon, Francis J.; Melle, Ingrid; Metspalu, Andres; Mitchell, Philip B.; Morken, Gunnar; Mors, Ole; Mortensen, Preben Bo; Müller-Myhsok, Bertram; Myers, Richard M.; Neale, Benjamin M.; Nimgaonkar, Vishwajit; Nordentoft, Merete; Nöthen, Markus M.; O'Donovan, Michael C; Ødegaard, Ketil Joachim; Owen, Michael J.; Paciga, Sara A.; Pato, Carlos; Pato, Michele T.; Posthuma, Danielle; Ramos-Quiroga, Josep Antoni; Ribasés, Marta; Rietschel, Marcella; Rouleau, Guy A.; Schalling, Martin; Schofield, Peter R.; Schulze, Thomas G.; Serretti, Alessandro; Smoller, Jordan W.; Stefansson, Hreinn; Stefansson, Kari; Stordal, Eystein; Sullivan, Patrick F.; Turecki, Gustavo; Vaaler, Arne; Vieta, Eduard; Vincent, John B.; Werge, Thomas; Nurnberger, John I.; Wray, Naomi R.; Di Florio, Arianna; Edenberg, Howard J.; Cichon, Sven; Ophoff, Roel A.; Scott, Laura J.; Andreassen, Ole Andreas; Kelsoe, John; Sklar, Pamela (Journal article; Peer reviewed, 2019)
      Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with ...
    • Motor activity patterns in acute schizophrenia and other psychotic disorders can be differentiated from bipolar mania and unipolar depression 

      Krane-Gartiser, Karoline; Henriksen, Tone Elise Gjøtterud; Morken, Gunnar; Vaaler, Arne; Fasmer, Ole Bernt (Journal article; Peer reviewed, 2018)
      The purpose of this study was to compare 24-h motor activity patterns between and within three groups of acutely admitted inpatients with schizophrenia and psychotic disorders (n = 28), bipolar mania (n = 18) and motor-retarded ...
    • Quantitative EEG findings in patients with acute, brief depression combined with other fluctuating psychiatric symptoms: a controlled study from an acute psychiatric department 

      Bjørk, Marte Helene; Sand, Trond; Bråthen, Geir; Linaker, Olav Morten; Morken, Gunnar; Nilsen, Brigt; Vaaler, Arne (Journal article; Peer reviewed, 2008)
      Background: Patients with brief depressive episodes and concurrent rapidly fluctuating psychiatric symptoms do not fit current diagnostic criteria and they can be difficult to diagnose and treat in an acute psychiatric ...
    • Short-term prediction of threatening and violent behaviour in an Acute Psychiatric Intensive Care Unit based on patient and environment characteristics 

      Vaaler, Arne; Iversen, Valentina Cabral; Morken, Gunnar; Fløvig, John Chr.; Palmstierna, Tom; Linaker, Olav Morten (Journal article; Peer reviewed, 2011)
      Background: The aims of the present study were to investigate clinically relevant patient and environment-related predictive factors for threats and violent incidents the first three days in a PICU population based on ...
    • Subtle Phenotype Differences in Psychiatric Patients With and Without Serum Immunoglobulin G Antibodies to Synapsin 

      Sæther, Sverre Georg; Vaaler, Arne; Evjenth, Anita; Aune, Therese Lie; Höltje, Markus; Ruprecht, Klemens; Schou, Morten Brix (Journal article; Peer reviewed, 2019)
      The discovery that antibodies targeting neuronal antigens can induce severe psychiatric symptoms has been a significant progress in the understanding of psychiatric disorders. Antibodies targeting synapsin I in serum and ...
    • Symptoms of epilepsy and organic brain dysfunctions in patients with acute, brief depression combined with other fluctuating psychiatric symptoms: a controlled study from an acute psychiatric department 

      Vaaler, Arne; Morken, Gunnar; Linaker, Olav Morten; Sand, Trond; Kvistad, Kjell Arne; Bråthen, Geir (Journal article; Peer reviewed, 2009)
      Background: In psychiatric acute departments some patients present with brief depressive periods accompanied with fluctuating arrays of other psychiatric symptoms like psychosis, panic or mania. For the purpose of the ...
    • The Predictive Properties of Violence Risk Instruments May Increase by Adding Items Assessing Sleep. 

      Langsrud, Knut; Vaaler, Arne; Morken, Gunnar; Kallestad, Håvard; Almvik, Roger; Palmstierna, Tom Krisman Kule; Guzey, Ismail Cuneyt (Journal article; Peer reviewed, 2019)
      Background: The psychometric instruments developed for short-term prediction of violence in psychiatric inpatients do not include variables assessing sleep. Disturbances in sleep may precede aggression in this setting. We ...
    • The significance of anti-neuronal antibodies for acute psychiatric disorders: a retrospective case-controlled study 

      Schou, Morten Brix; Sæther, Sverre Georg; Drange, Ole Kristian; Krane-Gartiser, Karoline; Reitan, Solveig Merete Klæbo; Vaaler, Arne; Kondziella, Daniel (Journal article; Peer reviewed, 2018)
      Background The clinical significance of anti-neuronal antibodies in patients with psychiatric disorders, but without encephalitis, remains unknown. In patients admitted to acute psychiatric inpatient care we aimed to ...
    • Variability of activity patterns across mood disorders and time of day 

      Krane-Gartiser, Karoline; Vaaler, Arne; Fasmer, Ole Bernt; Sørensen, Kjetil; Morken, Gunnar; Scott, Janine Linda (Journal article; Peer reviewed, 2017)
      Background: Few actigraphy studies in mood disorders have simultaneously included unipolar (UP) and bipolar (BD) depression or BD mixed states as a separate subgroup from mania. This study compared objectively measured ...