Browsing NTNU Open by Author "Urbanics, Rudolf"
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Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes
Wibroe, Peter Popp; Anselmo, Aaron C; Nilsson, Per; Sarode, Apoorva; Gupta, Vivek; Urbanics, Rudolf; Szebeni, Janos; Hunter, Alan Christy; Mitragotri, Samir; Mollnes, Tom Eirik; Moghimi, Seyed Moein (Journal article, 2017)Intravenously injected nanopharmaceuticals, including PEGylated nanoparticles, induce adverse cardiopulmonary reactions in sensitive human subjects, and these reactions are highly reproducible in pigs. Although the underlying ... -
A porcine model of hemodialyzer reactions: roles of complement activation and rinsing back of extracorporeal blood
Pethő, Ákos; Piecha, Dorothea; Mészáros, Tamás; Urbanics, Rudolf; Moore, Christoph; Canaud, Bernard; Rosivall, László; Mollnes, Tom Eirik; Steppan, Sonja; Szénási, Gábor; Szebeni, János; Dézsi, László (Journal article; Peer reviewed, 2021)Hemodialysis reactions (HDRs) resemble complement-activation-related pseudoallergy (CARPA) to certain i.v. drugs, for which pigs provide a sensitive model. On this basis, to better understand the mechanism of human HDRs, ... -
Pseudo-anaphylaxis to polyethylene glycol (PEG)-coated liposomes: Roles of anti-PEG IgM and complement activation in a porcine model of human infusion reactions
Kozma, Gergely Tibor; Mészáros, Támas; Vashegyi, Ildikó; Fülöp, Tamás Gábor; Örfi, Erik; Dézsi, László; Rosivall, László; Bavli, Yaelle; Urbanics, Rudolf; Mollnes, Tom Eirik; Barenholz, Yechezkel; Szebeni, János (Journal article; Peer reviewed, 2019)Polyethylene glycol (PEG)-coated nanopharmaceuticals can cause mild to severe hypersensitivity reactions (HSRs), which can occasionally be life threatening or even lethal. The phenomenon represents an unsolved immune barrier ...